Skip to main content

Part of the book series: Developments in Oncology ((DION,volume 78))

  • 93 Accesses

Abstract

Stocks in 1957 suggested in the Annual Report of the British Empire Cancer Campaign that alcohol consumption may be a causative factor for colorectal cancer (Stocks 1957). Numerous studies followed, and at the time of writing, 93 studies in humans have examined the relationship between previous alcohol consumption, colorectal adenomas and colorectal cancer. During the last decade a few modest experimental studies have also examined the effect of alcohol on chemically induced colorectal carcinogenesis in rat models. Several hypotheses have been proposed as to how alcohol might operate to cause colorectal tumors, at both a cellular and a pathophysiologic level.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahnen DJ. Are animal models of colon cancer relevant to human disease? Dig Dis Sci 30 Dec Suppl 103S–106S, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Arbman G, Axelson O, Eriksson-Begodzki AB, et al. Cereal fibre, calcium and colorectal cancer. Cancer 69:2042–2048, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Barak AJ, Beckenhaur HC, Tuma DJ, et al. Effects of prolonged ethanol feeding on methionine metabolism in rat liver. Biochem Cell Biol 65:230–233, 1987.

    Article  PubMed  CAS  Google Scholar 

  • Barra S, Negri E, Franceschi S, et al. Alcohol and colorectal cancer: a case-control study from Northern Italy. Cancer Causes and Control 3:153–159, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Bell J, The E, Patel A, et al. The detection of at-risk drinking in a teaching hospital. Med J Aust 149:351–355, 1988.

    PubMed  CAS  Google Scholar 

  • Benito E, Cabeza E, Moreno V, et al. Diet and colorectal adenomas: a case-control study in Majorca. Int J Cancer 55:213–219, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Benito E, Obrador A, Stiggelbout A, et al. A population-based case-control study of colorectal cancer in Majorca. I. Dietary factors. Int J Cancer 45:69–75, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Berta JL, Coste T, Rautureau J, et al. Alimentation et cancers recto-colique: resultats d’une etude ‘Cas-Tenoin’. Gastroenterol Clin Biol 9:348–353, 1985.

    PubMed  CAS  Google Scholar 

  • Bidoli E, Franceschi S, Talamini R, et al. Food consumption and cancer of the colon and rectum in North-Eastern Italy. Int J Cancer 50:223–229, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Biles B, Emerson TR. Examination of fibres in beer. Nature 219:93–94, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Bingham S, Williams DDR, Cole TJ, James WPT. Dietary fibre and regional large bowel cancer mortality in Britain. Br J Cancer 40:456–463, 1979.

    Article  PubMed  CAS  Google Scholar 

  • Bjelke E. Epidemiologic studies of cancer of the stomach, colon and rectum. Scand J Gastroenterol 9 Suppl 31:1–235, 1974.

    Google Scholar 

  • Boutron MC, Faivre J. Alcohol, tobacco and the adenoma-carcinoma sequence: a case-control study in Burgundy, France. Gastroenterol 104:A390, 1993.

    Google Scholar 

  • Boutron MC, Faivre J, Dop MC et al. Tobacco, alcohol and colorectal tumors: a multistep process. Am J Epidemiol 141:1038–1046, 1995a.

    PubMed  CAS  Google Scholar 

  • Boutron MC, Senesse P, Faivre J. Folate, alcohol and the adenoma-carcinoma sequence. Gastroenteroloy 108:A450, 1995b.

    Article  Google Scholar 

  • Breslow NE, Enstrom JE. Geographic correlations between cancer mortality rates and alcohol-tobacco consumption in the United States. JNCI 53:631–639, 1974.

    PubMed  CAS  Google Scholar 

  • Bristol JB, Emmett PM, Heaton KW, et al. Sugar, fat and the risk of colorectal cancer. Br Med J 291:1567–1570, 1985.

