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Carcinomas of the Head and Neck pp 95–113Cite as

Photodynamic Therapy in the Management of Head and Neck Cancer

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 52))

Abstract

Photodynamic therapy (PDT) is a relatively new therapeutic modality utilizing a photosensitizing drug, which selectively localizes in tumors and on activation by exposure to light, results in necrosis of the tumor. Like all new therapies directed to cancer, this modality has generated great enthusiasm and initially was heralded as the panacea for this most dreaded of all diseases. Time and experience have tempered this sentiment. However, it does appear to be effective in many situations, although much basic research is required before its exact role in contemporary cancer therapy can be defined. There are two ingredients necessary for this technology to be effective—the photosensitizer and the activating light.

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References

  1. Rall DD, Loo TL, Lane M, et al.: Appearance and persistance of flourescent material in tumor tissue after tetracylcine administration. J Natl Cancer Inst 19:79–86, 1957.

    PubMed  CAS  Google Scholar 

  2. Mellors RC, Glassman A, Papanicolaou GN: A microflourimetric scanning method for the detection of cancer cells in smears of exofoliated cells. Cancer 5:458–468, 1952.

    Article  PubMed  CAS  Google Scholar 

  3. Tomson SH, Emmett EA, Fox SH: Photodestruction of mouse epithelial tumors after acridine orange and argon laser. Cancer Research 34:3124–3127, 1974.

    PubMed  CAS  Google Scholar 

  4. Castro DJ, Saxton ER, Fetterman H, et al.: Phototherapy with argon lasers and rhodamine-123 for tumor eradication. Otol Head and Neck Surg 98:581–588, 1988.

    CAS  Google Scholar 

  5. Moore GE: Diagnosis and localization of brain tumors; a clinical and experimental study employing floursecent and radioactive tracer methods. Springfield, Ill: Charles C Thomas, 1953.

    Google Scholar 

  6. Auler H, Banzer G: Untersuchungen uber die rolle der prophone beigeschwulstkranken menschen und tieren. Z Krebsforsch 53:65–68, 1942.

    Article  CAS  Google Scholar 

  7. Figge FHJ, Weiland GS, Manganiello LOJ: Cancer detection and therapy. Affinity of neoplastic embryonic and traumatized regenerating tissues for porphyrins and metalloporphyrins. Proc Soc Exptl Biol Med, 68:640–641, 1948.

    CAS  Google Scholar 

  8. Raab O: Uber die Wirkung floureszirenden stoffe auf in fusoria. A Biol 39:524–527, 1900.

    CAS  Google Scholar 

  9. Tappenier H, Jesionek A: Theropeutische reosuche met floureszierenden stoff. Muench Med Wochsder 1:2042–2044, 1903.

    Google Scholar 

  10. Policard A: Etudes sue les aspects offerts par des tumeur experimentais examinee a la lumiere de woods. Cr Soc Biol 91:1423–1425, 1924.

    Google Scholar 

  11. Rasmussen-Texdall DS, Ward GE, Figge FH: Flourescence of human lymphatic and cancer tissue following high doses of intravenous hematoporphyrin. Cancer 8:78–81, 1955.

    Article  Google Scholar 

  12. Lipson RL: The photodynamic and flourescent properties of a particular hematoporphyrin derivative and its use in tumor detection (master’s thesis). University of Minnesota, 1960.

    Google Scholar 

  13. Lipson RL, Baldes EJ, Olsen AM: Hematoporphyrin derivative: a new aid to endoscopic detection of malignant disease. J Thor Cardiovasc Surg 42:623–629, 1961.

    CAS  Google Scholar 

  14. Lipson RL, Baldes EJ, Olsen AM: A further evaluation of the use of hematoporphyrin derivative as a new aid for the endoscopic detection of malignant disease. Dis Chest 46:676–679, 1964.

    Article  PubMed  CAS  Google Scholar 

  15. Lipson RL, Gray MJ, Baldes EJ: Hematoporphyrin derivative for detection and management of cancer. Proc 9th Internat Cancer Congr, p 398, 1966.

