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Regulation of Tumor Cell Adhesion and Motility by Arachidonic Acid Metabolism

  • J. Varani
Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 6)

Abstract

During the process of tumor cell invasion, malignant cells interact with the host extracellular matrix. Both adhesion of the cells to matrix components and cell motility are involved. These interactions are mediated through specific receptors on the tumor cell surface for extracellular matrix components. While matrix components such as laminin and fibronectin may facilitate adhesion and motility by providing a substratum on which these processes can occur, recent studies have shown that the binding of these molecules to the tumor cell surface also induces a transmembrane signal. Arachidonic acid is released from phospholipid pools in the stimulated cells and converted into a number of metabolites of both the lipoxygenase and cyclooxygenase pathways. These metabolites directly influence adhesion and motility as positive and negative regulators. Quantitative differences in arachidonic acid metabolism among closely-related tumor cell lines contribute to differences in biological responsiveness. These results suggest that high molecular weight extracellular matrix components can influence tumor cell behavior in a similar manner to low molecular weight chemotactic factors.

Keywords

Arachidonic Acid Arachidonic Acid Metabolism Arachidonic Acid Metabolite Tumor Cell Adhesion Arachidonic Acid Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers, Boston 1989

Authors and Affiliations

  • J. Varani
    • 1
  1. 1.Department of PathologyThe University of Michigan Medical SchoolAnn ArborUSA

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