Autoxidation Products and Intestinal Carcinogenesis

  • Arthur W. Bull
  • Norman D. Nigro
  • Lawrence J. Marnett
Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 6)

Abstract

Cancer of the large bowel is one of the most prevalent forms of neoplastic disease in North America (1). There has been a vast amount of research on the etiology of the disease but the exact cause has not been determined. Nonetheless, a number of factors which influence the risk and progression of large bowel cancer have been identified. A small percentage of large bowel cancer is genetic in origin such as that arising in individuals afflicted with familial polyposis (2). However, the great majority of cases of large bowel cancer are of unknown origin and strongly influenced by environmental factors. The major environmental factor affecting large bowel carcinogenesis is the diet and the most important dietary factor that enhances cancer appears to be the level of fat. The focus of the present chapter concerns a potential mechanism by which dietary fat influences colon carcinogenesis.

Keywords

Superoxide Ketone Luminal Indomethacin Hydroperoxide 

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Copyright information

© Kluwer Academic Publishers, Boston 1989

Authors and Affiliations

  • Arthur W. Bull
  • Norman D. Nigro
  • Lawrence J. Marnett

There are no affiliations available

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