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Molecular mechanisms involved in insulin action

  • Chapter
Understanding Insulin Action

Part of the book series: Ellis Horwood Series in Biochemistry and Biotechnology ((EMISS))

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Abstract

Many of the metabolic effects of insulin were shown in the previous chapter to be mediated via alterations in the phosphorylation state of the regulatory enzymes involved. In the majority of cases the effect of insulin is to cause the dephosphorylation of target enzymes. Thus, for instance, the key regulatory enzymes of glycogen synthesis (glycogen synthase), glucose oxidation (pyruvate dehydrogenase), lipolysis (hormone-sensitive lipase) are all dephosphorylated in response to insulin. It follows that dephosphorylation of regulatory enzymes is a central mechanism of insulin action.

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References

  • Alexander, M. & Goodman, H. M. (1986) In Mechanisms of insulin action, Belfrage, P., Donner, J. & Stralford, P. (Eds), Elsevier, Amsterdam, pp. 395–405.

    Google Scholar 

  • Avruch, J., Witters, L. A., Alexander, M. C. & Bush, M. A. (1978) J. Biol. Chem. 253, 4754–4761.

    PubMed  CAS  Google Scholar 

  • Avruch, J., Nemenoff, R. A., Pierce, M., Kwok, Y. C. & Blackshear, P. (1985) In Molecular basis of insulin action, Czech, M. P. (Ed.), Plenum Press, New York, pp. 263–297.

    Chapter  Google Scholar 

  • Beale, E., Katzen, C. & Granner, D. K. (1981) Biochemistry 20, 4878–4883.

    Article  PubMed  CAS  Google Scholar 

  • Beale, E., Andreone, T., Koch, S., Granner, M. & Granner, D. K. (1985) Diabetes 33, 328–332.

    Article  Google Scholar 

  • Belsham, G. J., Brownsey, R. W. & Denton, R. M. (1982) Biochem. J. 204, 345–352.

    PubMed  CAS  Google Scholar 

  • Birnbaum, M. J., Haspel, H. C. & Rosen, O. M. (1986) Proc. Natl. Acad. Sci. USA 83, 5784–5788.

    Article  PubMed  CAS  Google Scholar 

  • Blackshear, P., Nemenoff, R. A. & Avruch, J. (1983) Biochem. J. 214, 11–19.

    PubMed  CAS  Google Scholar 

  • Blackshear, P., Witters, L. A., Girard, P. R., Kuo, J. F. & Quamo, S. N. (1985) J. Biol. Chem. 260, 13304–13315.

    PubMed  CAS  Google Scholar 

  • Brownsey, R. W., Hughes, W. A., Denton, R. M. & Mayer, R. J. (1977) Biochem. J. 168, 441–445.

    PubMed  CAS  Google Scholar 

  • Brownsey, R. W. & Denton, R. M. (1982) Biochem. J. 202, 77–86.

    PubMed  CAS  Google Scholar 

  • Cohen, P. (1985) Eur. J. Biochem. 151, 439–448.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, P. (1986) In The enzymes, Vol. 18, Krebs, E. G. & Boyer, P. D. (Eds), Academic Press, New York.

    Google Scholar 

  • Corvera, S. & Czech, M. P. (1985) Proc. Natl. Acad. Sci. USA 82, 7314–7318.

    Article  PubMed  CAS  Google Scholar 

  • Corvera, S., Davis, R. J., Roach, P. J., DePaoli-Roach, A. & Czech, M. P. (1986) Ann. N.Y. Acad. Sci. 488, 419–428.

    Article  PubMed  CAS  Google Scholar 

  • Cushman, S. W. & Wardzala, L. J. (1980) J. Biol. Chem. 255, 4758–4762.

    PubMed  CAS  Google Scholar 

  • Damuni, Z., Humphreys, J. S. & Reed, L. J. (1984) Biochem. Biophys. Res. Comm. 124, 95–99.

    Article  PubMed  CAS  Google Scholar 

  • Denton, R. M., Coore, H. G., Martin, B. R. & Randle, P. J. (1971) Nature 231, 113–116.

