Oncogenes pp 3-24 | Cite as

Oncogenes and proto-oncogenes: General concepts

  • Chi V. Dang
Part of the Cancer Treatment and Research book series (CTAR, volume 47)

Abstract

Theoretically, the cancerous phenotype of cells can result from epigenetic or biochemical regulatory changes without alteration of the genotype. Although epigenetic changes may contribute to neoplasia, overwhelming evidence supports the concept that neoplasia results from heritable changes allowing unrestrained growth of cells that are associated with altered expression of certain ‘cancer genes,’ or oncogenes [1,2]. The normal cellular counterparts that probably play some role in normal cell proliferation and differentiation are called proto-oncogenes. Genetic alterations (such as proviral insertional mutations, chromosomal translocation, gene amplification, or point mutations) can activate cellular oncogenes that in turn contribute to neoplasia.

Keywords

Lymphoma Leukemia Leucine Osteosarcoma Neuroblastoma 

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© Kluwer Academic Publishers 1989

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  • Chi V. Dang

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