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Role of vascular adrenergic mechanisms in the haemodynamic and PGI2 stimulating effects of angiotensin in diabetic dogs

  • Chapter
Biochemical Regulation of Myocardium

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 19))

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Abstract

In aware of the well-known altered vascular responsiveness in the diabetic vasculature, this study aimed to compare the haemodynamic and PGI2 releasing effects of angiotensin in metabolically healthy (12) and alloxan-(560 umol/kg) diabetic (12) dogs as well as to analyze the role of vascular adrenoceptors in this. In vivo the effect of intracoronarially administered angiotensin (63–125–250–500–1000 pmol/kg/min) on coronary blood flow, mean arterial blood pressure, myocardial contractile force and heart rate was investigated without and with pretreatment of 2 umol/kg phentolamine. In vitro PGI2 release by isolated coronary rings was induced by 50 nmol/1 angiotensin before and after pretreatment with 5 umol/1 phentolamine and measured by radioimmunoassay. Angiotensin enhances dose-dependently both the mean arterial blood pressure and coronary blood flow, while it provokes a considerable (p < 0.05) increase of PGI2 formation by isolated coronary arterial rings. These alterations could be prevented by phentolamine administration both in vivo and in vitro, while this drug did not affect the angiotensin-induced enhancement of diabetic coronary blood flow. On the other hand the increase of blood pressure by angiotensin was found to be more (p < 0.05) expressed in diabetes and it could be further potentiated by phentolamine. PGI2 synthesis by isolated diabetic coronary rings could not be modified either by angiotensin alone or in combination with phentolamine. On the basis of above data, the lack of stimulated vascular PGI2 formation mediated by alpha-adrenergic mechanisms is supposed to causatively contribute to the diminished sensitivity of diabetic coronary arteries to vasodilation.

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Authors and Affiliations

  1. National Institute of Cardiology, H-1450, P.O.B. 9–88, Budapest, Hungary

    Mária Zsófia Koltai, Ildikó Pósa, Erzsébet Kocsis, Peter Rösen & Gábor Pogátsa

  2. Diabetesforschungsinstitut, Düsseldorf, Germany

    Mária Zsófia Koltai, Ildikó Pósa, Erzsébet Kocsis, Peter Rösen & Gábor Pogátsa

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  1. Mária Zsófia Koltai
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  2. Ildikó Pósa
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  3. Erzsébet Kocsis
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  4. Peter Rösen
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  5. Gábor Pogátsa
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Editors and Affiliations

  1. Max Delbrück Center for Molecular Medicine, Robert-Rossle-Strasse 10, 13122, Berlin-Buch, Germany

    Roland Vetter  & Ernst-Georg Krause  & 

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© 1996 Kluwer Academic Publishers

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Koltai, M.Z., Pósa, I., Kocsis, E., Rösen, P., Pogátsa, G. (1996). Role of vascular adrenergic mechanisms in the haemodynamic and PGI2 stimulating effects of angiotensin in diabetic dogs. In: Vetter, R., Krause, EG. (eds) Biochemical Regulation of Myocardium. Developments in Molecular and Cellular Biochemistry, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1289-5_18

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  • DOI: https://doi.org/10.1007/978-1-4613-1289-5_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8551-9

  • Online ISBN: 978-1-4613-1289-5

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