    Google Scholar 

  16. Dougherty TJ, Grindey GB, Fiel R, et al.: Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light. J Natl Cancer Inst 55:115–119, 1975.

    PubMed  CAS  Google Scholar 

  17. Dougherty TJ: Activated dyes as anti-tumor agents. J Natl Cancer Inst 52:1333–1336, 1974.

    PubMed  CAS  Google Scholar 

  18. Diamond I, Granelli S, McDonaugh AF, et al.: Photodynamic therapy of malignant tumors. Lancet 2:1175–1177, 1973.

    Google Scholar 

  19. Moan J, Evensen JF, Christensen T, et al.: Chemical composition of hematoporphyrin derivative: tumor localizing and photosensitizing properties of its main components. Abstracts of the 10th Annual Meeting of the American Society of Photobiology, pp 173–174, Vancouver, British Columbia, Canada, 1982.

    Google Scholar 

  20. Moan J, Christensen R, Sommer S: The main photosensitizing components of hematoporphyrin derivative. Cancer Lett 15:161–166, 1982.

    Article  PubMed  CAS  Google Scholar 

  21. Kessel D: Components of hematoporphyrin derivatives and their tumor-localizing capacity. Cancer Res 42:1703–1706, 1982.

    PubMed  CAS  Google Scholar 

  22. Berenbaum M, Bonnet R, Scoundes PA: In vivo biological activity of the components of hematoporphyrin derivative. Br J Cancer 45:571–581, 1982.

    Article  PubMed  CAS  Google Scholar 

  23. Kessel D: Components of hematoporphyrin derivatives and their tumor-localizing capacity. Cancer Res 42:1703–1706, 1982.

    PubMed  CAS  Google Scholar 

  24. Dougherty TJ, Potter WR, Weishaupt KR: The structure of the active component of hematoporphyrin derivative. Porphyrins in Tumor Phototherapy, New York: Plenum, 1984.

    Google Scholar 

  25. Lipson RL, Pratt JH, Baldes EJ, et al.: Hematoporphyrin derivative for the detection of cervical cancer. Obstet Gynecol, 24:78–84, 1964.

    PubMed  CAS  Google Scholar 

  26. McCaughan JS, Guy JT, Hawley P, et al.: Hematoporphyrin derivative and photoradiation therapy of malignant tumors. Lasers in Surg and Med, 3:199–209, 1983.

    Article  Google Scholar 

  27. Doiron DR, Svaasand LO, Profio AE: Light dosimetry in tissue: application to photoradiation therapy. In: Porphyrin Photosensitization, vol 160; Kessel D and Dougherty TJ (eds). New York: Plenum, 1983.

    Google Scholar 

  28. Gregorie HB, Horger EO, Ward JL, Green JF, et al.: Hematoporphyrin derivative flourescence in malignant neoplasms. Ann Surg 167:820–827, 1968.

    Article  PubMed  Google Scholar 

  29. Winkelman J, Rasmussen-Taxdal DS: Quantitative determination of porphyrin uptake by tumor tissue following parenteral administration. Bull Johns Hopkins Hosp, 107:228–233, 1960.

    PubMed  CAS  Google Scholar 

  30. Gomer CJ, Dougherty TJ: Determination of (3H) and (14C) hematoporphyrin derivative distribution in malignant and normal tissue. Cancer Res 39:146–151, 1979.

    PubMed  CAS  Google Scholar 

  31. Bugelski PJ, Porter CW, Dougherty TJ: Autoradiographic distribution of hematoporphyrin derivative in normal and tumor tissue of the mouse. Cancer Res 41:4606–4612, 1981.

    PubMed  CAS  Google Scholar 

  32. Johnson LV, Walsh ML, Chen LB: Localization of mitochondria in living cells with rhodamine-123. Proc Natl Acad Sci USA 77:990–994, 1980.

    Article  PubMed  CAS  Google Scholar 

  33. Summerhayes IC, Lampidis TJ, Bernal SD, et al.: Unusual retention of rhodamine-123 by mitochondria in muscle and carcinoma cells. Proc Natl Acad Sci USA, 79:5292–5296, 1982.

