Central nervous system (CNS) metastases from systemic cancer are usually separated into two distinct anatomic categories depending on whether they arise in the extradural or intradural spaces. The biology of metastasis differs for each of these locations, and each cancer has its own pattern of spread. Extradural or epidural metastases usually arise from a metastasis involving bone adjacent to a neural structure or from venous plexuses or lymph channels in the extradural space (figure 20-1). Intradural metastases may involve the leptomeninges, brain, or spinal cord, and are usually of hematogenous origin. This chapter reviews only the subject of parenchymal brain metastases from systemic solid tumors arising in childhood.
KeywordsLymphoma Leukemia Oncol Sarcoma Osteogenic Sarcoma
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