Abstract
The murine model of infection with L.major represents an important system for the analysis of the cellular parameters which entail susceptibility or resistance to infection with L.major. Indeed, depending on the genetic background of the mice, the entire spectrum of the clinical manifestations observed in human leishmaniasis can be seen. After s.c. infection with L.major, resistant mice (e.g. CBA) develop locally small lesions which resolve spontaneously whereas in susceptible mice (e.g. BALB/c) these lesions are much more severe, do not heal and viserali-sation occurs (1, 2).
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Pedrazzini, T., Kindler, V., Vassalli, P., Marchal, G., Milon, G., Louis, J.A. (1989). The Role of Specific T Cell Subsets in the Immunological Control of Experimental Cutaneous Leishmaniasis. In: Hart, D.T. (eds) Leishmaniasis. NATO ASI Series, vol 171. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1575-9_40
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DOI: https://doi.org/10.1007/978-1-4613-1575-9_40
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