Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage

  • Roberto Ferrari
  • Claudio Ceconi
  • Salvatore Curello
  • Evasio Pasini
  • Odoardo Visioli
Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 5)

Summary

Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10-7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionic acid did not modify myocardial damage.

Key words

propionyl-L-carnitine myocardial-protection post-ischaemic reperfusion oxidative damage 

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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Roberto Ferrari
    • 1
  • Claudio Ceconi
    • 1
  • Salvatore Curello
    • 1
  • Evasio Pasini
    • 1
  • Odoardo Visioli
    • 1
  1. 1.Cattedra di CardiologiaUniversità di BresciaBresciaItaly

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