    Article  Google Scholar 

  • Carstensen JM, Bygren LO, Hatschek T. Cancer incidence among Swedish brewery workers. Int J Cancer 45:393–396, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Centonze S, Boeing H, Leoci C, et al. Dietary habits and colorectal cancer in a low-risk area. Results from a population-based case-control study in Southern Italy. Nutr Cancer 21:233–246, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Choi SY, Kahyo H. Effect of cigarette smoking and alcohol consumption in the etiology of cancer of the digestive tract. Int J Cancer 49:381 -386, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Cope GF, Wyatt JI, Pinder IF, et al. Alcohol consumption in patients with colorectal adenomatous polyps. Gut 32:70–72, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Cummings JH, Bingham SA, Heaton KW, et al. Fecal weight, colon cancer risk and dietary intake of nonstarch polysaccharide (dietary fiber). Gastroenterology 103:1783–1789, 1992.

    PubMed  CAS  Google Scholar 

  • Dales LG, Friedman GD, Ury HK, et al. A case-control study of relationships of diet and other traits to colorectal cancer in American blacks. Am J Epidemiol 109:132–144, 1978.

    Google Scholar 

  • De Verdier MG, Hagman I, Steineck G, et al. Diet, body mass and colorectal cancer: a case-referent study in Stockholm. Int J Cancer 36:832–838, 1990.

    Article  Google Scholar 

  • Dean G, MacLennan R, McLoughlin H, et al. Causes of death of blue collar workers at a Dublin brewery 1954–73. Br J Cancer 40:581–589, 1979.

    Article  PubMed  CAS  Google Scholar 

  • Diamond M. Adenomas of the rectum and sigmoid in alcoholics: a sigmoidoscope study. Am J Dig Dis 19:47–50, 1952.

    Article  PubMed  CAS  Google Scholar 

  • Duffy JC. Alcohol consumption and all-cause mortality. Int J Epidemiol 24:100–105, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Dunne FJ. Alcohol and the immune system. A causative agent in altering host defence mechanisms. Br Med J 298:543–544, 1989.

    Article  CAS  Google Scholar 

  • Enstrom JE. Colorectal cancer and beer drinking. Br J Cancer 35:674–683, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Feinberg AP, Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301:89–92, 1983.

    Article  PubMed  CAS  Google Scholar 

  • Ferraroni M, Negri E, La Vecchia C, et al. Socioeconomic indicators, tobacco and alcohol in the aetiology of digestive tract neoplasms. Int J Epidemiol 18:556–562, 1989.

    Article  PubMed  CAS  Google Scholar 

  • Finkelstein JD, Cello JP, Kyle WE. Ethanol-induced changes in methionine metabolism in rat liver. Biochem Biophys Res 61:525–531, 1974.

    Article  CAS  Google Scholar 

  • Freudenheim JL, Graham S, Marshall JR, et al. Lifetime alcohol intake and risk of rectal cancer in Western New York. Nutr Cancer 13:101–109, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Fuchs CS, Stampfer MJ, Colditz GA, et al. Alcohol consumption and mortality among women. N Engl J Med 332:1245–1250, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Gapstur SM, Potter JD, Folsom AR. Alcohol consumption and colon and rectal cancer in postmenopausal woman. Int J Epidemiol 23:50–57, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Garland C, Shekelle RB, Barrett-Connor E, et al. Dietary vitamin D and calcium and risk of colorectal cancer: a 19 years prospective study in men. Lancet 1:307–309, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Garro AJ, McBeth DL, Lima V, et al. Ethanol consumption inhibits fetal DNA methylation in mice: implications for the fetal alcohol syndrome. Alcohol Clin Exp Res 15:395–398, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Garzon FT, Seitz HK, Simanowski UA, et al. Enhancement of acetoxymethylmethylnitrosamine (AMMN) induced colorectal tumours following ethanol consumption in rats. Gastroenterology 90:1424, 1986 (Abstr).

    Google Scholar 

  • Giovannucci E, Hunter D, Colditz G et al. Alcohol consumption and risk of large bowel cancer in women. Am J Epidemiol 142:570, 1995b (Abst 279).

    Google Scholar 

  • Giovannucci E, Rimm EB, Ascherio A, et al. Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 87:265–273, 1995a.