    Google Scholar 

  • Denton, R. M., Brownsey, R. W. & Belsham, G. J. (1981) Diabetologia 21, 347–363.

    Article  PubMed  CAS  Google Scholar 

  • Denton, R. M., McCormack, J. G. & Marshall, S. E. (1984) Biochem. J. 217, 441–452.

    PubMed  CAS  Google Scholar 

  • DePaoli-Roach, A. A., Ahmad, Z. & Roach, P. J. (1981) J. Biol. Chem. 256, 8955–8962.

    PubMed  CAS  Google Scholar 

  • Erikson, E. & Maller, J. L. (1985) Proc. Natl. Acad. Sci. USA 82, 742–746.

    Article  PubMed  CAS  Google Scholar 

  • Erikson, E. & Maller, J. L. (1986) J. Biol. Chem. 261, 350–355.

    PubMed  CAS  Google Scholar 

  • Erikson, E., Stefanovic, D., Blenis, J., Erikson, R. L. & Maller, J. (1987) Mol. Cell. Biol. 7, 3147–3155.

    PubMed  CAS  Google Scholar 

  • Gibbs, E. M., Allard, W. J. & Lienhard, G. E. (1986) J. Biol. Chem. 261, 16597–16604.

    PubMed  CAS  Google Scholar 

  • Granner, D. K., Sasaki, K., Chu, D., Koch, S., Cripe, T. & Peterson, D. (1986) In Mechanisms of insulin action, Belfrage, P., Donner, J. & Stralfors, P. (Eds), Elsevier, Amsterdam, pp. 365–382.

    Google Scholar 

  • Haystead, T. A. J. & Hardie, D. G. (1986) Biochem. J. 240, 99–106.

    PubMed  CAS  Google Scholar 

  • Holland, R. & Hardie, D. G. (1985) FEBS Lett. 181, 308–312.

    Article  PubMed  CAS  Google Scholar 

  • Holland, R., Hardie, D. G., Glegg, R. A. & Zammit, V. A. (1985) Biochem. J. 226, 139–149.

    PubMed  CAS  Google Scholar 

  • Houston, B. & Nimmo, H. G. (1985) Biochim. Biophys. Acta 844, 233–239.

    Article  PubMed  CAS  Google Scholar 

  • James, D. E., Brown, R., Navarro, J. & Pilch, P. F. (1988) Nature 333, 183–185.

    Article  PubMed  CAS  Google Scholar 

  • Jones, S. W., Erikson, E., Blenis, J., Maller, J. L. & Erikson, R. L. (1988) Proc. Natl. Acad. Sci. USA 85, 3377–3381.

    Article  PubMed  CAS  Google Scholar 

  • Kitagawa, K., Nishino, H. & Iwashima, A. (1985) Biochem. Biophys. Res. Commun. 128, 1303–1309.

    Article  PubMed  CAS  Google Scholar 

  • Kono, T. (1985) In Molecular basis of insulin action, Czech, M. P. (Ed.), Plenum Press, New York, pp. 423–433.

    Chapter  Google Scholar 

  • Kono, T., Suzuki, K., Dansey, L. E., Robinson, F. W. & Blevins, T. L. (1981) J. Biol. Chem. 256, 6400–6407.

    PubMed  CAS  Google Scholar 

  • Krebs, E. G. & Beavo, J. A. (1979) Ann. Rev. Biochem. 48, 923–959.

    Article  PubMed  CAS  Google Scholar 

  • Lawrence, J. C., Hiken, J. F., DePaoli-Roach, A. A. & Roach, P. J. (1983) J. Biol. Chem. 258, 10710–10719.

    PubMed  CAS  Google Scholar 

  • LeCam, A. (1982) J. Biol. Chem. 257, 8376–8385.

    CAS  Google Scholar 

  • Maller, J. L. (1987) J. Cyclic Nucl. Prot. Phos. Res. 11, 543–555.

    CAS  Google Scholar 

  • Marchington, D. R., Kerbey, A. L., Jones, A. E. & Rändle, P. J. (1987) Biochem. J. 246, 233–236.

