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Antibody targeting: Theoretical considerations

  • Arthur Bradwell
  • Peter Dykes
  • Gillian Thomas
Part of the Cancer Treatment and Research book series (CTAR, volume 51)

Abstract

The detection of tumors using radiolabeled antibodies has been usefully applied to many tumor types [1]. Many important factors can be defined and thereby developed into mathematical models to assess the potential and limitations of the technique. This allows a clear understanding of the physical and biologic problems that need to be solved. At present fairly superficial lesions, between 1/2 and 1 cm in diameter, are likely to be detected with an optimal combination of attainable factors. Theoretically, for the majority of tumors, the technique is not significantly more sensitive than several other imaging methods.

Keywords

Count Rate Uptake Ratio Tumor Imaging Count Density Antibody Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Arthur Bradwell
  • Peter Dykes
  • Gillian Thomas

There are no affiliations available

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