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Bacterial Reverse Transcriptase and msDNA

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Molecular Evolution of Viruses — Past and Present

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Abstract

Retrons are a new class of genetic elements found in the chromosome of a large number of different bacteria. These elements code for a reverse transcriptase (RT) that is structurally similar to the polymerases of retroviruses. The retron associated RT is responsible for the production of an unusual extrachromosomal satellite DNA, known as multicopy, single-stranded DNA (msDNA). Synthesis of msDNA is dependent on a novel self-priming mechanism, resulting in the formation of a 2′,5′-phosphodiester bond. A comparison of bacterial RTs is presented, noting conserved and unique features of these polymerases. In addition, the origin, means of dissemination, and possible activities of these functionally obscure retroelements are discussed.

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Author notes

  1. Scott A. Rice & Bert C. Lampson

    Present address: Department of Microbiology, University of Tennessee, Knoxville, TN, 37996-0845, USA

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    Authors
    1. Scott A. Rice
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    2. Bert C. Lampson
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    Editors and Affiliations

    1. Department of Molecular Virology, The Hebrew University, Hadassah Medical School, Jerusalem, Israel

      Yechiel Becker

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    © 1996 Kluwer Academic Publishers

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    Rice, S.A., Lampson, B.C. (1996). Bacterial Reverse Transcriptase and msDNA. In: Becker, Y. (eds) Molecular Evolution of Viruses — Past and Present. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1407-3_3

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    • DOI: https://doi.org/10.1007/978-1-4613-1407-3_3

    • Publisher Name: Springer, Boston, MA

    • Print ISBN: 978-1-4612-8610-3

    • Online ISBN: 978-1-4613-1407-3

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