Skip to main content

Primary Prevention of Colorectal Tumors

  • Chapter
Causes and Control of Colorectal Cancer

Part of the book series: Developments in Oncology ((DION,volume 78))

  • 95 Accesses

Abstract

The essence of prevention of illness, including cancer, is the ability of individuals, groups, and of society in general to make changes in behavior.

It seems certain that cancer is to a very great extent preventable. Conquest of predisposition is possible. But the degree of justifiable hope will depend on the strength of the will.

The Honourable Rollo Russell Preventable Cancer. A Statistical Research. Longmans, Green, London 1912.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alabaster O, Tang Z, Frost A, et al. Effect of beta-carotene and wheat bran fiber on colonic aberrant crypt and tumor formation in rats exposed to azoxymethane and high dietary fat. Carcinogenesis 16:127–132, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Alabaster O, Tang ZC, Frost A, et al. Potential synergism between wheat bran and psyllium: enhanced inhibition of colon cancer. Cancer Lett 30:53–58, 1993.

    Article  Google Scholar 

  • Anti M, Armelao F, Marra G, et al. Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. Gastroenterology 107:1709–1718, 1994.

    PubMed  CAS  Google Scholar 

  • Armitage NC, Rooney PS, Gifford KA, at al. The effect of calcium supplements on rectal mucosal proliferation. Br J Cancer 71:186–190, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Baron JA, Tosteson TD, Wargovich MJ, et al. Calcium supplementation and rectal mucosal proliferation: a randomized controlled trial. J Natl Cancer Inst 87:1303–1307, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Barsoum GH, Hendrickse C, Winslet MC, et al. Reduction of mucosal crypt cell proliferation in patients with colorectal adenomatous polyps by dietary calcium supplementation. Br J Surg 79:581–583, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Beeson WL, Mills PK, Phillips RL, et al. Chronic disease among Seventh Day Adventists. A low risk group. Rationale, methodology and description of the population. Cancer 64:570–581, 1989.

    Article  PubMed  CAS  Google Scholar 

  • Berkel J, de Waard F. Mortality pattern and life expectancy of Seventh Day Adventists in the Netherlands. Int J Epidemiol 12:455–459, 1983.

    Article  PubMed  CAS  Google Scholar 

  • Bomalaski JS, Hirata F, Clark MA. Aspirin inhibits phospholipase C. Biochem Biophys Res Commun 139:115–121, 1986.

    Article  PubMed  CAS  Google Scholar 

  • Bostick RM, Fosdick L, Wood JR, et al. Calcium and colorectal epithtlial cell proliferation in sporadic adenoma patients: a randomized double-blinded, placebo-controlled clinical trial. J Natl Cancer Inst 87:1307–1315, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Bussey JH, DeCosse JJ, Deschner EE, et al. A randomized trial of ascorbic acid in polyposis coli. Cancer 50:1434–1439, 1982.

    Article  PubMed  CAS  Google Scholar 

  • Cahill RJ, O’Sullivan KR, Mathias PM, et al. Effects of vitamin antioxidant supplementation on cell kinetics of patients with adenomatous polyps. Gut 34:963–967, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Cats A, Kleibeuker JH, Van der Meer R, et al. Randomized double-blinded, placebo-controlled intervention study with supplemental calcium in families with hereditary non-polyposis colorectal cancer. J Natl Cancer Inst 87:598–603, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Cheng JY, Meng CL, Tzeng CC, et al. Optimal dose of garlic to inhibit dimethylhydrazine-induced colon cancer. World J Surg 19:621–625, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Chu KC, Tarone RE, Chow WH, et al. Temporal patterns in colorectal cancer incidence, survival and mortality from 1950 through 1990. J Natl Cancer Inst 86:997–1006, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Courtney JG, Longnecker MP, Theorell T, et al. Stressful life events and the risk of colorectal cancer. Epidemiology 4:407–414, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Craven PA, DeRubertis FR. Effects of aspirin on 1,2-dimethylhydrazine-induced colonic carcinogenesis. Carcinogenesis 13:541–546, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Cummings JH, Bingham SA, Heaton KW, et al. Fecal weight, colon cancer risk and dietary intake of non-starch polysaccharides (dietary fiber). Gastroenterology 103:1783–1789, 1992.

    PubMed  CAS  Google Scholar 

  • Dayton S, Pearce ML, Hashimoto S, et al. A controlled clinical trial of a diet high in unsaturated fat in preventing complications of atherosclerosis. Circulation 40 (Suppl II): 1–63, 1969.

