Morphology of Colorectal Neoplasia

  • Gabriel A. Kune
Part of the Developments in Oncology book series (DION, volume 78)


The aspects of morphology which are relevant to the understanding of colorectal tumor etiology and prevention are discussed in this chapter. Up to the mid-1980s histopathologists were comfortable in the belief that most colorectal cancers commenced in an adenoma, that only a few adenomas became malignant, and that in a few instances a colorectal tumor develops “de novo”. In the 1980s the recognition of aberrant crypt foci, microadenomas and flat adenomas together with associated molecular genetic changes, however, has necessitated a major reexamination of the morphologic pathways to colorectal cancer.


Colorectal Cancer Colorectal Adenoma Hyperplastic Polyp Aberrant Crypt Focus Colorectal Neoplasia 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Gabriel A. Kune
    • 1
    • 2
  1. 1.University of MelbourneAustralia
  2. 2.Melbourne Colorectal Cancer StudyAustralia

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