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Oncogenes pp 177-195 | Cite as

Transforming growth factors-α and -β and their potential roles in neoplastic transformation

  • Rik Derynck
Part of the Cancer Treatment and Research book series (CTAR, volume 47)

Abstract

Two types of growth factors have been termed transforming growth factors (TGFs) because they were discovered for their ability to elicit cellular transformation when added to an immortalized nonneoplastic cell line. One of these, TGF-α, is structurally related to epidermal growth factor (EGF) and competes for binding to the same receptor, while the other one, TGF-β, is a structurally unrelated protein with distinct receptors.

Keywords

Transform Growth Factor Soft Agar Epidermal Growth Factor Binding Transform Growth Factor Type Normal Inhibitory Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Kluwer Academic Publishers 1989

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  • Rik Derynck

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