Abstract
In their excellent book Free Radicals in Biology and Medicine, Halliwell and Gutteridge [5] give a clear exposition of the basic chemistry of free radicals and convince the reader that these intermediates can play a major role in the pathophysiology of tissue injury in many organs and many disease processes. In the field of toxicology, agents such as paraquat, carbon tetrachloride, adriamycin, and alloxan, together with ionizing radiation and a whole range of chemical carcinogens (including those in cigarette smoke), have been shown to exert their deleterious effects through the production of free radicals. Free radicals have been shown to play a major role in the natural history of aging, inflammatory diseases such as rheumatoid arthritis, and various autoimmune conditions.
Any expanding field attracts the charlatans, such as those who make money out of proposing that consuming radical scavengers will make you live for ever or that taking tablets containing superoxide dismutase will enhance your health and sex life. In evaluating these and other less-obviously silly claims, it is useful to understand the basic chemistry of radical reactions.
Halliwell and Gutteridge [1]
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© 1989 Kluwer Academic Publishers, Boston/Dordrecht/London
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Hearse, D.J. (1989). Free Radicals and Myocardial Injury during Ischemia and Reperfusion: A Short-Lived Phenomenon?. In: Rosen, M.R., Palti, Y. (eds) Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction. Developments in Cardiovascular Medicine, vol 94. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1649-7_8
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DOI: https://doi.org/10.1007/978-1-4613-1649-7_8
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