    Article  PubMed  CAS  Google Scholar 

  • Giovannucci E, Stampfer MJ, Colditz GA, et al. Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 85:875–884, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Goelz SE, Vogelstein B, Hamilton SR, et al. Hypomethylation of DNA in benign and malignant human colon neoplasms. Science 228:187–190, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Goldbohm RA, van den Brandt PA, van’t Veer P, et al. Prospective study of alcohol consumption and the risk of cancer of the colon and rectum in the Netherlands. Cancer Causes Control 5:95–104, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Gordon T, Kannel W. Drinking and mortality. Am J Epidemiol 120:97–107, 1984.

    PubMed  CAS  Google Scholar 

  • Graham S, Dayal H, Swanson M, et al. Diet in the epidemiology of cancer of the colon and rectum. JNCI 61:709–714, 1978.

    PubMed  CAS  Google Scholar 

  • Hamilton SR. Structure of the colon. Scand J Gastroenterol 18 Suppl 93:12–23, 1984.

    Google Scholar 

  • Hamilton SR, Hyland J, McAvinchey D, et al. Effects of chronic dietary beer and ethanol consumption on experimental colonic carcinogenesis by azoxymethane in rats. Cancer Res 47:1551–1559, 1987.

    PubMed  CAS  Google Scholar 

  • Hamilton SR, Sohn OS, Fiala ES. Inhibition by dietary ethanol of experimental colonic carcinogenesis by high-dose azodymethane in F344 rats. Cancer Res 48:3313–3318, 1988.

    PubMed  CAS  Google Scholar 

  • Higginson J. Etiological factors in gastrointestinal cancer in man. JNCI 37:527–545, 1966.

    PubMed  CAS  Google Scholar 

  • Hinds MW, Kolonel LB, Lee J, et al. Associations between cancer incidence and alcohol/cigarette consumption among five ethnic groups in Hawaii. Br J Cancer 41:929–940, 1980.

    Article  PubMed  CAS  Google Scholar 

  • Hirayama T. Association between alcohol consumption and cancer of the sigmoid colon: observations from a Japanese cohort study. Lancet 1:725–727, 1989.

    Article  Google Scholar 

  • Holden C. Alcoholism and the medical cost crunch. Science 235:1132–1133, 1987.

    Article  PubMed  CAS  Google Scholar 

  • Honjo S, Kono S, Shinchi K, et al. Cigarette smoking, alcohol use and adenomatous polyps of the sigmoid colon. Jpn J Cancer Res 83:806–811, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Hoshiyama Y, Sekine T, Sasaba T. A case-control study of colorectal cancer and its relation to diet, cigarettes and alcohol consumption in Saitana Prefecture, Japan. Tokyo J Exp Med 171:153–165, 1993.

    Article  CAS  Google Scholar 

  • Howarth AE, Pihl E. High fat diet promotes and causes distal shift of experimental rat colonic cancer — beer and alcohol do not. Nutr Cancer 6:229–235, 1985.

    Article  Google Scholar 

  • Hu J, Liu Y, Yu Y, et al. Diet and cancer of the colon and rectum: a case-control study in China. Int J Epidemiol 20:362–367, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Ikuma H, Mitsushima T, Nagatani K. Case-control study of the association between cigarette smoking, alcohol and colorectal adenomas. Gastroenterology 106:A395, 1994.

    Google Scholar 

  • Iscovich JM, L’Abbe KA, Castelleto R, et al. Colon cancer in Argentin. I. Risk from intake of dietary items. Int J Cancer 51:851–857, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Jacobson JS, Neugut AI, Murray T, et al. Cigarettes smoking and other behavioural risk factor for recurrence of colorectal adenomatous polyps. Cancer Causes Control 5:215–220, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Jarebinski M, Adanja B, Vlajinac H. Case control study of relationships of some biosocial correlates to rectal cancer patients in Belgrade, Yugoslavia. Neoplasma 36:369–374, 1989.

    PubMed  CAS  Google Scholar 

  • Jensen OM. Cancer morbidity and causes of death among Danish brewery workers. Int J Cancer 23:454–463, 1979.

