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Enhancement of Mammary Tumorigenesis by Dietary Fat: An Endocrine and/or Calorie Mechanism?

  • C. Welsch
Chapter
Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 6)

Abstract

A number of mechanisms have been proposed to explain the enhancement of experimental animal mammary gland tumorigenesis by hyperalimentation of fat, e.g., modification of prostaglandin biosynthesis and immune system activity, generation of lipid peroxy radicals, changing membrane fluidity and an alteration in intercellular communication. In addition, it has been proposed that dietary fat may influence this tumorigenic process by increasing mammotropic hormone secretion or hormone responsiveness or may act via an increasement of caloric consumption. In this communication, the evidence is reviewed that the dietary fat — mammary tumorigenesis relationship is a function of alteration in: a) mammotropic hormone secretion; b) mammotropic hormone responsiveness and/or c) caloric consumption. In summary, the experimental studies do not appear to support a dietary fat-mammotropic hormone secretion relationship. Evidence is presented that dietary fat may affect mammotropic hormone responsiveness. Data derived from numerous studies support the hypothesis that dietary fat can modify mammary tumorigenesis by a process (or processes) independent of caloric consumption. That dietary fat may influence this tumorigenic process by a mechanism that is caloric responsive is, however, a distinct posibility.

Keywords

Mammary Tumor Caloric Consumption Mammary Tumorigenesis Hormone Responsiveness Tumorigenic Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Tannenbaum, A. Cancer Res. 2: 468–475, 1942.Google Scholar
  2. 2.
    Tannenbaum, A. Cancer Res., 5:616–625, 1945.Google Scholar
  3. 3.
    Szepsenwol, J. Proc. Soc. Exp. Biol. Med. 96: 332–335, 1957.PubMedGoogle Scholar
  4. 4.
    Bennett, A.S. Int. J. Cancer 34: 529–532, 1984PubMedCrossRefGoogle Scholar
  5. 5.
    Silverstone, H. and Tannenbaum, A. Cancer Res., 10: 448–453, 1950.PubMedGoogle Scholar
  6. 6.
    Waxler, S.H., Brecher, G. and Beal, S.L. Proc. Soc. Exp. Biol. Med. 162:365–368, 1979.PubMedGoogle Scholar
  7. 7.
    Gridley, D.S., Kettering, J.D., Slater, J.M. and Nutter, R.L. Cancer Letters 19:133–146, 1983.PubMedCrossRefGoogle Scholar
  8. 8.
    Tinsley, I.J., Schmitz, J.A. and Pierce, D.A. Cancer Res., 11:1460–1465, 1981.Google Scholar
  9. 9.
    Szepsenwol, J. Proc. Soc. Exp. Biol. Med. 112:1073–1076, 1963.PubMedGoogle Scholar
  10. 10.
    Szepsenwol, J. Proc. Soc. Exp. Biol. Med. 116:1136–1139, 1964.PubMedGoogle Scholar
  11. 11.
    Lane, H.W., Butel, J.S., Howard, C, Shepherd, F., Halligan, R. and Medina, D. Carcinogenesis 6: 403–407, 1985.PubMedCrossRefGoogle Scholar
  12. 12.
    Hillyard, L.A. and Abraham, S. Cancer Res. 39: 4430–4437, 1979.PubMedGoogle Scholar
  13. 13.