    Google Scholar 

  • DeCosse JJ, Miller HH, Lesser ML. Effect of wheat fiber and vitamins C and E on rectal polyps in patients with familial adenomatous polyposis. J Natl Cancer Inst 81:1290–1297, 1989.

    Article  PubMed  CAS  Google Scholar 

  • Doll R, Peto R, Wheatley K, et al. Mortality in relation to smoking: 40 years’ observations on male British doctors. Br Med J 309:901–911, 1994.

    CAS  Google Scholar 

  • Earnest D, Batta A, Holubec H, et al. Chemoprevention of colon cancer by ursodeoxycholic acid: a possible mechanism of action. Gastroenterology 108:A463, 1995.

    Google Scholar 

  • Eberhart CE, Coffey RJ, Radhika A, et al. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107:1183–1188, 1994.

    PubMed  CAS  Google Scholar 

  • Ederer F, Leren P, Turpeinen O, et al. Cancer among men on cholesterol-lowering diets: experience from five clinical trials. Lancet ii:203–206, 1971.

    Google Scholar 

  • Faivre J, Boutron MC, Doyon F, et al. The ECP calcium fibre polyp prevention study. Preliminary report. Eur J Cancer Prevention 2 (Suppl 2):99–106, 1993.

    Article  Google Scholar 

  • Frentzel-Beyme R, Chang-Claude J. Vegetarian diets and colon cancer: the German experience. Am J Clin Nutr 59 (Suppl 5):1143S–1152S, 1994.

    CAS  Google Scholar 

  • Frentzel-Beyme R, Claude J, Eilber V. Mortality among German vegetarians: first results after five years of follow-up. Nutr Cancer 11:117–126, 1988.

    Article  PubMed  CAS  Google Scholar 

  • Friedewald WT, Kuller LH, Ockene JK. Primary prevention of cancer: relevant multiple risk factor intervention trial results. In: Evaluating Effectiveness of Primary Prevention of Cancer. M. Hakama, V. Beral, JW Cullen, DM Parkin (eds) Lyon: IARC Scientific Publication 103, pp 157–170.

    Google Scholar 

  • Furukawa K, Yamamoto I, Tanida N, et al. The effects of dietary fiber from Lagenaria scineraria (yugao-melon) on colonic carcinogenesis in mice. Cancer 75 (Suppl 6):1508–1515, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Gann PH, Manson JE, Glynn RJ, et al. Low-dose aspirin and incidence of colorectal tumors in a randomized trial. J Natl Cancer Inst 85:1220–1224, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Gapstur SM, Potter JD, Folsom AR. Alcohol consumption and colon and rectal cancer in postmenopausal women. Int J Epidemiol 23:50–57, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Giardiello FM, Hamilton SR, Krush AJ, et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med 328:1313–1316, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Giovannucci E, Egan KM, Hunter DJ, et al. Aspirin and the risk of colorectal cancer in women. N Engl J Med 333:609–614, 1995a.

    Article  CAS  Google Scholar 

  • Giovannucci E, Rimm EB, Acscherio A, et al. Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 87:265–273, 1995b.

    Article  CAS  Google Scholar 

  • Giovannucci E, Rimm EB, Stampfer MJ, et al. Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med 121:241–246, 1994.

    PubMed  CAS  Google Scholar 

  • Giovannucci E, Stampfer MJ, Colditz GA, et al. Folate, methionine and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 85:875–884, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Greenberg ER, Baron JA, Freeman DH Jr, et al. Reduced risk of large-bowel adenomas among aspirin users. J Natl Cancer Inst 85:912–916, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Greenberg ER, Baron JA, Tosteson TD, et al. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N Engl J Med 331:141–147, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Gridley G, McLaughlin JK, Ekbom A, et al. Incidence of cancer among patients with rheumatoid arthritis. J Natl Cancer Inst 85:307–311, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Hakulinen T, Pukkala E, Kenward M, et al. Changes in cancer incidence in North Karelia, an area with a comprehensive preventive cardiovascular programme. In: Evaluating Effectiveness of Primary Prevention of Cancer. M. Hakama, V. Beral, JW Cullen, DM Parkin (eds) Lyon: IARC Scientific Publication No. 103, pp 133–148.

    Google Scholar 

  • Hjermann I, Velve-Byre K, Holme I, et al. Effect of diet and smoking intervention on the incidence of coronary heart disease: report from the Oslo Study Group of a randomised trial in healthy men. Lancet ii:1303–1310, 1981.

    Article  Google Scholar 

  • Huang MT, Lou YR, Ma W, et al. Inhibitory effects of dietary curcumin on forestomach, duodenal and colon carcinogenesis in mice. Cancer Res 54:5841–5847, 1994.