    Article  PubMed  CAS  Google Scholar 

  • Kabat GC, Howson CP, Wynder EL. Beer consumption and rectal cancer. Int J Epidemiol 15:494–501, 1986.

    Article  PubMed  CAS  Google Scholar 

  • Kato I, Tominaga S, Ikari A. A case-control study of male colorectal cancer in Aichi Prefecture, Japan: with special reference to occupational activity level, drinking habits and family history. Jpn J Cancer Res 81:115–121, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Kato I, Tominaga S, Matsuura A, et al. A comparative case-control study of colorectal cancer and adenoma. Jpn J Cancer Res 81:1101–1108, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Kearney J, Giovannucci E, Rimm EB, et al. Diet, alcohol and smoking and the occurrence of hyperplastic polyps of the colon and rectum. Cancer Causes Control 6:45–56, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Kikendall JW, Bowen PE, Burgess MB, et al. Cigarettes and alcohol as independent risk factors for colonic adenomas. Gastroenterology 97:660–664, 1989.

    PubMed  CAS  Google Scholar 

  • Kikendall JW, Magnetti C, Burgess M, et al. Vitamin A nutriture and the risk of colonic adenomas. Gastroenterology 106:A401, 1994.

    Google Scholar 

  • Kinlen LJ. Aetiology. Chapter in: Colorectal Cancer. Recent Results in Cancer Research. Berlin: Springer-Verlag, 1982.

    Google Scholar 

  • Klatsky AL, Armstrong MA, Friedman GD, et al. The relation of alcoholic beverage use to colon and rectal cancer. Am J Epidemiol 128:1007–1015, 1988.

    PubMed  CAS  Google Scholar 

  • Knox EG. Foods and diseases. Br J Prev Soc Med 31:71–80, 1977.

    PubMed  CAS  Google Scholar 

  • Kono S, Ikeda M. Correlation between cancer mortality and alcoholic beverage in Japan. Br J Cancer 40:449–455, 1979.

    Article  PubMed  CAS  Google Scholar 

  • Kono S, Ikeda M, Tokudome S, et al. Alcohol and cancer in male Japanese physicians. J Cancer Res Clin Oncol 109:82–85, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Kono S, Ikeda N, Yanai F, et al. Alcoholic beverages and adenomatous polyps of the sigmoid colon: a study of male self-defence officials in Japan. Int J Epidemiol 19:848–852, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Krebs C. Experimentaller alkohol krebs bei weissen maussen. Immunol Exp Ther 59:203–218, 1928.

    Google Scholar 

  • Kune GA, Kune S, Read A, et al. Colorectal polyps, diet, alcohol and family history of colorectal cancer: a case-control study. Nutr Cancer 16:25–30, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Kune GA, Vitetta L. Alcohol consumption and the etiology of colorectal cancer: a review of the scientific evidence from 1957 to 1991. Nutr Cancer 18:97–111, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Kune S, Kune GA, Watson LF. Case-control study of alcoholic beverages as etiologic factors: the Melbourne colorectal cancer study. Nutr Cancer 9:43–56, 1987a.

    Article  PubMed  CAS  Google Scholar 

  • Kune S, Kune GA, Watson LF. Case-control study of dietary etiological factors: the Melbourne colorectal cancer study. Nutr Cancer 9:21–42,1987b.

    Article  PubMed  CAS  Google Scholar 

  • La Vecchia C, Negri E, De Carli A, et al. A case control study of diet and colorectal cancer in Northern Italy. Int J Cancer 41:492–498, 1988.

    Article  PubMed  Google Scholar 

  • Lee WC, Neugut AI, Garbowski GC, et al. Cigarettes, alcohol, coffee and caffeine as risk factors for colorectal adenomatous polyps. Ann Epidemiol 3:239–244, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Logan RF, Little J, Turner ID, et al. Do smokers and drinks have an increased risk of colorectal adenomas? Gut 32:A1241, 1991.