    Giovarelli, M., Podula, E., Ugazio, G., Forni, G. and Cavallo, G. Cancer Res., 40: 3745–3749, 1980.PubMedGoogle Scholar
  14. 14.
    Abraham, S. and Hillyard, L.A. J. Natl. Cancer Inst., 71: 601–605, 1983.PubMedGoogle Scholar
  15. 15.
    Abraham, S., Faulkin, L.J., Hillyard, L.A. and Mitchell, D.J. J. Natl. Cancer Inst., 72: 1421–1429, 1984.Google Scholar
  16. 16.
    Rao, G.A. and Abraham, S. J. Natl. Cancer Inst. 56: 431–432, 1976.PubMedGoogle Scholar
  17. 17.
    Hopkins, G.J. and West, C.E. J. Natl. Cancer Inst. 58: 753–756, 1977.PubMedGoogle Scholar
  18. 18.
    Benson, J., Luv, M. and Grand, C.G. Cancer Res. 16: 135–137, 1956.PubMedGoogle Scholar
  19. 19.
    Davis, R.K., Stevenson, G.T. and Busch, K.A. Cancer Res. 16: 194–197, 1956.PubMedGoogle Scholar
  20. 20.
    Dunning, W.F., Curtiss, M.R. and Maun, M.E. Cancer Res. 9: 354–361, 1949.PubMedGoogle Scholar
  21. 21.
    Gammal, E.B., Carroll, K.K. and Plunkett, E.R. Cancer Res. 27: 1737–1742, 1967.PubMedGoogle Scholar
  22. 22.
    Ip, C. Cancer Res. 40: 2785–2789, 1980.PubMedGoogle Scholar
  23. 23.
    Ip, C., Yip, P. and Bernardes, L.L. Cancer Res. 40: 374–378, 1980.PubMedGoogle Scholar
  24. 24.
    Chan, P.C. and Dao, T.L. Cancer Res. 41: 164–167, 1981.PubMedGoogle Scholar
  25. 25.
    Jurkowski, J.J. and Cave, W.T. J. Natl. Cancer Inst. 74: 1145–1150, 1985.PubMedGoogle Scholar
  26. 26.
    Engel, R.W. and Copeland, D.H. Cancer Res. 11: 180–183, 1951.PubMedGoogle Scholar
  27. 27.
    Silverman, J., Shellabarger, C.J., Holtzman, S., Stone, J.P. and Weisburger, J.H. J. Natl. Cancer Inst. 64: 631–634, 1980.PubMedGoogle Scholar
  28. 28.
    Ip, C. and Sinha, D. Cancer Letters 11: 277–283, 1981.PubMedCrossRefGoogle Scholar
  29. 29.
    Kollmorgen, G.M., Sansing, W.A., Lehman, A.A., Fischer, G., Longley, R.E., Alexander, S.S., King, M.M. and McCay, P.B. Cancer Res. 39: 3458–3462, 1979.PubMedGoogle Scholar
  30. 30.
    Ghayur, T. and Horrobin, D.F. IRCS Med. Sci. 9: 582, 1981.Google Scholar
  31. 31.
    Carroll, K.K. and Khor, H.T. Lipids 64: 415–420, 1971.CrossRefGoogle Scholar
  32. 32.
    Hopkins, G.J. and Carroll, K.K. J. Natl. Cancer Inst. 62: 1009–1012, 1979.PubMedGoogle Scholar
  33. 33.
    Kidwell, W.R., Monaco, M.E., Wicha, M.S. and Smith, G.S. Cancer Res. 38: 4091–4100, 1978.PubMedGoogle Scholar
  34. 34.
    Wicha, M.S., Liotta, L.A. and Kidwell, W.R. Cancer Res. 39: 426–435, 1979.PubMedGoogle Scholar
  35. 35.
    Selenskas, S.L., Ip, M.M. and Ip. C. Cancer Res. 44: 1321–1326, 1984.PubMedGoogle Scholar
  36. 36.
    Wetsel, W.C. and Rogers, A.E. J. Natl. Cancer Inst. 72: 531–536, 1984.Google Scholar
  37. 37.
    Rogers, A.E. Cancer Res. 43: 2477–2484, 1983.Google Scholar
  38. 38.
    Sylvester, P.W., Russell, M., Ip, M.M. and Ip, C. Cancer Res. 46: 757–762, 1986.PubMedGoogle Scholar
  39. 39.
    Kritchevisky, D., Weber, M.M. and Klurfeld, D.M. Cancer Res., 44: 3174–3177, 1984.Google Scholar
  40. 40.
