Laser Balloon Angioplasty: Experimental In-Vivo and In-Vitro Studies

  • J. Richard Spears
  • I. Nigel Sinclair
  • Ronald D. Jenkins
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 103)


Important causes of suboptimal angiographic results following percutaneous transluminal coronary angioplasty (PTCA) include elastic recoil, arterial dissection, and the presence of thrombus. Although increased vasomotor tone may contribute to a reduction of luminal diameter improvement, passive recoil probably accounts for most of the latter. Typically, in most clinical series [1–4] a mean residual diameter of acute stenosis of approximately 30%, which roughly corresponds to a 50% luminal cross-sectional area stenosis, is found after successful PTCA, presumably as a result of such recoil. Intimal tears may further compromise an apparently successful PTCA procedure, even without propagation of a dissection, by local disruption of laminar flow patterns. When thrombus is associated with a lesion treated with PTCA, a poor result is frequently encountered, perhaps as a result of the difficulty in attempting to remodel this tissue with pressure and the possibility that spreading the thrombus along the luminal surface may increase the number of sites of potential propagation of the thrombus.


Arterial Wall Balloon Angioplasty Luminal Diameter Tissue Temperature Laser Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • J. Richard Spears
  • I. Nigel Sinclair
  • Ronald D. Jenkins

There are no affiliations available

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