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Do We Need Any More Antihypertensive Drugs: The Validity of a Change in Blood Pressure as the Only Endpoint for Approvability

  • N. M. Kaplan
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 112)

Abstract

A change in blood pressure is likely the only practical criterion, along with apparent safety, for approval of a new antihypertensive agent. However, there is a hierarchy of possible and potential endpoints beyond simple antihypertensive efficacy than can be considered as criteria for approvability (Table). Brief consideration will be given to each of these, starting from the bottom and proceeding upward.

Keywords

Antihypertensive Drug Antihypertensive Agent Additional Criterion Target Organ Damage Cardiovascular Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • N. M. Kaplan
    • 1
  1. 1.Department of Internal MedicineThe University of Texas Southwestern Medical CenterDallasUSA

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