    PubMed  CAS  Google Scholar 

  • Martin, B. R., Denton, R. M., Pask, H. & Rändle, P. J. (1972) Biochem. J. 129, 763–773.

    PubMed  CAS  Google Scholar 

  • Martin-Perez, J. & Thomas, G. (1983) Proc. Natl. Acad. Sci. USA 80, 926–930.

    Article  PubMed  CAS  Google Scholar 

  • Martin-Perez, J., Siegmann, M. & Thomas, G. (1984) Cell 36, 287–294.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, S. E., McCormack, J. G. & Denton, R. M. (1984) Biochem. J. 218, 249–260.

    PubMed  CAS  Google Scholar 

  • Mueckler, M., Caruso, C., Baldwin, S. A., Panico, M., Blench, I., Morris, H. R., Allard, W. J., Lienhard, G. E. & Lodish, h. F. (1985) Science, 229, 941–945.

    Article  PubMed  CAS  Google Scholar 

  • Ohlen, J., Siess, E. A., Loffler, G. & Wieland, O. H. (1978) Diabetologia 14, 135–139.

    Article  PubMed  CAS  Google Scholar 

  • Oka, Y., Mottola, C., Oppenheimer, C. L. & Czech, M. P. (1984) Proc. Natl. Acad. Sci. USA 81, 4028–4032.

    Article  PubMed  CAS  Google Scholar 

  • Parker, P. J., Caudwell, F. B. & Cohen, P. (1983) Eur. J. Biochem. 130, 227–234.

    Article  PubMed  CAS  Google Scholar 

  • Parker, P. J., Katan, M., Waterfield, M. D. & Leader, D. P. (1985) Eur. J. Biochem. 148, 579–586.

    Article  PubMed  CAS  Google Scholar 

  • Pierce, M. W., Palmer, J. L., Keutmann, H. T. & Avruch, J. (1981) J. Biol. Chem. 256, 8867–8870.

    PubMed  CAS  Google Scholar 

  • Pierce, M. W., Palmer, J. L., Keutmann, H. T., Hall, T. A. and Avruch, J. (1982) J. Biol. Chem. 257, 10681–10686.

    PubMed  CAS  Google Scholar 

  • Randle, P. J. (1986) Biochem. Soc. Trans. 14, 799–806.

    PubMed  CAS  Google Scholar 

  • Randle, P. J., Kerbey, A. L. & Espinal, J. (1988) Diab. Metab. Rev. 4, 623–638.

    Article  CAS  Google Scholar 

  • Reed, L. J. & Yeaman, S. J. (1987) In The enzymes, Vol. 18, Part B, Boyer, P. D. & Krebs, E.G. (Eds), Academic Press, New York, pp. 77–95.

    Google Scholar 

  • Simpson, I. A. & Cushman, S. W. (1985) In Molecular basis of insulin action, Czech, M. P. (Ed.), Plenum Press, New York, pp. 399–422.

    Chapter  Google Scholar 

  • Simpson, I. A. & Cushman, S. W. (1986) Ann. Rev. Biochem. 55, 1059–1089.

    Article  PubMed  CAS  Google Scholar 

  • Smith, C. J., Wejksnora, P. J., Warner, J. R., Rubin, C. S. & Rosen, O. M. (1979) Proc. Natl. Acad. Sci. USA 76, 2725–2729.

    Article  PubMed  CAS  Google Scholar 

  • Stepp, L. R., Pettit, F. H., Yeaman, S. J. & Reed, L. J. (1983) J. Biol. Chem. 258, 9454–9458.

    PubMed  CAS  Google Scholar 

  • Sturgill, T. W., Ray, L. B., Erikson, E. & Maller, J. L. (1988) Nature 334, 715–718.

    Article  PubMed  CAS  Google Scholar 

  • Suzuki, K. & Kono, T. (1980) Proc. Natl. Acad. Sci. USA 77, 2542–2545.

    Article  PubMed  CAS  Google Scholar 

  • Tanner, L. & Lienhard, G. L. (1987) J. Biol. Chem. 262, 8975–8980.