    PubMed  CAS  Google Scholar 

  • Ishikawa H, Akedo I, Suzuki T, et al. Interventional trial for colorectal cancer prevention in Osaka: an introduction to the protocol. Jpn J Cancer Res 86:707–710, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Jacobson JS, Neugut AI, Murray T, et al. Cigarette smoking and other behavioral risk factors for recurrence of colorectal adenomatous polyps (New York City, NY, USA). Cancer Causes Control 5:215–220, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Jensen OM. Cancer risk among Danish male Seventh-Day Adventists and other temperance society members. J Natl Cancer Inst 70:1010–1014, 1983.

    Google Scholar 

  • Johanson JF, Salisbury D. Effectiveness of aspirin in preventing colorectal adenomas: Does dose matter? Gastroenterology 108:A486, 1995.

    Article  Google Scholar 

  • Kampman E, Giovannucci E, van’t Veer P, et al. Calcium, vitamin D, diary foods and the occurrence of colorectal adenomas among men and women in two prospective studies. Am J Epidemiol 139:16–29, 1994.

    PubMed  CAS  Google Scholar 

  • Kargman SL, O’Neill GP, Vickers PJ, et al. Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res 55:2556–2559, 1995.

    PubMed  CAS  Google Scholar 

  • Kawamori T, Tanaka T, Ohnishi M, et al. Chemoprevention of azoxymethane-induced colon carcinogenesis by dietary feeding of S-methyl methane thiosulfonate in male F344 rats. Cancer Res 55:4053–4058, 1995.

    PubMed  CAS  Google Scholar 

  • Kawamori T, Tanaka T, Suzui M, et al. Chemoprevention of azoxymethane-induced intestinal carcinogenesis by a novel synthesized retinoidal butenolide. Carcinogenesis 16:795–800, 1995b.

    Article  CAS  Google Scholar 

  • Kilias D, Macrae FA, Hughes N, et al. Rectal epithelial cell kinetics measured after four years of dietary intervention. A randomized controlled trial. J Gastroenterol Hepatol 8:A7, 1993.

    Article  Google Scholar 

  • Kleibeuker JH, Cats A, van der Meer R, et al. Calcium supplementation as prophylaxis against colon cancer? Dig Dis 12:85–97, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Koutsos MI, Schiff SJ, Qiao L, et al. Aspirin and other NSAIDs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. Gastroenterology 108:A492, 1995a.

    Google Scholar 

  • Koutsos MI, Schiff SJ, Rigas B. The effect of ursodeoxycholic and lithocholic acid on cell cycle and apoptosis in human colon adenocarcinoma cells. Gastroenterology 108.A492, 1995b.

    Google Scholar 

  • Kulkarni N, Reddy BS. Inhibitory effect of bifodobacterium longum cultures on the azoxymethane-induced aberrant crypt foci formation and fecal bacterial beta-glucuronidase. Proc Soc Exp Biol Med 207:278–283, 1994.

    PubMed  CAS  Google Scholar 

  • Kune GA. The psyche and the development of malignant disease. In: The Psyche and Cancer. GA Kune, S. Bannerman (eds) University of Melbourne 1992, pp 11–14, ISBN 0 7325 0502 X.

    Google Scholar 

  • Kune GA, Bannerman S, Watson LF. Attributable risk for diet, alcohol, and family history in the Melbourne colorectal cancer study. Nutr Cancer 18:231–235, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Kune GA, Kune S. New design to examine colorectal cancer cause and survival. The Melbourne colorectal cancer study. Dig Surg 4:156–159, 1987.

    Article  Google Scholar 

  • Kune GA, Kune S. The Melbourne colorectal cancer study. A description of the investigation. University of Melbourne 1986, pp 1–31, ISBN 0 86839 596X.

    Google Scholar 

  • Kune GA, Kune S, Watson LF. Colorectal cancer risk, chronic illnesses, operations and medications: case-control results from the Melbourne colorectal cancer study. Cancer Res 48:4399–4404, 1988.

    PubMed  CAS  Google Scholar 

  • Kune GA, Vitetta L. Alcohol consumption and the etiology of colorectal cancer: a review of the scientific evidence from 1957 to 1991. Nutr Cancer 18:97–111, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Kune GA, Vitetta L. The causes of colorectal adenomas: the key to the prevention of colorectal cancer? J Royal Soc Med 88:625–628, 1995.

