Prostaglandins and Tumor Metastasis

  • Amy M. Fulton
Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 6)


There is considerable evidence that lipids, and specifically prostaglandins (pgs), can contribute to progressive tumor growth (1). Many studies provide evidence that lipids can contribute to early steps in carcinogenesis, in particular early promotional events. Recently, efforts have been directed towards examining the contribution prostaglandins make to the successful metastasis of tumor cells from the primary site. For breast cancer, perhaps more so than any other type of malignancy, prevention of metastasis is the ultimate clinical problem. It is also in this disease that some of the earliest evidence for a role for prostaglandins has been provided.


Lewis Lung Carcinoma Experimental Metastasis Spontaneous Metastasis Prostaglandin Synthesis Inhibitor Amelanotic Melanoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Abraham, S., Fauklin, L.J., Hillyard, L.A. and Mitchell, D.J. J. Nati. Cancer Inst. 72:1421–1429, 1984.Google Scholar
  2. 2.
    Bennett, A., Charlier, E.M., McDonald, A.M., Simpson, J.S., Stamford, I.F. and Zebro, T. Lancet 2:624–626, 1977.PubMedCrossRefGoogle Scholar
  3. 3.
    Bennett, A., Berstock, D.A., Raja, B. and Stamford, I.F. Br. J. Pharmacol. 66:451, 1979.Google Scholar
  4. 4.
    Powles, T.J., Dowsett, M., Easty, D.M., Easty, G.C. and Neville, A.M. Lancet 1:608–610, 1976.PubMedCrossRefGoogle Scholar
  5. 5.
    Dady, P.J., Powles, T.J., Dowsett, M., Easty, G., Williams, J. and Neville, A.M. Br. J. Cancer 43:222–225, 1981.PubMedCrossRefGoogle Scholar
  6. 6.
    Rolland, P.H., Martin, P.M., Jacquemier, J., Rolland, A.M. and Toga, M. J. Natl. Cancer Inst. 64:1061–1070, 1980.Google Scholar
  7. 7.
    Malachi, T., Chaimoff, Ch., Feller, N. and Halbrecht, I.J. Cancer Res. Clin. Oncol. 102:71–79, 1981.CrossRefGoogle Scholar
  8. 8.
    Hortobagyi, G.N., Schultz, P., Cailleau, R., Samaan, N. and Blumenschein, G. In: Prostaglandins and Cancer: First International Conference (Eds. T.W. Powles, R.F. Bockman, K.V. Honn), Alan R. Liss, Inc., New York, 1982, pp. 567–572.Google Scholar
  9. 9.
    Gunasegaram, R., Loganath, A., Peh, K.L., Chiang, S.C. and Ratnam, S.S. IRCS Med. Sci. 8:747–748, 1981.Google Scholar
  10. 10.
    Bishop, H.M., Haynes, J., Evans, D.F., Elston, C.W., Johnson, J. and Blarney, R.W. Clin. Oncol. 6:380–381, 1980.Google Scholar
  11. 11.
    Kibbey, W.E., Bronn, D.G. and Minton, J.P. Prostagl. Medicine 2:133–139, 1979.CrossRefGoogle Scholar
  12. 12.
    Fulton, A., Roi, L., Howard, L, Russo, J., Brooks, S.C. and Brennan, M.J. Breast Cancer Res. Treatment 2:331–337, 1982.CrossRefGoogle Scholar
  13. 13.
    Fulton, A.M., Ownby, H.E., Frederick, J. and Brennan, M.J. Invasion Metastasis 6:83–94,1986.PubMedGoogle Scholar