    Article  PubMed  CAS  Google Scholar 

  34. Bernal SC, Lampidis TJ, McIsaac RM: Anticarcinoma activity in vitro of rhodamine-123, a mitochondrial-specific dye. Science 222:169–172, 1983.

    Article  PubMed  CAS  Google Scholar 

  35. Castro DJ, Saxton RE, Fetterman HR, et al.: Rhodamine-123 as a new photochemosensitizing agent with the argon laser: ‘Non-thermal’ and thermal effects on human squamous carcinoma cells in vitro. Laryngoscope 97:554–561, 1987.

    PubMed  CAS  Google Scholar 

  36. Marchesini R, Melloni E, Dasdia T, et al.: Photosensitizing properties of rhodamine-123 on different human tumor cell lines. Laser Surg Med 6(2): 163, 1986.

    Google Scholar 

  37. Van Lier JE, Brasseur N, Ali H, et al.: Sulfonated metallo phthalocyanines: new agents for photodynamic therapy. Lasers Surg Med 6:230–231, 1986 (abstract).

    Google Scholar 

  38. Straight RC, Spikes JD, et al.: Phthalocyanine dyes as photodynamic sensitizers in vivo: localization, retention and phototoxicity in a mouse tumor model. Photochem Photobiol, 43(suppl):63S, 1986 (abstract).

    Google Scholar 

  39. Sacchini V, Melloni E, Marchesini R, et al.: Topical administration of tetrasodium-mesotetraphenyl-porphinesulfonate (TPPS) and red light irradiation for the treatment of superficial neoplastic lesions. Tumori 73:19–23, 1987.

    PubMed  CAS  Google Scholar 

  40. Jori G, Reddi E, Romandini P, et al.: Studies of the possible utilization of tetra-(4-sulfonatophenyl) porphine in the photodynamic therapy of tumors. Lasers Surg Med 6:231, 1986 (abstract).

    Google Scholar 

  41. Oseroff AR, Ohuoha D, Ara G, et al.: Selective photochemotherapy of melanoma and human squamous cell carcinoma using cationic photosensitizers. J Invest Dermatol, 88:510, 1987 (abstract).

    Google Scholar 

  42. Kessel D, Thompson P: Photosensitization of leukemia L1210 cells with diaziquone. Cancer Res 46:5587–5588, 1986.

    PubMed  CAS  Google Scholar 

  43. Wang MX, Huo LM, Yang HC, et al.: An experimental study of the photodynamic activity of berberine in vitro of cancer cells. J Tradit Chin Med 6:125–127, 1986.

    PubMed  CAS  Google Scholar 

  44. Oseroff AR, Ohuoha D, Ara G, et al.: Intramitochondrial dyes allow selective in vitro photolysis of carcinoma cells. Proc Natl Acad Sci USA 83:9729–9733, 1986.

    Article  PubMed  CAS  Google Scholar 

  45. Cheng LS, Wang JZ: Photodamage in human erythrocyte membranes, induced by new photosensitizer hypocrellin A. Shin Yen Sheng Wu Hsueh Pao 18:89–97, 1985.

    CAS  Google Scholar 

  46. Firey PA, Rodgers MAJ: Photo-properties of a silicon naphthalocyanine: a potential photosensitizer for photodynamic therapy. Photochem Photobiol 45:535–538, 1987.

    Article  PubMed  CAS  Google Scholar 

  47. Aramendia PF, Redmond RW, Nonell S, et al.: The photophysical properties of porphycenes: potential photodynamic therapy agents. Photochem Photobiol 44:555–559, 1986.

    Article  PubMed  CAS  Google Scholar 

  48. Bellnier DA, Lin LW, Parrish JA: Hematoporphyrin derivative and pulse laser photoradiation, prophyrin localization and treatment of tumors. New York: Alan R Liss, pp 533–540, 1984.

    Google Scholar 

  49. Weishaupt KR, Gomer CJ, Dougherty TJ: Identification of singlet oxygen as the cytotoxic agent in photoactivation of a murine tumor. Cancer Res 36:2326–2329, 1976.