    CAS  Google Scholar 

  • Kune S. Stressful life events and cancer. Epidemiology 4:395–397, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Kune S, Kune GA, Watson LF. Case-control study of alcoholic beverages as etiological factors. The Melbourne colorectal cancer study. Nutr Cancer 9:43–56, 1987b.

    Article  CAS  Google Scholar 

  • Kune S, Kune GA, Watson LF. Case-control study of dietary etiological factors: the Melbourne colorectal cancer study. Nutr Cancer 9:21–42, 1987a.

    Article  CAS  Google Scholar 

  • Kune S, Kune GA, Watson LF, Rahe RH. Recent life change and large bowel cancer: data from the Melbourne colorectal cancer study. J Clin Epidemiol 44:57–68, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Labayle D, Fischer D, Vielh D, et al. Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology 101:635–639, 1991.

    PubMed  CAS  Google Scholar 

  • Ladenheim J, Garcia G, Titzer D, et al. Effect of Sulindac on sporadic colonic polyps. Gastroenterology 108:1083–1087, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Leren P. The Oslo Diet-Heart study: eleven-year report. Circulation 42:935–942, 1970.

    PubMed  CAS  Google Scholar 

  • Limburg PJ, Ahlquist DA, Talley NJ, et al. Decreased risk of colorectal cancer associated with peptic ulcer disease: a cohort study. Gastroenterology 106:A409, 1994.

    Google Scholar 

  • Lipkin M. Biomarkers of increased susceptibility to gastrointestinal cancer: New application to studies of cancer prevention in human subjects. Cancer Res 48:235–245, 1988.

    PubMed  CAS  Google Scholar 

  • Lippmann SM, Lee JS, Lotan R, et al. Biomarkers as intermediate endpoints in chemoprevention trials. J Natl Cancer Inst 82:555–560, 1990.

    Article  Google Scholar 

  • Logan RFA, Little J, Hawtin PG, et al. Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme. Br Med J 307:285–289, 1993.

    Article  CAS  Google Scholar 

  • Logan RFA, Little J, Smith S, et al. Aspirin and non-steroidal anti-inflammatory drug (NSAID) use and symptomatic colorectal cancer: a case-control study. Gastroenterology 106:A546, 1994 and

    Google Scholar 

  • Logan RFA, Little J, Smith S, et al. Aspirin and non-steroidal anti-inflammatory drug (NSAID) use and symptomatic colorectal cancer: a case-control study Gut 35:51, 1994.

    Article  Google Scholar 

  • Lubin F, Boeing H, Rozen P. Design and background of the Tel Aviv-Heidelberg dietary study of colonic adenoma patients and calcium intervention trial. Front Gastroenterol Res 18:74–87, 1991.

    Google Scholar 

  • MacLennan R, Macrae FA, Bain C, et al. Effect of fat, fiber, and beta-carotene intake on colorectal adenomas: a randomized controlled dietary intervention trial after colonoscopic polypectomy. J Natl Cancer Inst (accepted for publication 1995).

    Google Scholar 

  • MacLennan R, Ward M, Macrae F, et al. Effect of fat, fiber and beta-carotene intake on occurrence of colorectal adenomas after 24 months. Gastroenterology 100:A382, 1991.

    Google Scholar 

  • Macrae F, MacLennan R, Ward M, et al. A randomised controlled trial of fat, fibre and beta-carotene on colorectal adenomas. Gastroenterology 108:A501, 1995

    Google Scholar 

  • Macrae FA, Hughes NR, Bhathal PS, et al. Dietary suppression of rectal epithelial cell proliferation. Gastroenterology 100:A383, 1991.

    Google Scholar 

  • Macrae FA, Kilias D, Sharpe K, et al. Rectal epithelial cell proliferation: comparison of errors of measurement with intersubject variance. J Cell Biochem 19:84–90, 1994a (Suppl).

    CAS  Google Scholar 

  • Macrae FA, Russell A, MacLennan R, et al. Aspirin effects on large adenomas. Gastroenterology 106:A411, 1994b.

    Google Scholar 

  • Marcus AJ. Aspirin as prophylaxis against colorectal cancer. N Engl J Med 333:656–658, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Mareto E, Frencia L, Ghia M. Effect of aspirin on incidence and growth of aberrant crypt foci induced in the rat colon by 1,2-dimethylhydrazine. Cancer Lett 76:5–9, 1994.

    Article  Google Scholar 

  • Marnett LJ. Aspirin and the potential role of prostaglandins in colon cancer. Perspectives in cancer research. Cancer Res 52:5575–5589, 1992.

