The Role of Fatty Acids in Murine and Human Mammary Carcinogenesis: An InVitro Approach

  • N. T. Telang
  • R. S. Bockman
  • M. J. Modak
  • M. P. Osborne
Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 6)

Abstract

Studies with animal models for mammary tumorigenesis have demonstrated that high levels of dietary fat influences the development of mammary tumors. In the mouse model mammary tumor development is initiated either by expression of preexisting mammary tumor virus (MTV) or by exposure to chemical carcinogens. While high levels of polyunsaturated omega-6 fatty acids are known to enhance spontaneous mammary tumor development, saturated fatty acids are inhibitory to tumor development in mice (1–3). Fatty acid-induced modulation has also been observed in transplantable mammary carcinomas in mice (4–6). Because of distinct strain-dependent differences in tumorigenesis in mice that are usually accompanied by a specific preneoplastic morphologic atypia, the effects of dietary modulators on mammary cell proliferation, differentiation and tumorigenic transformation have been extensively investigated.

Keywords

Mammary Gland Mammary Tumor Chemical Carcinogen Mammary Tumorigenesis Terminal Duct Lobular Unit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Tinsley, J.J., Schmitz, J.A. and Pierce, D.A. Cancer Res. 41: 1460–1465, 1981.PubMedGoogle Scholar
  2. 2.
    Lane, H.W., Butel, J.S., Howard, C, Shepherd, F., Halligan, R. and Medina, D. Carcinogenesis 6:403–407, 1985.PubMedCrossRefGoogle Scholar
  3. 3.
    Bennett, A.S. Int. J. Cancer 34:529–533, 1984.PubMedCrossRefGoogle Scholar
  4. 4.
    Hillyard, L.A. and Abraham, S. Cancer Res. 39:4430–4437, 1979.PubMedGoogle Scholar
  5. 5.
    Rao, G.A. and Abraham, S. J. Natl. Cancer Inst. 56:431–432, 1976.PubMedGoogle Scholar
  6. 6.
    Hopkins, G.J., Hard, G.C. and West, C.E. J. Natl. Cancer Inst. 60:849–853, 1978.PubMedGoogle Scholar
  7. 7.
    Abraham, S. and Hillyard, L.A. J. Natl. Cancer Inst. 71:601–605, 1983.PubMedGoogle Scholar
  8. 8.
    Abraham, S., Faulkin, L.J., Hillyard, L.A. and Mitchell, D.J. J. Natl. Cancer Inst. 72: 1421–1429, 1984.PubMedGoogle Scholar
  9. 9.
    Gabor, H., Hillyard, L.A. and Abraham, S. J. Natl. Cancer Inst. 74:1299–1305, 1985.PubMedGoogle Scholar
  10. 10.
    Welsch, C.W., DeHoog, J.V., O’Connor, D.H. and Sheffield, L.G. Cancer Res. 45:6147–6154, 1985.PubMedGoogle Scholar
  11. 11.
    Welsch, C.W. In: Dietary Fat and Cancer (Eds. C. Ip, D.F. Birt, A.E. Rogers and C. Mettlin), A.R. Liss, New York, 1986, pp. 623–654.Google Scholar
  12. 12.
    Knazek, R.A., Liu, S.C., Bodwin, J.S. and Vonderhaar, B.K. J. Natl. Cancer Inst. 64:377–382, 1980.PubMedGoogle Scholar
  13. 13.
    Miyamoto-Tlaven, M.J., Hillyard, L.A. and Abraham, S. J. Natl. Cancer Inst. 67:179–188, 1981.Google Scholar
  14. 14.
    Faulkin, L.J., Abraham, S., Mitchell, D.J. and Hillyard, L.A. Proc. Soc. Exp. Biol. Med. 181:575–585, 1986.PubMedGoogle Scholar
  15. 15.
    Ichinose, R.R. and Nandi, S. J. Endocrinol. 35:331–340, 1966.PubMedCrossRefGoogle Scholar
