T-cell depletion for bone marrow transplantation: Effects on graft rejection, graft-versus-host disease, graft-versus-leukemia, and survival

  • Richard E. Champlin
Part of the Cancer Treatment and Research book series (CTAR, volume 50)


Graft-versus-host disease (GVHD) remains the major problem to be overcome in allogeneic bone marrow transplantation [1–3]. Despite posttransplant immunosuppressive therapy with cyclosporine or methotrexate, moderate to severe acute GVHD develops in approximately 45% of transplant recipients with an HLA-identical sibling donor [4] and in >75% of patients from HLA-nonidentical relatives [5]. Recently, bone marrow transplants have been performed from unrelated HLA-identical or partially matched related donors [6–10]. Preliminary results indicate that even with phenotypically identical unrelated donor-recipient pairs and the use of combination posttransplant immunosuppressive therapy, the incidence of acute GVHD exceeds 75%.


Bone Marrow Transplantation Graft Failure Acute GVHD Allogeneic Bone Marrow Transplantation Donor Bone Marrow 
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© Kluwer Academic Publishers 1990

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  • Richard E. Champlin

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