    Google Scholar 

  • Longnecker MP, Orza MJ, Adams ME, et al. A meta-analysis of alcoholic beverage consumption in relation to risk of colorectal cancer. Cancer Causes Control 1:59–68, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Longnecker MP. A case control study of alcoholic beverage consumption in relation to risk of cancer of the right colon and rectum in men. Cancer Causes and Control 1:5–14, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Macquart-Moulin G, Riboli E, Cornee J, et al. Case-control study of colorectal cancer and diet in Marseilles. Int J Cancer 38:183–191, 1986.

    Article  PubMed  CAS  Google Scholar 

  • Manoussos O, Day NE, Trichopoulos D, et al. Diet and colorectal cancer: a case-control study in Greece. Int J Cancer 32:1–5, 1983.

    Article  Google Scholar 

  • Martinez ME, McPherson RS, Annegers JF, et al. Cigarette smoking and alcohol consumption as risk factors for colorectal adenomatous polyps. J Natl Cancer Inst 87:274–279, 1995.

    Article  PubMed  CAS  Google Scholar 

  • McGarrity TJ, Erwin B, Pegg AE, et al. Polyamine levels in dimethylhydrozaine (DMH) induced colorectal cancer: the effects of chronic alcohol. Gastroenterology 90:1543, 1986 (Abstr).

    Google Scholar 

  • Meyer F, White E. Alcohol and nutrients in relation to colon cancer in middle-aged adults. Am J Epidemiol 138:225–236, 1993.

    PubMed  CAS  Google Scholar 

  • Miller AB, Gowe GR, Jain M, et al. Food items and food groups as risk factors in a case control study of diet and colorectal cancer. Int J Cancer 32:155–161, 1983.

    Article  PubMed  CAS  Google Scholar 

  • Modan B, Barell V, Lubin F, et al. Low fiber intake as an etiologic factor in cancer of the colon. JNCI 55:15–18, 1975.

    PubMed  CAS  Google Scholar 

  • Naveau S, Barthelemy P, Belda E, et al. Alcoholism and cirrhosis, independent risk factors of increased colonic epithelial proliferation. Gastroenterology 108:A514, 1995.

    Google Scholar 

  • Naveau S, Chaput JC, Bedossa P, et al. Cirrhosis as an independent risk factor for colonic adenomas. Gut 33:535–540, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Nelson JC, Liff JM, Nelson EW. Alcohol use and cigarette smoking in the development of colorectal neoplasia. Gastroenterology 104:A390, 1993.

    Google Scholar 

  • Nelson RL, Davis FG, Sutter E, et al. Body iron stores and risk of colonic neoplasia. J Natl Cancer Inst 86:455–460, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Nelson RL, Samelson SL. Neither dietary ethanol nor beer augments experimental colon carcinogenesis in rats. Dis Colon Rectum 28:460–462, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Nestel PJ, Simons LA, Homa Y. Effects of ethanol on bile acid and cholesterol metabolism. Am J Clin Nutr 29:1007–1015, 1976.

    PubMed  CAS  Google Scholar 

  • Newcomb PA, Storer BE, Marcus PM. Cancer of the large bowel in women in relation to alcohol consumption: a case-control study in Wisconsin (United States). Cancer Causes Control 4:4–5–411, 1993.

    Article  Google Scholar 

  • Niwa K, Tanaka T, Sugie S, et al. Enhancing effect of ethanol or sake on methylazoxymethanol acetate-initiated large bowel carcinogenesis in ACI/N rats. Nutr Cancer 15:229–237, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Olsen J, Kronberg O. Coffee, tobacco and alcohol as risk factors for cancer and adenoma of the large intestine. Int J Epidemiol 22:398–402, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Olsen J, Kronborg O. Consumption of coffee, tobacco and alcohol as risk factors for cancer and adenoma of the large intestine. Int J Epid 22:398–402, 1993.

    Article  CAS  Google Scholar 

  • Pascale RM, Simile MM, Satta G, et al. Comparative effects of L-methionine, S-adenosyl-L-methionine and 5-methylthiodenosine on the growth of preneoplastic lesions and DNA methylation in rat liver during the early stages of hepatocinogenesis. Anticancer Res 11:1617–1624, 1991.