  16. 16.
    Singh, D.V., DeOme, K.B. and Bern, H.A. J. Natl. Cancer Inst. 45:657–675, 1970.PubMedGoogle Scholar
  17. 17.
    Banerjee, M.R. Int. Rev. Cytol. 4:1–97, 1976.CrossRefGoogle Scholar
  18. 18.
    Banerjee, M.R., Ganguly, N., Mehta, N.M., Iyer, A.P. and Ganguly, R. In: Cell Biology of Breast Cancer (Eds. CM. McGrath, M. Brennan and M. Rich), Academic Press, New York, 1980, pp. 485–516.Google Scholar
  19. 19.
    Ganguly, N., Ganguly, R., Mehta, N.M., Crump, L.R. and Banerjee, M.R. In Vitro 17:55–60, 1981.PubMedCrossRefGoogle Scholar
  20. 20.
    Banerjee, M.R. and Antoniou, M. In: Cell Culture Methods for Molecular and Cell Biology II (Eds. D.W. Barnes, D.A. Sirbasku and G.H. Sato), A.R. Liss, New York, 1984, pp. 143–169.Google Scholar
  21. 21.
    Lin, F.K., Banerjee, M.R. and Crump, L.R. Cancer Res. 36:1607–1614, 1976.PubMedGoogle Scholar
  22. 22.
    Kundu, A.B., Telang, N.T. and Banerjee, M.R. J. Natl. Cancer Inst. 61:465–469, 1978.PubMedGoogle Scholar
  23. 23.
    Tonnelli, Q.J., Custer, R.P. and’Sorof, S. Cancer Res. 39:1784–1792, 1979.Google Scholar
  24. 24.
    Telang, N.T., Banerjee, M.R., Iyer, A.P. and Kundu, A.B. Proc. Natl. Acad. Sci. U.S.A. 76:5886–5890, 1979.PubMedCrossRefGoogle Scholar
  25. 25.
    Iyer, A.P. and Banerjee, M.R. J. Natl. Cancer Inst. 66:893–905, 1981.PubMedGoogle Scholar
  26. 26.
    Nandi, S. and McGrath, C.M. Adv. Cancer Res. 17:354–414, 1973.Google Scholar
  27. 27.
    Medina, D. Cancer Res. 36:3584–3595, 1976.Google Scholar
  28. 28.
    Telang, N.T. and Sarkar, N.H. In: Modulation and Mediation of Cancer by Vitamins (Eds. F.L. Miyskens and K.N. Prasad), S. Karger, New York, 1983, pp. 67–77.Google Scholar
  29. 29.
    Telang, N.T. and Sarkar, N.H. Cancer Res. 43:4891–4900, 1983.PubMedGoogle Scholar
  30. 30.
    Telang, N.T. In: Dietary Fat and Cancer (Eds. C. Ip, D.F. Birt, A.E. Rogers and C Mettlin), A.R. Liss, New York, 1986, pp. 707–728.Google Scholar
  31. 31.
    Welsch, C.W. Cancer Res. 45:3415–3443, 1985.PubMedGoogle Scholar
  32. 32.
    Welsch, C.W., Zile, M.H. and Cullum, M.E. In: Diet, Nutrition and Cancer: A Critical Evaluation (Eds. B.S. Reddy and L.A. Cohen), CRC Press, Boca Raton, FL, 1986, pp. 1–21.Google Scholar
  33. 33.
    Mehta, R.G., Cerny, W.L. and Moon, R.C Carcinogenesis 4:23–26, 1983.PubMedCrossRefGoogle Scholar
  34. 34.
    Kistler, A. Carcinogenesis 7:1175–1182, 1986.PubMedCrossRefGoogle Scholar
  35. 35.
    Telang, N.T. and Sarkar, N.H. Proc. Am. Assoc. Cancer Res. 27:939, 1986.Google Scholar
  36. 36.
    Banerjee, M.R. In: In Vitro Models for Cancer Research (Eds. M.M. Weber and M. Sekeley), CRC Press, Boca Raton, FL, 1986, pp. 69–114.Google Scholar
  37. 37.
    Telang, N.T., Bockman, R.S. and Sarkar, N.H. Carcinogenesis 5:1123–1127, 1984.PubMedCrossRefGoogle Scholar
  38. 38.
    Telang, N.T., Basu, A., Modak, M.J. and Osborne, M.P. Fed. Proc. 46:582, 1987.Google Scholar
  39. 39.
    Banerjee, M.R., Wood, B.G. and Washburn, L.L. J. Natl. Cancer Inst. 53; 1387–1393, 1974.PubMedGoogle Scholar
  40. 40.
