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Retrotransposition and Herpesvirus Evolution

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Molecular Evolution of Viruses — Past and Present

Abstract

One of the more interesting developments in herpesvirus evolution concerns the acquisition of novel, non-ubiquitous herpesvirus genes. A number of these are related to known cellular genes. How did herpesviruses acquire such genes? Our recent demonstration of retrovirus integration into herpesviruses suggests a potentially important role for retrotransposition in herpesvirus evolution and in the acquisition of novel genes, cellular in origin. Herpesvirus genome development has been characterized by a number of structural and evolutionary properties that support this proposal. We first discuss the evidence for retroviral integration into herpesviruses. The functional significance of this phenomenon is presently unclear. However, in the broader context of retrotransposition, a number of attractive features serve to explain the capture of structural and regulatory elements throughout herpesvirus evolution. These possibilities are discussed in detail.

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  1. Peter Brunovskis

    Present address: Department of Molecular Biology and Microbiology, Case-Western Reserve University, Cleveland, OH, 44106, USA

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  1. Department of Molecular Biology and Microbiology, Case-Western Reserve University, Cleveland, OH, 44106, USA

    Hsing-Jien Kung

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  1. Peter Brunovskis
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  1. Department of Molecular Virology, The Hebrew University, Hadassah Medical School, Jerusalem, Israel

    Yechiel Becker

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© 1996 Kluwer Academic Publishers

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Brunovskis, P., Kung, HJ. (1996). Retrotransposition and Herpesvirus Evolution. In: Becker, Y. (eds) Molecular Evolution of Viruses — Past and Present. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1407-3_16

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  • DOI: https://doi.org/10.1007/978-1-4613-1407-3_16

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