    PubMed  CAS  Google Scholar 

  • Pernu J. An epidemiological study on cancer of the digestive organs and respiratory system. A study based on 7028 cases. Ann Med Intern Fenn 49:1–117, 1960.

    Google Scholar 

  • Peters RK, Garabrant DH, Yu MC, et al. A case-control study of occupational and dietary factors in colorectal cancer in young men by subsite. Cancer Res 49:5459–5468, 1989.

    PubMed  CAS  Google Scholar 

  • Peters RK, Pike MC, Garabrant D, et al. Diet and colon cancer in Los Angeles County, California. Cancer Causes Control 3:457–473, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Pickle LW, Green MH, Ziegler RG, et al. Colorectal cancer in rural Nebraska. Cancer Res 44:363–369, 1984.

    PubMed  CAS  Google Scholar 

  • Pollack ES, Nomura AMY, Heilbrun LK, et al. Prospective study of alcohol consumption and cancer. N Engl J Med 310:617–621, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Porta EA, Markell N, Dorado RD. Chronic alcoholism enhances hepatocarcinogenicity of diethylnitrosamine in rats fed a marginally methyl-deficient diet. Hepatology 5:1120–1125, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Potter JD, McMichael AJ. Diet and cancer of the colon and rectum: a case-control study. JNCI 76:557–569, 1986.

    PubMed  CAS  Google Scholar 

  • Potter JD, McMichael AJ, Hartshorne JM. Alcohol and beer consumption in relation to cancers of the bowel and lung: an extended correlation analysis. J Chronic Dis 35:833–842, 1982.

    Article  PubMed  CAS  Google Scholar 

  • Preston-Martin S, Pike MC, Ross RK, et al. Increased cell division as a cause of human cancer. Cancer Res 40:403–405, 1990.

    Google Scholar 

  • Probert CJS, Emmett PM, Heaton KW. Some determinants of whole-gut transit-time: a population-based study. Quart J Med 88:311–315, 1995.

    CAS  Google Scholar 

  • Riboli E, Cornee J, Macquart-Moulin G, et al. Cancer and polyps of the colorectum and lifetime consumption of beer and other alcoholic beverages. Am J Epidemiol 134:157–166, 1991.

    PubMed  CAS  Google Scholar 

  • Rozen P, Lubin F, Arieli B, et al. Nutritional and other life habits in colorectal adenoma etiology. Cancer Res 35:295, 1994.

    Google Scholar 

  • Sandler RS, Lyles CM, McAuliffe C, et al. Cigarette smoking, alcohol and the risk of colorectal adenoma. Gastroenterology 104:1445–1451, 1993.

    PubMed  CAS  Google Scholar 

  • Scanlan RA. Formation and occurrence of nitrosamines in food. Cancer Res 43:2435–2440, 1983.

    CAS  Google Scholar 

  • Scanlan RA, Barbour JF. N-nitrosodimethylamine content of US and Canadian beers. In: Relevance to Human Cancer of N-Nitroso Compounds, Tobacco Smoke and Mycotoxins. O’Neill IK, Chen J, Bartsch H (eds), Lyon, France: IARC 1991, pp 242–243 (Publ No. 105).

    Google Scholar 

  • Seitz HK, Czygan P, Waldherr R, et al. Enhancement of 1,2-dimethyl-carcinogenesis following chronic ethanol consumption in the rat. Gastroenterology 86:886–891, 1984.

    PubMed  CAS  Google Scholar 

  • Simanowski VA, Seitz HK, Baier B, et al. Chronic ethanol consumption selectively stimulates rectal cell proliferation in the rat. Gut 27:278–282, 1986.

    Article  PubMed  CAS  Google Scholar 

  • Simanowski VA, Suter P, Ward R, et al. Ethanol induced rectal hyper-regeneration is strikingly enhanced with age, possibly due to an acetaldehyde mediated mechanism. Gastroenterology 100:A547, 1991.

    Google Scholar 

  • Soon OS, Fiala ES, Puz C, et al. Enhancement of azoxymethane (AOM) and methylazoxymethanol (MOM) metabolism by liver microsomes following chronic ethanol administration to rats. Cancer Res 27:120, 1986.

