Cyclosporin in the Therapy of Idiopathic Nephrotic Syndrome in Children

  • P. Niaudet
  • M. Broyer
Part of the International Yearbooks of Nephrology book series (IYNE, volume 1)


Idiopathic nephrotic syndrome, which is the most frequent glomerular disease in children, is defined by the combination of nephrotic syndrome and minimal change glomerular disease, with foot process fusion on electron microscopy. No immunoglobulin or complement fraction deposits are seen on immunofluorescent examination. However, in some cases, diffuse mesangial proliferation or focal and segmental glomerulosclerosis may be seen on light microscopy. In addition, immunofluorescent examination sometimes reveals mesangial immunoglobulin deposits found either in isolation or in association with C1q and/or C3 deposits. The most frequently found immunoglobulin is IgM, leading some authors to consider IgM nephropathy as a disease entity (1). IgA deposits have also been found in some patients (2, 3) as well as granular C3 deposits.


Nephrotic Syndrome Idiopathic Nephrotic Syndrome Minimal Change Disease Minimal Change Nephrotic Syndrome Cyclosporin Treatment 
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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • P. Niaudet
    • 1
  • M. Broyer
    • 1
  1. 1.Service de Nephrologie Pédiatrique and INSERM U 192Hôpital Necker-Enfants MaladesParisFrance

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