Distribution of Lead in Human Bone: III. Synchrotron X-Ray Microscope Measurements
Measurement of the microdistribution of lead and other elements in bone is of interest for two reasons. First, the correlation of the lead concentrations with histological features in the bone may shed light on the biological mechanisms involved in the absorption and redistribution of lead in bone structures and help identify the compartments in which the lead is stored. Second, a knowledge of the distribution is required in order to provide a firm basis for the interpretation of in vivo x-ray measurements of bone lead concentrations based on the detection of characteristic K or L x-rays.
KeywordsAtomic Ratio Lead Concentration Periosteal Surface Haversian Canal Acid Dehydratase
Unable to display preview. Download preview PDF.
- Abdulla, M., Svensson, B. S., and Haeger-Aronson, B., 1979, Antagonistic effects of zinc and aluminum on lead inhibition of δ- aminolevulinic acid dehydratase, Arch. Environ. Health., 34:463.Google Scholar
- Jones, K. W., Schidlovsky, G., Williams, F. H., Jr., Wedeen, R. P., and Batuman, V., 1987, In-vivo determination of tibial lead by K x- ray fluorescence with a 109Cd source, in: “In Vivo Body Composition Studies. Proceedings of an International Symposium,” K. J. Ellis. S. Yasumura, and U. D. Morgan. eds., Institute of Physical Sciences in Medicine, London.Google Scholar
- Rosen, J. F., Markowitz, M. F., Bijur, P. E., Jenks, S. T., Wielopolski. L., Kalef-Ezra, J. A., and Slatkin, D. H., 1989, L- line x-ray fluorescence of cortical bone lead compared with the CaNa2EDTA test in lead-toxic children: public health implications, Proc. Natl. Acad. Sci. USA, 86: 685.PubMedCrossRefGoogle Scholar
- Vaughn. J., 1981, “The Physiology of Bone,” Clarendon Press, Oxford.Google Scholar