    PubMed  CAS  Google Scholar 

  50. Grossweiner LI, Goyal GG, Richard P: Effects of aggregation and sensitizer binding on liposome membrane photosensitization by hematoporphyrin and hematoporphyrin derivative. (Abstracts) Am Soc Photobiol, p 91, 1982.

    Google Scholar 

  51. Waldow SM, Henderson BW, Dougherty TJ: Potentiation of phototherapy by heat. Lasers in Surg and Med 5:83–99, 1985.

    Article  CAS  Google Scholar 

  52. Benson RC: The Use of hematoporphyrin derivative (HPD) in the localization and treatment of transitional cell carcinoma of the bladder: Porphyrin Localization and Treatment of Tumors. New York: Alan R Liss, pp 795–804, 1984.

    Google Scholar 

  53. Forbes I, Cowled A, Leong AS-Y, et al.: Phototherapy of human tumors using hematoporphyrin derivative. Med J Aust 2:489–493, 1980.

    PubMed  CAS  Google Scholar 

  54. Kennedy J: HPD photoradiation therapy for cancer at Kingston and Hamilton: porphyrin photosensitization. Kessel D, Dougherty TJ (eds) New York/London: Plenum, 1983.

    Google Scholar 

  55. Tokuda Y: Primary skin cancer, lasers and hematoporphyrin derivative in cancer Hayata Y, Dougherty TJ, Igaku-Sloin, (eds) (Tokyo/New York): pp 88, 1983.

    Google Scholar 

  56. Wile AG, Dahlman A, Burns RG: Laser photoradiation therapy of cancer following hematoporphyrin sensitization. Lasers in Surg Med 2:163–168, 1982.

    Article  CAS  Google Scholar 

  57. Tomio L, Calzavara F, Zorat PL, et al.: Photoradiation therapy for cutaneous and subcutaneous malignant tumors using hematoporphyrin: porphyrin localization and treatment of tumors. New York: Alan R Liss, pp 829–840, 1984.

    Google Scholar 

  58. Hayata Y, Kato H, Konaka, et al.: Fiberoptic bronchoscopic laser photoradiation for tumor localization in lung cancer. Chest 82:10–14, 1982.

    Article  PubMed  CAS  Google Scholar 

  59. Hayata Y, Kato H, Hememiya R, et al.: Indications for photoradiation therapy in early stage lung cancer on the basis of post-PRT histological findings: porphyrin localization and treatment of tumors. New York: Alan R Liss, pp 747–758, 1984.

    Google Scholar 

  60. Balchum O, Doiron DR, Huth G: HPD photodynamic therapy for obstructing lung cancer: porphyrin localization and treatment of tumors. New York: Alan R Liss, pp 727–745, 1984.

    Google Scholar 

  61. Aida M, Hirashima T: Cancer of the esophagus: lasers and hematoporphyrin derivative in cancer Hayata Y, Dougherty TJ (eds). Tokyo/New York: Igaku-Shoin, pp 57–64, 1983

    Google Scholar 

  62. Aida M, Kawaguchi M: Gastric cancer, lasers and hematoporphyrin derivative in cancer; Hayata Y, Dougherty TJ (eds). Tokyo/New York: Igaku-Shoin, pp 65–69, 1983.

    Google Scholar 

  63. McCaughan JS: Photoradiation of malignant tumors presensitized with hematoporphyrin derivative. In: Porphyrin Localization and Treatment of Tumors. New York: Alan R Liss, pp 805–827, 1984.

    Google Scholar 

  64. Hiazumi H, Misaki T, Miyoshi N: Photodynamic therapy of bladder tumors, lasers and hematoporphyrin derivative in cancer Y Hayata, TJ Dougherty (eds.) Tokyo/New York: Igaku-Sloin, pp 85–87, 1983.

    Google Scholar 

  65. Ward BG, Forbes IJ, Wowled PA, et al.: The treatment of vaginal recurrences of gynecologic malignancy with phototherapy following hematoporphyrin derivative treatment. Am J Obstet Gynecol 142:(3)356–357, 1982.

    PubMed  CAS  Google Scholar 

  66. Soma H, Akiya K, Nutahara S, et al.: Treatment of vaginal carcinoma with laser photo-radiation following administration of hematoporphyrin derivative. Report of a Case. Ann Chirvrgiae Gynaecologiae 71:133–136, 1982.

