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Structural Comparisons of Streptococcus Pneumoniae Specific Polysaccharides of Group 9 (9N, 9V, 9L, 9A) Related to the Choice of Vaccine Components

  • James C. Richards
  • Malcolm B. Perry
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 228)

Abstract

Within the group 9 Streptococcus pneumoniae, four serologically cross reacting types are recognized (9A, 9L, 9N and 9V) which together are responsible for 3–4% of pneumococcal disease in North America1. Microchemical methods of glycose analysis, gas-liquid chromatography-mass spectrometry and 13C and 1H n.m.r. has permitted the complete structural elucidation of the capsular polysaccharides of the four group 9 serotypes2–6. The capsular antigens were found to be polymers of a repeating pentasaccharide unit sharing several similarities but differing in certain component glycoses and the presence of O-acetyl groups (Table).

Keywords

Streptococcus Pneumoniae Pneumococcal Disease Capsular Polysaccharide Vaccine Component Minimum Energy Conformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • James C. Richards
    • 1
  • Malcolm B. Perry
    • 1
  1. 1.Division of Biological SciencesNational Research Council of CanadaOttawaCanada

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