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Antigens Recognized by Sera from Patients with Visceral Leishmaniasis

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Leishmaniasis

Part of the book series: NATO ASI Series ((NSSA,volume 171))

Abstract

Visceral leishmaniasis is a fatal disease, generally caused by the parasite Leishmania donovanl. This disease is typified by anemia, Irregular fever and hepatosplenomegaly1,2. Patients with visceral leishmaniasis are immunosuppressed and fail to mount delayed-type skin hypersensitivity reactions to leishmanial antigen. However, hyperglobulinemia is a characteristic feature of the disease and globulin levels as high as 5g per 100 ml have been noted. Although leishmanial specific antibodies are present most of the antibody is not parasite specific and is thought to result from polyclonal B cell stimulation.1–3

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Author information

Authors and Affiliations

  1. Department of Biophysics - MacArthur Center for Molecular Biology of Tropical Diseases, Weizmann Institute of Science, Rehovot, Israel

    Charles L. Jaffe, Mariano Zalis & Nurit Rachamim

  2. Research Unit of Autoimmune Diseases, Dept. of Medicine D’, Soroka Medical Center, Beersheva, Israel

    Shmuel Argov, Margalit Krup & Yehuda Shoenfeld

Authors
  1. Charles L. Jaffe
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  2. Shmuel Argov
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  3. Mariano Zalis
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  4. Nurit Rachamim
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  5. Margalit Krup
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  6. Yehuda Shoenfeld
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Editor information

Editors and Affiliations

  1. King’s College London, London, UK

    D. T. Hart

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© 1989 Springer Science+Business Media New York

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Jaffe, C.L., Argov, S., Zalis, M., Rachamim, N., Krup, M., Shoenfeld, Y. (1989). Antigens Recognized by Sera from Patients with Visceral Leishmaniasis. In: Hart, D.T. (eds) Leishmaniasis. NATO ASI Series, vol 171. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1575-9_36

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  • DOI: https://doi.org/10.1007/978-1-4613-1575-9_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8862-6

  • Online ISBN: 978-1-4613-1575-9

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