  14. 14.
    Watson, D.M.A., Kelly, R.W., Hawkins, R.A. and Miller, W.R. Br. J. Cancer 49:459–464, 1984.PubMedCrossRefGoogle Scholar
  15. 15.
    Vergote, I.B., Laekeman, G.M., Keersmaekers, G.H., Uyttenbroeck, F.L., Vanderheyden, J.S., Albertyn, G.P., Haensch, C.F., DeRoy, G.J. and Herman, A.G. Br. J. Cancer 51:827–836, 1985.PubMedCrossRefGoogle Scholar
  16. 16.
    Bennett, A. In: Icosanoids and Cancer (Eds. H. Thaler-Dao, A. de Paulet, and R. Paoletti), Raven Press, New York, 1984, pp. 223–228.Google Scholar
  17. 17.
    Karmali, R.A., Walt, S., Thaler, H.T. and Lefevre, F. Br. J. Cancer 48:689–696, 1983.PubMedCrossRefGoogle Scholar
  18. 18.
    Aitokallio-Talberg, A., Karkkainen, J., Pantzar, P., Wahlstrom, T. and Ylikorkala, O. Br. J. Cancer 51:671–674, 1985.CrossRefGoogle Scholar
  19. 19.
    Fitzpatrick, F.A. and Stringfellow, D.A. Proc. Natl. Acad. Sci. 76:1765–1769, 1979.PubMedCrossRefGoogle Scholar
  20. 20.
    Stringfellow, D.A. and Fitzpatrick, F.A. Nature 282:76–78, 1979.PubMedCrossRefGoogle Scholar
  21. 21.
    Miller, F.R., Miller, B.E. and Heppner, G.H. Invasion Metastasis 3:22–31,1983.PubMedGoogle Scholar
  22. 22.
    Fulton, A.M. and Heppner, G.H. Cancer Res. 45:4779–4784, 1985.PubMedGoogle Scholar
  23. 23.
    Fulton, A.M. J. Natl. Cancer Inst. 78:735–741, 1987.PubMedGoogle Scholar
  24. 24.
    Gasic, G.J., Gasic, T.B., Galanti, N., Johnson, T. and Murphy, S. Int. J. Cancer 11:704–718, 1973.PubMedCrossRefGoogle Scholar
  25. 25.
    Drago, J.R. and Al-Mondhiry, H.A.B. Anticancer Res. 4:391–394, 1984.PubMedGoogle Scholar
  26. 26.
    Kort, W.J., Hulsman, O.M., Van Schalkwijk, W.P., Weijma, I.M., Zondervan, P.E. and Westbroek, D.L. J. Natl. Cancer Inst. 76:711–720, 1986.PubMedGoogle Scholar
  27. 27.
    Mahan, M., Meunier, J., Newby, M. and Young, M.R. J. Natl. Cancer Inst. 74:191–195, 1985.PubMedGoogle Scholar
  28. 28.
    Young, M.R., Young, M.E. and Wepsic, H.T. Cancer Res. 47:3679–3683, 1987.PubMedGoogle Scholar
  29. 29.
    Fligiel, S.E.G., Perone, P. and Varani, J. Int. J. Cancer 36:383–388, 1985.PubMedGoogle Scholar
  30. 30.
    Botha, J.H., Robinson, K.M., Ramchurren, N., Reddi, K. and Norman, R.J. J. Natl. Cancer Inst. 76:1053–1056, 1986.PubMedGoogle Scholar
  31. 31.
    Young, M.R. and Newby, M. Cancer Res. 46:160–164, 1986.PubMedGoogle Scholar
  32. 32.
    Mahoney, K.H., Fulton, A.M. and Heppner, G.H. J. Immunol. 131:2079–2085, 1983.PubMedGoogle Scholar
  33. 33.
    Fulton, A.M. Int. J. Cancer 33:375–379, 1984.PubMedCrossRefGoogle Scholar
  34. 34.
    Goodwin, J.S. and Ceuppens, J. J. Clin. Immunol. 3:295–315, 1983.CrossRefGoogle Scholar
  35. 35.
    Webb, D.R. and Nowowiejski, I. Cell. Immunol. 41:72–80, 1978.PubMedCrossRefGoogle Scholar
  36. 36.
    Hanna, N. and Fidler, I.J. J. Natl. Cancer Inst. 65:801–809, 1980.PubMedGoogle Scholar