    CAS  Google Scholar 

  67. Rettenmaier M, Berman M, DiSaia P, et al.: Photoradiation therapy in gynecology. Porphyrin Localization and Treatment of Tumors. DR Doiron (ed) New York: Alan R Liss, 1984.

    Google Scholar 

  68. McCulloch GA, Forbes IJ, Lee See K, et al.: Phototherapy in malignant brain tumors. Porphyrin Localization and Treatment of Tumors. New York: Alan R Liss, pp 709–717, 1984.

    Google Scholar 

  69. Bruce RA: Photoradiation of choroidal malignant melanoma. Porphyrin localization and treatment of tumors. New York: Alan R Liss, pp 777–784, 1984.

    Google Scholar 

  70. Dahlman A, Wile AG, Burns RG, et al.: Laser photoradiation therapy of cancer. Cancer Research 43:430–434, 1983.

    PubMed  CAS  Google Scholar 

  71. Schuller DE, McCaughn JS, Rock RP: Photoradiation in head and neck cancer. Arch Otolaryngol 3:351–355, 1985.

    Google Scholar 

  72. Wile AG, Novotny J, Mason GR: Photoradiation therapy of head and neck cancer. Am J Clin Oncol 6:39–63, 1984.

    Article  Google Scholar 

  73. Keller GS, Doiron DJ: Photodynamic therapy in otolaryngology/head and neck surgery. Presented at the course on PDT at Western Institute for Laser Treatment, Oct 1984.

    Google Scholar 

  74. Gluckman JL, Waner M, Shumrick K, et al.: Photodynamic therapy. A viable alternative to conventional therapy for early lesions of the upper aerodigestive tract. Arch Otol Head and Neck Surg 112:949–952, 1986.

    CAS  Google Scholar 

  75. Gluckman JL, Weissler MC: Role of photodynamic therapy in the management of early cancers of the upper aerodigestive tract. Laser in Med Science 1:217–219, 1986.

    Article  Google Scholar 

  76. Gluckman JL, Crissman JD, Donegan JO: Multicentric squamous cell carcinoma of the upper aerodigestive tract. Head and Neck Surg, pp 90–96, 1980.

    Google Scholar 

  77. Gluckman JL, Crissman JD: Survival rates in 548 patients with multiple primary neoplasms of the upper aerodigestive tract. Laryngoscope 93:(1)71–74, (Jan.) 1983.

    Article  PubMed  CAS  Google Scholar 

  78. Gluckman JL: Synchronous multiple primaries of the upper aero-digestive system. Arch of Otolaryngology 105:597–598, 1979.

    CAS  Google Scholar 

  79. Profio EA, Doiron DR: A feasibility study for the use of fluorescence bronchoscopy for localization of small lung tumors. Phys Med Biol 22(5):949–957, 1977.

    Article  PubMed  CAS  Google Scholar 

  80. Doiron DR, Profio E, Vincent RG, et al.: Fluorescence bronchoscopy for the detection of lung cancer. Chest 76:(1)27–32, 1979.

    Article  PubMed  CAS  Google Scholar 

  81. Kinsey TH, Cortese DA, Sanderson DR: Detection of hematoporphyrin fluorescence during fiberoptic endoscopy to localize early bronchogenic carcinoma. Mayo Clin Proc 53:594, 1978.

    PubMed  CAS  Google Scholar 

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Authors
  1. Jack L. Gluckman
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  2. Robert P. Zitsch
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Editors and Affiliations

  1. Division of Medical Oncology—M211, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA

    Charlotte Jacobs M.D.

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© 1990 Kluwer Academic Publishers, Boston

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Gluckman, J.L., Zitsch, R.P. (1990). Photodynamic Therapy in the Management of Head and Neck Cancer. In: Jacobs, C. (eds) Carcinomas of the Head and Neck. Cancer Treatment and Research, vol 52. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1499-8_7

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  • DOI: https://doi.org/10.1007/978-1-4613-1499-8_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8806-0

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