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Protein Stability and Function

Theoretical Studies
  • J. Andrew McCammon
  • Chung F. Wong
  • Terry P. Lybrand

Abstract

The convergence of several lines of development in chemistry and molecular biology has created major new needs and opportunities for theoretical studies of proteins. The traditional approaches of organic synthesis have been supplemented by methods for automated chemical synthesis and genetic engineering that allow the preparation of a wide variety of polypeptides, specifically altered enzymes, and other complex molecules. The choice of molecules to be synthesis for a given application is increasingly guided by structural information in addition to traditional methods such as chemical intuition and empirical correlation (quantitative structure-activity relationships, or QSAR). X-ray area detectors and new methods in NMR spectroscopy, combined with the improvements in our ability to synthesize and purify samples, are increasingly the rate at which high-resolution structures to proteins are becoming available.

Keywords

Kcal Mole Protein Stability Free Energy Change Thermodynamic Cycle Relative Free Energy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • J. Andrew McCammon
    • 1
  • Chung F. Wong
    • 1
  • Terry P. Lybrand
    • 1
  1. 1.Department of ChemistryUniversity of HoustonHoustonUSA

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