    Carmel, N., Konijn, A.M., Kaufmann, N.A. and Guggenheim, K. J. Nutr. 105: 1141–1149, 1975.PubMedGoogle Scholar
  41. 41.
    Rabolli, D. and Marten, R.J. J. Nutr. 107: 1068–1074, 1977.PubMedGoogle Scholar
  42. 42.
    Abumrad, N.A., Stearns, S.B. and Tepperman, H.M. J. Lipid Res. 19: 423–432, 1978.PubMedGoogle Scholar
  43. 43.
    Blazquez, E. and Quijoda, C.L. J. Endocrinol. 42: 489–494, 1968.PubMedCrossRefGoogle Scholar
  44. 44.
    Cave, W.T., Dunn, J.T. and MacLeod, R.M. Cancer Res. 42: 729–734, 1979.Google Scholar
  45. 45.
    Chan, P.C., Head, J.F., Cohen, L.A. and Wynder, E.L. J. Natl. Cancer Inst. 59: 1279–1283, 1977.PubMedGoogle Scholar
  46. 46.
    Ip, C. and Ip, M.M. J. Natl. Cancer Inst. 66: 291–295, 1981.PubMedGoogle Scholar
  47. 47.
    Hopkins, G.J., Kennedy, T.G. and Carroll, K.K. J. Natl. Cancer Inst. 66: 517–522, 1981.PubMedGoogle Scholar
  48. 48.
    Wetsel, W.C., Rogers, A.E., Rutledge, A. and Leavitt, W.W. Cancer Res. 44: 1420–1425, 1984.PubMedGoogle Scholar
  49. 49.
    Chan, P.C., Didato, F. and Cohen, L.A. Proc. Soc. Exp. Biol. Med. 149: 133–135, 1975.PubMedGoogle Scholar
  50. 50.
    Hill, P., Chan, P., Cohen, L., Wynder, E. and Kuno, K. Cancer 39: 1820–1826, 1977.PubMedCrossRefGoogle Scholar
  51. 51.
    Carroll, K.K. Cancer Res. 41: 3695–3699, 1981.PubMedGoogle Scholar
  52. 52.
    Rogers, A.E. and Wetsel, W.C. Cancer Res. 41: 3735–3737, 1981.PubMedGoogle Scholar
  53. 53.
    Aylsworth, C.F., VanVugt, D.A., Sylvester, P.W. and Meites, J. Proc. Soc. Exp. Biol. Med. 175: 25–29, 1984.PubMedGoogle Scholar
  54. 54.
    Cohen, L.A., Chan, P.C. and Wynder, E.L. Cancer 47: 66–71, 1981.PubMedCrossRefGoogle Scholar
  55. 55.
    Hilf, R., Bell, C, Goldenberg, H. and Michel, I. Cancer Res. 31: 1111–1117, 1971.PubMedGoogle Scholar
  56. 56.
    Hilf, R., Michel, I., Bell, C, Freeman, J.J. and Borman, A. Cancer Res. 25: 286–299, 1965.PubMedGoogle Scholar
  57. 57.
    Aylsworth, C.F., VanVugt, D.A., Sylvester, P.W. and Meites, J. Cancer Res. 44: 2835–2840, 1984.PubMedGoogle Scholar
  58. 58.
    Martinez, C., Visscher, M.B., King, J.T. and Bittner, J.J. Proc. Soc. Exp. Biol. Med. 80: 81–83, 1952.PubMedGoogle Scholar
  59. 59.
    Sparks, L.L., Daane, T.A., Hayashida, T., Cole, R.D., Lyons, W.R. and Li, C.H. Cancer 8: 271–284, 1955.PubMedCrossRefGoogle Scholar
  60. 60.
    Aylsworth, C.F., Sylvester, P.W., Leung, F.C. and Meites, J. Cancer Res. 40: 1863–1866, 1980.PubMedGoogle Scholar
  61. 61.
    Heuson, J.C., Legros, N. and Hilman, R. Cancer Res. 21: 233–238, 1972.Google Scholar
  62. 62.
    Vonderhaar, B.K. and Greco, A.E. Endocrinology 104: 409–418, 1979.PubMedCrossRefGoogle Scholar
  63. 63.
    Sellitti, D.F., Tseng, Y.L. and Latham, K.R. Cancer Res. 41: 5015–5019, 1981.PubMedGoogle Scholar
  64. 64.
    Newman, W.C and Moon, R.C Cancer Res. 28: 864–868, 1968.PubMedGoogle Scholar
  65. 65.
    Welsch, C.W. Cancer Res. 45: 3415–3443, 1985.PubMedGoogle Scholar
