The Role of Fatty Acids in Murine and Human Mammary Carcinogenesis: An InVitro Approach

  • N. T. Telang
  • R. S. Bockman
  • M. J. Modak
  • M. P. Osborne
Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 6)


Studies with animal models for mammary tumorigenesis have demonstrated that high levels of dietary fat influences the development of mammary tumors. In the mouse model mammary tumor development is initiated either by expression of preexisting mammary tumor virus (MTV) or by exposure to chemical carcinogens. While high levels of polyunsaturated omega-6 fatty acids are known to enhance spontaneous mammary tumor development, saturated fatty acids are inhibitory to tumor development in mice (1–3). Fatty acid-induced modulation has also been observed in transplantable mammary carcinomas in mice (4–6). Because of distinct strain-dependent differences in tumorigenesis in mice that are usually accompanied by a specific preneoplastic morphologic atypia, the effects of dietary modulators on mammary cell proliferation, differentiation and tumorigenic transformation have been extensively investigated.


Mammary Gland Mammary Tumor Chemical Carcinogen Mammary Tumorigenesis Terminal Duct Lobular Unit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers, Boston 1989

Authors and Affiliations

  • N. T. Telang
    • 1
  • R. S. Bockman
    • 2
  • M. J. Modak
    • 3
  • M. P. Osborne
    • 1
  1. 1.Breast Cancer Prevention Laboratory, Department of SurgeryMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Laboratory of Calcium MetabolismMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.Department of BiochemistryUniversity of Medicine & Dentistry of New JerseyNewarkUSA

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