Abstract
The application of UOP Sorbex* simulated moving bed (SMB) technology for pharmaceutical separations is described. The marked differences between pharmaceutical and conventional bulk separations, makes predicting initial starting conditions difficult unless a well-defined modeling strategy is used. The dispersion and mass transfer coefficients of the adsorbent bed are determined using well-known correlations. Langmuir isotherms were measured using breakthrough tests. A one-dimensional, axial-dispersed plug flow, linear driving-force model for the SMB process is solved using finite differences and a Newton Raphson iterative procedure. The model results are compared with experimental results for separation of 3-chloro-l-phenyl-propanol (CPP), a drug intermediate in the manufacture of flouxetine.
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© 1996 Kluwer Academic Publishers
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Dandekar, H.W., Chandhok, A.K., Priegnitz, J.W. (1996). Modeling and Simulation of SMB Technology for Pharmaceutical and Fine Chemical Applications. In: LeVan, M.D. (eds) Fundamentals of Adsorption. The Kluwer International Series in Engineering and Computer Science, vol 356. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1375-5_29
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DOI: https://doi.org/10.1007/978-1-4613-1375-5_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8594-6
Online ISBN: 978-1-4613-1375-5
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