  66. 66.
    Reddy, B.S., Watanabe, K. and Weisburger, J.H. Cancer Res. 37: 4156–4159, 1977.PubMedGoogle Scholar
  67. 67.
    El-Khateb, S.M. and Cora, E.M. J. Natl. Cancer Inst. 66: 297–301, 1981.Google Scholar
  68. 68.
    Roebuck, B.D., Yager, J.D., Longnecker, D.S. and Wilpone, S.A. Cancer Res. 41: 3961–3966, 1981.PubMedGoogle Scholar
  69. 69.
    Birt, D.F., Salmasi, S. and Pour, P.M. J. Natl. Cancer Inst. 67: 1327–1332, 1981.PubMedGoogle Scholar
  70. 70.
    Corwin, L.M., Varshavsky-Rose, F. and Broitman, S.A. Cancer Res. 39: 4350–4355, 1979.PubMedGoogle Scholar
  71. 71.
    Erickson, K.L. J. Natl. Cancer Inst. 72: 115–120, 1984.PubMedGoogle Scholar
  72. 72.
    Watson, A.F. and Mellanby, E. Brit. J. Exp. Pathol. 11: 311–322, 1930.Google Scholar
  73. 73.
    Birt, D.F. and Pour, P.M. J. Natl. Cancer Inst. 71: 401–406, 1983.PubMedGoogle Scholar
  74. 74.
    Beems, R.B. and vanBeek, L. Carcinogenesis 5: 413–417, 1984.PubMedCrossRefGoogle Scholar
  75. 75.
    Szepsenwol, J. Oncology 25: 143–152, 1978.CrossRefGoogle Scholar
  76. 76.
    Szepsenwol, J. Europ. J. Cancer 7: 529–532, 1971.Google Scholar
  77. 77.
    Miller, J.A. and Miller, E.C Adv. Cancer Res. 1:339–396, 1953.PubMedCrossRefGoogle Scholar
  78. 78.
    Birt, D.F. and Pour, P.M. J. Natl. Cancer Inst. 70:1135–1138, 1983.Google Scholar
  79. 79.
    Ip, M.M. and Ip, C. Nutr. Cancer 2: 27–34, 1981.CrossRefGoogle Scholar
  80. 80.
    Cave, W.T. and Erickson-Lucas, M.J. J. Natl. Cancer Inst. 68: 319–324, 1982.PubMedGoogle Scholar
  81. 81.
    Cave, W.T. and Jurkowski, J.J. J. Natl. Cancer Inst. 72: 185–191, 1984.Google Scholar
  82. 82.
    Knazek, R.A. and Liu, S.C Proc. Soc. Exp. Biol. Med. 162: 346–350, 1979.PubMedGoogle Scholar
  83. 83.
    Knazek, R.A., Liu, S.C., Bodwin, J.S. and Vonderhaar, B.K. J. Natl. Cancer Inst. 64: 377–382, 1980.PubMedGoogle Scholar
  84. 84.
    Knazek, R.A. and Liu, S.C. Cancer Res. 41: 3750–3751, 1981.PubMedGoogle Scholar
  85. 85.
    Mlyamoto-Tiaven, M.J., Hillyard, L.A. and Abraham, S. J. Natl. Cancer Inst. 62: 179–185, 1981.Google Scholar
  86. 86.
    Welsch, C.W., DeHoog, J.V., O’Connor, D.H. and Sheffield, L.G. Cancer Res. 45: 6147–6154, 1985.PubMedGoogle Scholar
  87. 87.
    White, F.R. Cancer Res. 21: 281–290, 1961.Google Scholar
  88. 88.
    Cohen, L.A., Thompson, D.O., Maeura, Y. and Weisburger, J.H. Cancer Res. 44: 5023–5028, 1984.PubMedGoogle Scholar
  89. 89.
    Ip, C. Cancer Res. 41: 2683–2686, 1981.Google Scholar
  90. 90.
    Donato, K. and Hegsted, D.M. Proc. Natl. Acad. Sci. (USA) 82: 4866–4870, 1985.CrossRefGoogle Scholar
  91. 91.
    Boissonneault, G.A., Elson, C.E. and Pariza, M.W. J. Natl. Cancer Inst. 76: 335–338, 1986.Google Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1989

Authors and Affiliations

  • C. Welsch
    • 1
  1. 1.Department of AnatomyMichigan State UniversityEast LansingUSA

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