    PubMed  CAS  Google Scholar 

  • Thomas, A. P. & Denton, R. M. (1986) Biochem. J.

    Google Scholar 

  • Thomas, A. P., Diggle, T. A. & Denton, R. M. (1986) Biochem. J.

    Google Scholar 

  • Thomas, G., Siegmann, M., Kubler, A. M., Gordon, J. & Jimenez de Asua, L. (1980) Cell 19, 1015–1023.

    Article  PubMed  CAS  Google Scholar 

  • Thomas, G., Martin-Perez, J., Siegmann, M. & Otto, A. (1982) Cell 30, 235–242.

    Article  PubMed  CAS  Google Scholar 

  • Thorens, B., Sarker, H. K., Kaback, H. R. & Lodish, H. F. (1988) Cell 55, 281–290.

    Article  PubMed  CAS  Google Scholar 

  • Traugh, J. A. (1981) In Biochemical actions of hormones, Litwack, G. (Ed.), Academic Press, New York, pp. 167–208.

    Google Scholar 

  • Tung, H. Y. L., Pelech, S., Fischer, M. J., Pogson, C. I. & Cohen, P. (1985) Eur. J. Biochem. 149, 305–313.

    Article  PubMed  CAS  Google Scholar 

  • Vargas, A. M., Halestrap, A. P. & Denton, R. M. (1982) Biochem. J. 208, 221–229.

    PubMed  CAS  Google Scholar 

  • Villar-Palasi, C. & Larner J. (1960) Biochem. Biophys. Acta 39, 171–173.

    Article  PubMed  CAS  Google Scholar 

  • Ward, D. M. & Kaplan, J. (1986) Biochem. J. 238, 721–728.

    PubMed  CAS  Google Scholar 

  • Wardzala, L. J. & Jeanrenaud, B. (1981) J. Biol. Chem. 256, 7090–7093.

    PubMed  CAS  Google Scholar 

  • Wardzala, L. J. & Jeanrenaud, B. (1983) Biochem. Biophys. Acta 730, 49–56.

    Article  PubMed  CAS  Google Scholar 

  • Wardzala, L. J., Cushman, S. W. & Salans, L. B. (1978) J. Biol. Chem. 253, 8002–8005.

    PubMed  CAS  Google Scholar 

  • Wardzala, L. J., Simpson, I. A., Rechler, M. W. & Cushman, S. W. (1984) J. Biol. Chem. 259, 8378–8383.

    PubMed  CAS  Google Scholar 

  • Wettenhall, R. E. H. & Morgan, F. J. (1984) J. Biol. Chem. 259, 2084–2091.

    PubMed  CAS  Google Scholar 

  • Witters, L. A., Moriarty, D. & Martin, D. B. (1979) J. Biol. Chem. 254, 6644–6649.

    PubMed  CAS  Google Scholar 

  • Witters, L. A., Tipper, J. P. & Bacon, G. W. (1983) J. Biol. Chem. 258, 5643–5648.

    PubMed  CAS  Google Scholar 

  • Witters, L. A., Vater, C. A. & Lienhard, G. E. (1985) Nature 316, 777–778.

    Article  Google Scholar 

  • Witters, L. A., Watts, T. D., Daniels, D. L. & Evans, J. L. (1988) Proc. Natl. Acad. Sci. USA 85, 5473–5477.

    Article  PubMed  CAS  Google Scholar 

  • Woodgett, J. R. & Cohen, P. (1984) Biochim. Biophys. Acta 788, 339–347.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Endocrinology, Glaxo Research Laboratories, Research Triangle Park, North Carolina, USA

    J. Espinal B.Sc., D.Phil (Head of Diabetes Research Section)

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  1. J. Espinal B.Sc., D.Phil
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© 1989 J. Espinal/Ellis Horwood Limited

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Espinal, J. (1989). Molecular mechanisms involved in insulin action. In: Understanding Insulin Action. Ellis Horwood Series in Biochemistry and Biotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1475-2_4

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  • DOI: https://doi.org/10.1007/978-1-4613-1475-2_4

  • Publisher Name: Springer, Boston, MA

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