Abstract
Spontaneous thrombosis of a coronary artery produces regional myocardial ischemia and ultimately an acute myocardial infarction. Recently, thrombolytic agents including streptokinase, urokinase, and tissue plasminogen activator (t-PA) have been used to dissolve the intracoronary thrombus within the early hours of an acute myocardial infarction. More recently percutaneous transluminal coronary angioplasty (PTCA) has also been utilized to reverse an acute coronary occlusion. Both of these procedures result in reperfusion of myocardium at risk for infarction. However, there is controversy as to whether reperfusion, while terminating ischemia, may actually cause a new form of damage to the region of myocardium at risk.
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Zweier, J.L., Flaherty, J.T. (1989). The Role of Free Radicals in the Pathogenesis of Postischemic Reperfusion Injury. In: Rapaport, E. (eds) Early Interventions in Acute Myocardial Infarction. Developments in Cardiovascular Medicine, vol 97. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1597-1_3
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DOI: https://doi.org/10.1007/978-1-4613-1597-1_3
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