    Google Scholar 

  • Stemmerman GN, Heilbrun LK, Nomura A. Association of diet and other factors with adenomatous polyps of the large bowel: a prospective autopsy study. Am J Clin Nutr 47:312–317, 1988.

    Google Scholar 

  • Stemmermann GN, Nomura AMY, Chyou PH, et al. Prospective study of alcohol intake and large bowel cancer. Dig Dis Sci 35:1414–1420, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Stockbrügger RW, Adang RP, Maads B, et al. Risk factor profile for rectosigmoid adenomas: a prospective screening study of 665 patients in a clinical rehabilitation centre. Gastroenterology 106:A443, 1994.

    Google Scholar 

  • Stocks P. Cancer incidence in North Wales and Liverpool region in relation to habits and environment. Suppl Pt II Br Empire Cancer Campaign 35th Ann Rep 1957.

    Google Scholar 

  • Swann PF, Code AM, Mace R. Ethanol and dimethylnitrosamine and diethylnitrosamine metabolism and disposition in the rat. Possible relevance to the influence of ethanol on human cancer incidence. Carcinogenesis 5:1337–1343, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Tajima K, Tominaga S. Dietary habits and gastro-intestinal cancers: a comparative study of stomach and large intestinal cancers in Nagoya, Japan. Jpn J Cancer Res 76:705–716, 1985.

    PubMed  CAS  Google Scholar 

  • Terraroni M, Negri E, La Vecchia C, et al. Socioeconomic indicators tobacco and alcohol in the aetiology of digestive tract neoplasma. Int J Epidemiol 18:556–562, 1989.

    Article  Google Scholar 

  • Thornton J, Symes C, Heaton K. Moderate alcohol intake reduces bile cholesterol saturation and raises HDL cholesterol. Lancet 2:819–822, 1983.

    Article  PubMed  CAS  Google Scholar 

  • Tuyns A, Kaaks R, Haelterman M. Colorectal cancer and the consumption of food: a case control study in Belgium. Nutr Cancer 11:189–204, 1988.

    Article  PubMed  CAS  Google Scholar 

  • Tuyns AJ, Pequignot G, Gignoux M, et al. A cancer of the digestive tract, alcohol and tobacco. Int J Cancer 30:9–11, 1982.

    Article  PubMed  CAS  Google Scholar 

  • Vobecky J, Caro J, Devroede G. A case control study of risk factors for large bowel carcinoma. Cancer 51:1958–1963, 1983.

    Article  PubMed  CAS  Google Scholar 

  • Walker EA, Castegnaro M, Garren L, et al. Intake of volatile nitrosamines from consumption of alcohols. JNCI 63:947–951, 1979.

    PubMed  CAS  Google Scholar 

  • Ward K, Moriarty KJ, O’Neill S, et al. Alcohol and colorectal cancer. Gut 24:A981, 1983.

    Article  Google Scholar 

  • Williams RR, Horm JW. Association of cancer sites with tobacco and alcohol consumption and socioeconomic status of patients: interview study from the Third National Cancer Survey. JNCI 58:525–547, 1977.

    PubMed  CAS  Google Scholar 

  • Wu AH, Paganini-Hill A, Ross RK, et al. Alcohol, physical activity and other risk factors for colorectal cancer: a prospective study. Br J Cancer 55:687–694, 1987.

    Article  PubMed  CAS  Google Scholar 

  • Wynder EL, Kajitani T, Ishakawa S, et al. Environmental factors of cancer of the colon and rectum. II. Japanese Epidemiological Data. Cancer 23:1210–1220, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Wynder EL, Shigematsu T. Environmental factors of cancer of the colon and rectum. Cancer 20:1520–1561, 1967.

    Article  PubMed  CAS  Google Scholar 

  • Wynder EL, Stellman SD. The “over-exposed” control group. Am J Epidemiol 135:459–461, 1992.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

Kune, G.A. (1996). Alcohol Consumption. In: Causes and Control of Colorectal Cancer. Developments in Oncology, vol 78. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1273-4_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1273-4_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8543-4

  • Online ISBN: 978-1-4613-1273-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics