The Cell Biology of Antigen Processing: A Review

  • G. K. Lewis
Part of the Developments in Medical Virology book series (DIMV, volume 6)


In the last 13 years the major mechanisms whereby the immune system generates an extremely large number of different antibodies and T cell antigen receptors were identified. By contrast, it is only in the last 4 years that any detailed understanding of a third aspect of antigen recognition has emerged; namely, how an antigen presenting cell creates a specific ligand for recognition by the T cell antigen receptor. Fortunately, the methods of molecular and cell biology, combined with current immunological paradigms, offer a unique opportunity to attack the mechanisms of antigen presentation. The following review will attempt to place antigen processing in the context of our current knowledge of the expression of the MHC molecules that serve as “receptors” for immunogenic peptides on the antigen presenting cell (APC) side of an immunologic cell couple.


Influenza Virus Antigen Present Cell Antigenic Peptide Protein Antigen Antigen Processing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Kluwer Academic Publishers 1990

Authors and Affiliations

  • G. K. Lewis
    • 1
  1. 1.Department of Microbiology and ImmunologyUniversity of Maryland School of MedicineBaltimoreUSA

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