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Neuronal Fibrillar Cytoskeleton and Endomembrane System Organization in Alzheimer’s Disease

  • Mark Ellisman
  • Rama Ranganathan
  • Thomas Deerinck
  • Stephen Young
  • Robert Terry
  • Suzanne Mirra
Part of the Advances in Behavioral Biology book series (ABBI, volume 34)

Abstract

We examined the structural organization of cytoskeletal components and membrane systems in neurons of well preserved biopsy material from Alzheimer’s disease (AD). Information was obtained from thin sectioned material using conventional electron microscopy and from thick sections with the high voltage electron microscope. Stereo viewing and computer assisted serial reconstruction techniques were employed to visualize three-dimensional relationships among cytoplasmic components of cortical neurons.

We observed several interesting ultrastructural features in AD neurons. These include associations of paired helical filaments (PHF) with the membranes of the nuclear envelope and with ribosomes, differences between the distribution of the Golgi apparatus in neurons containing paired helical filament bundles as compared to neurons without these filaments, and abnormalities in the microtubules of neuronal processes in the vicinity of neuritic plaques.

Keywords

Golgi Apparatus Nuclear Envelope Neuritic Plaque Stereo Pair Open Arrow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Mark Ellisman
    • 1
  • Rama Ranganathan
    • 1
  • Thomas Deerinck
    • 1
  • Stephen Young
    • 1
  • Robert Terry
    • 2
  • Suzanne Mirra
    • 2
  1. 1.Laboratory for Neurocytology M008, Department of NeurosciencesUCSDLa JollaUSA
  2. 2.Veterans Administration Medical Center and Emory University School of MedicineAtlantaUSA

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