    Ono, M. and Oka, T. Cell 19:473–480, 1980.PubMedCrossRefGoogle Scholar
  41. 41.
    Mehta, N.M., Ganguly, N., Ganguly, R. and Banerjee, M.R. J. Biol. Chem. 255:4430–4434, 1980.PubMedGoogle Scholar
  42. 42.
    Schaeffer, F.V., Custer, R.P. and Sorof, S. Cancer Res. 43:279–286, 1983.Google Scholar
  43. 43.
    Calaf, G., Russo, I.H., Roi, L.D. and Russo, J. In Vitro Cell. Dev. Biol. 22:135–140, 1986.PubMedCrossRefGoogle Scholar
  44. 44.
    Russo, J., Calaf, G., Roi, L. and Russo, I.H. J. Natl. Cancer Inst. 78:413–418, 1987.PubMedGoogle Scholar
  45. 45.
    Axelrod, D.M., Telang, N.T., Rosen, P.P. and Osborne, M.P. Proc. Am. Assoc. Cancer Res. 27:30, 1986.Google Scholar
  46. 46.
    Axelrod, D.M., Telang, N.T., Bradlow, H.L. and Osborne, M.P. Breast Cancer Res. Treat. 8:108, 1986.Google Scholar
  47. 47.
    Yang, J. and Nandi, S. Int. Rev. Cytol. 81:249–286, 1983.PubMedCrossRefGoogle Scholar
  48. 48.
    Imagawa, W., Tomooka, Y., Yang, J., Guzman, R., Richards, J. and Nandi, S. In: Cell Culture Methods for Molecular Cell Biology II (Eds. D.W. Barnes, D.A. Sirbasku and G.H. Sato), A.R. Liss, New York, 1984, pp. 127–141.Google Scholar
  49. 49.
    Imagawa, W., Tomooka, Y., Hamamoto, S. and Nandi, S. Endocrinology 116:1514–1524, 1985.PubMedCrossRefGoogle Scholar
  50. 50.
    Guzman, R.C., Osborn, R.C., Bartley, J.C., Imagawa, W., Asch, B.B. and Nandi, S. Cancer Res. 47:275–280, 1987.PubMedGoogle Scholar
  51. 51.
    Bandyopadhyay, G.K., Imagawa, W., Wallace, D.W. and Nandi, S. J. Biol. Chem. 262:2750–2756, 1987.PubMedGoogle Scholar
  52. 52.
    DeOme, K.B., Faulkin, L.J. and Bern, H.A. Cancer Res. 19:515–520, 1959.PubMedGoogle Scholar
  53. 53.
    DeOme, K.B., Osborn, R.C., Miyamoto, M.J. and Guzman, R.C. In: Cell Biology of Breast Cancer (Eds. CM. McGrath, M.J. Brennan and M.A. Rich), Academic Press, New York, 1980, pp. 79–91.Google Scholar
  54. 54.
    Ethier, S.P. and Ullrich, R.L. Cancer Res. 44:4523–4527, 1984.PubMedGoogle Scholar
  55. 55.
    Guzman, R.C, Osborn, R.C. and DeOme, K.B. Cancer Res. 41:1808–1811, 1981.PubMedGoogle Scholar
  56. 56.
    Manoharan, K. and Banerjee, M.R. Mutat. Res. 147: 165–169, 1985.PubMedGoogle Scholar
  57. 57.
    Menon, R., Bartley, J., Som, S. and Banerjee, M.R. Eur. J. Cancer Clin. Oncol. 23:395–400, 1987.PubMedCrossRefGoogle Scholar
  58. 58.
    Telang, N.T. and Sarkar, N.H. In Vitro Cell. Dev. Biol. 22:120, 1986.CrossRefGoogle Scholar
  59. 59.
    Williams, G.M. Ann. N.Y. Acad. Sci. 349:273–282, 1980.PubMedCrossRefGoogle Scholar
  60. 60.
    Reiss, B., Telang, N.T. and Williams, G.M. In: Experimental Colon Carcinogenesis (Eds. H. Autrup and G.M. Williams), CRC Press, Boca Raton, FL, 1983, pp. 83–94.Google Scholar
  61. 61.
    Tong, C., Telang, S. and Williams, G.M. Mutat. Res. 130:53–61, 1984.PubMedGoogle Scholar
  62. 62.
    Bodell, W.J. and Banerjee, M.R. Nucleic Acids Res. 3:1689–1701, 1976.PubMedGoogle Scholar
  63. 63.
    Som, S., Chatterjee, M. and Banerjee, M.R. Carcinogenesis 5:937–940, 1984.PubMedCrossRefGoogle Scholar
  64. 64.
    Chatterjee, M. and Banerjee, M.R. Carcinogenesis 3:801–804, 1982.PubMedCrossRefGoogle Scholar
  65. 65.
    Jurokowski, J.J. and Cave, W.T. J. Natl. Cancer Inst. 74:1145–1150, 1985.Google Scholar
  66. 66.
    Karmali, R.A., Marsh, J. and Fuchs, C. J. Natl. Cancer Inst. 73:457–461, 1984.PubMedGoogle Scholar
  67. 67.
    Karmali, R.A. In: Dietary Fat and Cancer (Eds. C. Ip, D.F. Birt, A.E. Rogers and C. Mettlin), A.R. Liss, New York, 1986, pp. 687–697.Google Scholar
  68. 68.
    Zarbl, H., Sukumar, S., Arthur, A.V., Martin-Zance, D. and Barbacid, M. Nature (London) 315:382–385, 1985.CrossRefGoogle Scholar
  69. 69.
    Kraus, M.H., Yuasa, Y. and Aronson, S.A. Proc. Natl. Acad. Sci. U.S.A. 81: 5384–5388, 1984.PubMedCrossRefGoogle Scholar
  70. 70.
    Dandekar, S., Sukumar, S., Zarbl, H., Young, L.J.T. and Cardiff, R.D. Mol. Cell. Biol. 6:4104–4108, 1986.PubMedGoogle Scholar
  71. 71.
    Reddy, E.P., Reynolds, R.K., Santos, E. and Barbacid, M. Nature (London) 300:149–152, 1982.CrossRefGoogle Scholar
  72. 72.
    DeBertoli, M.E., Abou-Issa, H., Haley, B.E. and Cho-Chung, Y.S. Biochem. Biophys. Res. Commun. 127:699–706, 1984.CrossRefGoogle Scholar
  73. 73.
    Varmus, H.E. Annu. Rev. Genet. 18:553–612, 1984.PubMedCrossRefGoogle Scholar
  74. 74.
    Telang, N.T., Kurihara, H., Bradlow, H.L. and Osborne, M.P. Proc. Am. Assoc. Cancer Res. 28:938, 1987.Google Scholar
  75. 75.
    Telang, N., Basu, A., Kurihara, H., Axelrod, D., Modak, M. and Osborne, M. Breast Cancer Res. Treat. 9:28, 1987Google Scholar
  76. 76.
    Mauvais-Jarvis, P., Kuttenn, F. and Gompel, A. Breast Cancer Treat. 8:179–187, 1986.CrossRefGoogle Scholar
  77. 77.
    Stampfer, M.R. and Bartley, J.C. Proc. Natl. Acad. Sci. U.S.A. 82: 2394–2398, 1985.PubMedCrossRefGoogle Scholar
  78. 78.
    Stampfer, M., Barthotomew, J., Smith, H.S. and Bartley, J.C. Proc. Natl. Acad. Sci. U.S.A. 78:6251–6255, 1981.PubMedCrossRefGoogle Scholar
  79. 79.
    Harris, C. Cancer Res. 47:1–10, 1987.PubMedGoogle Scholar
  80. 80.
    Bartley, J.C. and Stampfer, M.R. Carcinogenesis 6:1017–1022, 1985.PubMedCrossRefGoogle Scholar
  81. 81.
    Moore, C.J., Eldrich, S.R., Tricomi, W.A. and Gould, M.N. Cancer Res. 47:2609–2613, 1987.PubMedGoogle Scholar
  82. 82.
    Moore, C.J., Pruess-Schwartz, D., Marthe, R.J., Gould, M.N. and Baird, W.M. Cancer Res. 47: 4402–4406, 1987.PubMedGoogle Scholar
  83. 83.
    Russo, J., Mousalli, M., Koszalka, M. and Russo, I.H. Proc. Am. Assoc. Cancer Res. 28:119, 1987.Google Scholar
  84. 84.
    Basu, A. and Modak, M.J. J. Biol. Chem. 262:2369–2373, 1987.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1989

Authors and Affiliations

  • N. T. Telang
    • 1
  • R. S. Bockman
    • 2
  • M. J. Modak
    • 3
  • M. P. Osborne
    • 1
  1. 1.Breast Cancer Prevention Laboratory, Department of SurgeryMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Laboratory of Calcium MetabolismMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.Department of BiochemistryUniversity of Medicine & Dentistry of New JerseyNewarkUSA

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