Thrombolytic Agents: Biologic Properties and Issues Regarding Products Derived by Recombinant DNA Technology
Fibrin deposition plays a role not only in hemostasis, but also in the inflammatory response, defense mechanisms against bacterial invasion, and wound healing. For this mechanism that is perpetually ready to spring into action, the body pays the price of potential accumulation of fibrin microdeposits which constitute a hazard: thrombosis. Counterbalancing this potential danger is the fibrinolytic system which destroys fibrin deposits. In this respect, fibrin deposition may be considered a fundamental mechanism of injured tissue repair and fibrinolysis (thrombolysis) its physiologic antithesis.
KeywordsThrombolytic Therapy Tissue Plasminogen Activator Thrombolytic Agent Fibrin Deposition Chronic Venous Insufficiency
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