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Cyclosporine a Nephrotoxicity

  • Chapter
International Yearbook of Nephrology 1989

Part of the book series: International Yearbooks of Nephrology ((IYNE,volume 1))

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Abstract

Despite the many studies performed both in humans and in experimental animals during the decade which has elapsed since the introduction of Cyclosporine A (CyA) into clinical practice, the mechanisms by which CyA damages the kidneys is still poorly defined. The main problem faced in the past years in studying CyA nephrotoxicity is related to the almost exclusive clinical use of CyA in renal transplant recipients, i.e. in patients who initially (soon after transplantation) exhibit, in the transplanted kidney, the consequences of ischemic injury, and then undergo acute and/or chronic renal allograft rejection; these conditions make CyA-induced renal impairment difficult to isolate. Only in recent years has clinical experience been gained in humans with previously healthy native kidneys, i.e. in heart, liver or bone marrow transplant recipients or in patients treated with CyA for extrarenal diseases (1).

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Authors and Affiliations

  1. Department of Nephrology, Second Medical School, University of Naples, Naples, Italy

    V. E. Andreucci & G. Fuiano

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  1. V. E. Andreucci
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  2. G. Fuiano
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Editors and Affiliations

  1. University of Naples, Naples, Italy

    Vittorio E. Andreucci

  2. University of California, Los Angeles, School of Medicine, California, USA

    Leon G. Fine

  3. Nihon University, Tokyo, Japan

    Michinobu Hatano

  4. Karolinska Hospital, Stockholm, Sweden

    Carl M. Kjellstrand

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Andreucci, V.E., Fuiano, G. (1989). Cyclosporine a Nephrotoxicity. In: Andreucci, V.E., Fine, L.G., Hatano, M., Kjellstrand, C.M. (eds) International Yearbook of Nephrology 1989. International Yearbooks of Nephrology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1673-2_9

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