Do We Need Any More Antihypertensive Drugs: The Validity of a Change in Blood Pressure as the Only Endpoint for Approvability
A change in blood pressure is likely the only practical criterion, along with apparent safety, for approval of a new antihypertensive agent. However, there is a hierarchy of possible and potential endpoints beyond simple antihypertensive efficacy than can be considered as criteria for approvability (Table). Brief consideration will be given to each of these, starting from the bottom and proceeding upward.
KeywordsPlacebo Ischemia Expense Hines
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