  37. 37.
    Gorelik, E., Wiltrout, R.H., Okumura, K., Habu, S. and Herberman, R. Int. J. Cancer 30:107–112, 1982.PubMedCrossRefGoogle Scholar
  38. 38.
    Parhar, R.S. and Lala, P.K. Cell. Immunol. 93:265–279, 1985.PubMedCrossRefGoogle Scholar
  39. 39.
    Young, M.R., Wheeler, E. and Newby, M. J. Natl. Cancer Inst. 76:745–750, 1986.PubMedGoogle Scholar
  40. 40.
    Yamashina, K., Fulton, A. and Heppner, G. J. Natl. Cancer Inst. 75:765–770, 1985.Google Scholar
  41. 41.
    Gasic, G.J., Tuszynski, G.P. and Gorelik, E. Int. Rev. Expt. Pathol. 29:173–212, 1986.Google Scholar
  42. 42.
    Honn, K.V., Cicone, B. and Skoff, A. Science 212:1270–1272, 1981.PubMedCrossRefGoogle Scholar
  43. 43.
    Honn, K.V., Busse, W.D. and Sloane, B.F. Biochem. Pharmacol. 32:1–11, 1983.PubMedCrossRefGoogle Scholar
  44. 44.
    Karpatkin, S. Ambrogio, C. and Pearlstein, E. Cancer Res. 44:3880–3883, 1984.PubMedGoogle Scholar
  45. 45.
    Haas, J.S., Corbett, T.H. and Haas, C.D. Proc. AACR 26:51, 1985.Google Scholar
  46. 46.
    Vicenzi, E., Lampugnani, M.G., Dalessandro, A.P.B., Niewiarowska, A., de Gaetano, G. and Donati, M.B. Int. J. Cancer 19:488–491, 1987.CrossRefGoogle Scholar
  47. 47.
    Chiabrondo, C., Broggini, M., Castelli, M.G., Cozzi, E., Castagnoli, M.N., Donelli, M.G., Garattini, S., Giavazzi, R. and Favelli, R. Cancer Res. 47:988–991, 1987.Google Scholar
  48. 48.
    Estrada, J. and Nicholsen, G.L. Int. J. Cancer 34:101–105, 1984.PubMedCrossRefGoogle Scholar
  49. 49.
    Grignani, G., Pacchiarini, L., Almasio, P., Pagliarino, M., Gamba, G., Rizzo, S.C. and Ascari. E. Int. J. Cancer 38:237–244, 1986.PubMedCrossRefGoogle Scholar
  50. 50.
    Fantone, J.C., Elgas, L.J., Weinberger, L. and Varani, J. Oncol. 40:421–426, 1983.CrossRefGoogle Scholar
  51. 51.
    Bregman, M.D., Funk, C. and Fukushima, M.I. Cancer Res. 46:2740–2744, 1986.PubMedGoogle Scholar
  52. 52.
    Karmali, R.A., Horrobin, D.F., Menezes, J. and Patel, P. Pharmacol. Res. Comm. 11:69–75, 1979.CrossRefGoogle Scholar
  53. 53.
    Kantor, H.S. and Hampton, M. Nature 276:841–842, 1978.PubMedCrossRefGoogle Scholar
  54. 54.
    Rudland, P.S., Twiston-Davies, A.C. and Tsao, S.-W. J. Celi. Physiol. 120:364–376, 1984.CrossRefGoogle Scholar
  55. 55.
    McCormick, D.L., Madigan, M.J. and Moon, R.C. Cancer Res. 45:1803–1808, 1985.PubMedGoogle Scholar
  56. 56.
    Anderson, W.B., Gallo, M. and Pastan, I. J. Biol. Chem. 22:7041–7048, 1974.Google Scholar
  57. 57.
    Watanabe, T., Umegaki, K. and Smith, W.L. J. Biol. Chem. 261:13430–13439, 1986.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1989

Authors and Affiliations

  • Amy M. Fulton
    • 1
  1. 1.E. Walter Albachten Department of ImmunologyMichigan Cancer FoundationDetroitUSA

Personalised recommendations