The Role of Membrane-Stabilizing Drugs on Uptake of Leishmania Parasites by Human Macrophages
More than 12 million people are infected with different species of Leishmania and the annual death toll due to leishmaniasis is over 5000. Treatment of the patients with different forms of leishmaniasis is still a serious problem. Pentavalent antimonials in conventional doses are ineffective against visceral leishmaniasis and at higher doses toxic. The usual second line drugs such as pentamidine and amphotericin B are also toxic and difficult to administer. There is therefore a great need to search for drugs that are safe and can ef¬fectively control the disease.
KeywordsVisceral Leishmaniasis Trypanosoma Brucei Antileishmanial Activity Lipid Fluidity Leishmania Donovani
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