Surgical Adjuvant Therapy of Non-Small-Cell Lung Cancer

  • E. Carmack Holmes
Part of the Cancer Treatment and Research book series (CTAR, volume 45)


Lung cancer is the leading cancer killer in the United States. One hundred forty thousand patients will develop lung cancer annually, and half of these patients will have disease confined to the thorax without clinical evidence of dissemination (figure 14.1). About 20% will have stage I disease, 30% will have more advanced local disease, some of whom can be resected surgically with a low expectation of cure, and others with tumor localized to the thorax will be technically unresectable. Surgery alone can cure most patients with T1N0 lesions, and about 60% of the patients with T2N0 and T1N1 tumors can be cured by surgical resection. Surgical treatment alone cures about half the patients with T2N1 squamous disease, and only 25% of the patients with T2N1 adenocarcinoma. A subset of patients with T3N2 disease can expect a favorable survival following surgical resection, but most patients in this category have technically unresectable disease (table 14.1) [1].


Local Recurrence Preoperative Chemotherapy Vinca Alkaloid Preoperative Therapy Systemic Recurrence 
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© Kluwer Academic Publishers, Boston 1989

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  • E. Carmack Holmes

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