Central nervous system (CNS) metastases from systemic cancer are usually separated into two distinct anatomic categories depending on whether they arise in the extradural or intradural spaces. The biology of metastasis differs for each of these locations, and each cancer has its own pattern of spread. Extradural or epidural metastases usually arise from a metastasis involving bone adjacent to a neural structure or from venous plexuses or lymph channels in the extradural space (figure 20-1). Intradural metastases may involve the leptomeninges, brain, or spinal cord, and are usually of hematogenous origin. This chapter reviews only the subject of parenchymal brain metastases from systemic solid tumors arising in childhood.
KeywordsOsteogenic Sarcoma Brain Metastasis Pulmonary Metastasis Central Nervous System Disease Systemic Cancer
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- 2.Posner JP: Brain metastases: A clinician’s view of brain metastases. In Weiss LW, Gilbert HA, Posner JP (eds), Brain metastases. Boston: G.K. Hall and Co., 1980, pp 189–207.Google Scholar
- 3.Posner JP, Chernick NL, Intracranial metastases from systemic cancer. Adv Neurol 19:575–587, 1978.Google Scholar
- 8.Bross ID: The role of brain metastases in cascade processes: Implications for research and clinical management. In Weiss LW, Gilbert HA, Posner JP (eds), Brain Metastases. Boston: G.K. Hall and Co., 1980, pp 66–80.Google Scholar
- 16.Conte PF, Guerrasio A, Bumma C, Giaccane C, Musella R, Lombard G, Distefano F, Calciati A: VM 26, Adriamycine, and CCNU combination chemotherapy in metastatic brain tumors. In Hildebrand J, Gongji D, Treatment of Neoplastic Lesions of the Nervous System. Oxford: Pergamon Press, 1982, pp 161–164.Google Scholar