Nature of Radiation Induced Mutations: Experimental Approaches on the Question of Intragenic Events

  • E. G. Sideris
Part of the Nato ASI Series book series (NSSA, volume 154)


The question on the nature of radiation induced mutations arose at the very early days of radiation genetics. According to H.J. Muller (1954) who founded the radiation genetics, working with the fruitfly Drosophila “it was evident practically from the start that gene mutations were being produced by ionizing radiation”. With the term gene mutation Muller meant permanent heritable changes in individual genes, which is quite close to what in our days we call intragenic mutations including the true point mutations i.e. changes of single nucleotides in the DNA molecule. On the other hand Stadler (1932) working independently with maize was led to the conclusion that ionizing radiation, and particularly X-rays, induce mainly chromosome aberrations that is mainly multigene deficiencies or other types of chromosome aberrations. The work of Stadler and his associates led to the conclusion that the great majority if not all of the induced mutations by X-rays in maize and probably other cereals were structural chromosome changes and not intragenic events.


Chromosome Aberration Mouse Oocyte Intragenic Event Chinese Hamster Cell Adenine Phosphoribosyl Transferase 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • E. G. Sideris
    • 1
  1. 1.Radiation Mutagenesis Project, Institute of BiologyNational Research Center “Demokritos”AthensGreece

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