Diagnostic and Prognostic Implications of Renal Hypertrophy

  • Aaron Knecht
  • Leon G. Fine
Part of the International Yearbooks of Nephrology book series (IYNE, volume 1)


Knowledge of cell growth control has increased with great rapidity within the last decade due to the discovery and purification of specific growth factors, the identification of genes which are expressed in a cell-cycle-dependent fashion and an improved understanding of the roles of various oncogenes in control of growth in non-transformed cells. Only recently has the understanding of renal growth control started to advance apace with these discoveries, but the clinical approach to predicting adaptive growth responses or their manipulation is in its infancy. This review attempts to summarize current knowledge of mechanisms of renal hypertrophy and regeneration and to apply the emerging principles to human renal disease. The picture that emerges indicates that, whereas growth in the size of nephrons provides an obvious advantage in prolonging the function of the diseased kidney, in certain cases it may be the harbinger of progressive injury and its control may have important prognostic implications.


Total Parenteral Nutrition Renal Mass Kidney Donor Renal Plasma Flow Solitary Kidney 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Aaron Knecht
    • 1
  • Leon G. Fine
    • 1
  1. 1.Division of Nephrology, Department of MedicineUCLA, School of MedicineLos AngelesUSA

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