    PubMed  CAS  Google Scholar 

  • Marnett LJ. Aspirin and related nonsteroidal anti-inflammatory drugs as chemopreventive agents against colon cancer. Preventive Med 24:103–106, 1995

    Article  CAS  Google Scholar 

  • McKeown-Eyssen G, Holloway C, Jazmaji V, et al. A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps. Cancer Res 48:4701–4705, 1988.

    PubMed  CAS  Google Scholar 

  • McKeown-Eyssen G, Bright-See E, Bruce WR. Recurrence of colorectal polyps: a randomized trial of low-fat, high-fiber diet. Am J Epidemiol 134:746, 1991.

    Google Scholar 

  • McKeown-Eyssen G, Bright-See E, Bruce WR, et al. A randomized trial of low-fat high fiber diet in the recurrence of colorectal polyps. Toronto Polyp Prevention Group. J Clin Epidemiol 47:525–536, 1994.

    Article  PubMed  CAS  Google Scholar 

  • McLaughlin JK, Hrubec Z, Blot WJ, et al. Smoking and cancer mortality among US veterans: a 26 year follow-up. Int J Cancer 60:190–193, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Mori H, Morishita Y, Shinoda T, et al. Preventive effect of magnesium hydroxide on carcinogen-induced large bowel carcinogenesis in rats. Basic Life Sci 61:111–118, 1993.

    PubMed  CAS  Google Scholar 

  • MRFIT Research Group. Multiple risk factor intervention trial: risk factor changes and mortality results. J Am Med Assoc 248:1465–1477, 1982.

    Article  Google Scholar 

  • Muscat JE, Stellman SD, Wynder EL. Nonsteroidal anti-inflammatory drugs and colorectal cancer. Cancer 74:1847–1854, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Muscat JE, Stellman SD, Wynder EL. Analgesic use and colorectal cancer. Preventive Med 24:110–112, 1995.

    Article  CAS  Google Scholar 

  • Müller AD, Sonnenberg A, Wasserman IH. NSAID-related reduction in the risk of colon cancer. Gastroenterology 106:A19, 1994.

    Google Scholar 

  • Narisawa T, Fakaura Y. A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats. Jpn J Cancer Res 84:1007–1009, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Neugut AI, Garbowski GC, Lee WC, et al. Dietary risk factors for the incidence and recurrence of colorectal adenomatous polyps, a case-control study. Ann Intern Med 118:91–95, 1993.

    PubMed  CAS  Google Scholar 

  • Newcomb PA, Storer BE, Marcus PM. Cancer of the large bowel in women in relation to alcohol consumption: a case-control study in Wisconsin (United States). Cancer Causes Control 4:405–411, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Nordgaard L, Hove H, Clausen MR, et al. Increased colonic production of butyrate from dietary fiber (Plantago) in patients with former colonic cancer. Fourth United European Gastroenterology Week, Berlin, September 1995 (Abstract 2275).

    Google Scholar 

  • Nugent KP, Farmer KC, Spigelman AD, et al. Randomized placebo controlled trial of the effect of Sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. Br J Surg 80:1618–1619, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Paganelli GM, Biasco G, Brandi G, et al. Effect of vitamin A, C and E supplementation on rectal cell proliferation in patients with colorectal adenomas. J Natl Cancer Inst 84:47–51, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Paganini-Hill A. Aspirin and colorectal cancer: the Leisure World cohort revisited. Preventive Med 24:113–115, 1995.

    Article  CAS  Google Scholar 

  • Paganini-Hill A, Chao A, Ross RK, et al. Aspirin use and chronic diseases: a cohort study of the elderly. Br Med J 229:1247–1250, 1989.

    Article  Google Scholar 

  • Paganini-Hill A, Hsu G, Ross RK, et al. Aspirin use and incidence of large-bowel cancer in a California retirement community. J Natl Cancer Inst 83:1182–1183, 1991.

    PubMed  CAS  Google Scholar 

  • Pearce ML, Dayton S. Incidence of cancer in men on a diet high in polyunsaturated fat. Lancet 1:464–467, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Peleg I, Maibach HT, Wilcox CM. Aspirin (ASA) NSAID use and the risk of subsequent colorectal polyps. Gastroenterology 104.A440, 1993.

    Google Scholar 

  • Peleg I, Maibach HT, Brown SH, et al. Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer. Arch Intern Med 154:394–399, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Peleg I, Cotsonis GA, Clark WS, et al. The use of nonsteroidal, but not steroidal anti inflammatory drugs modulates the risk of colorectal adenoma and adenocarcinoma. Gastroenterology 108:A524, 1995.

    Google Scholar 

  • Phillips RL. Role of lifestyle and dietary habits in risk of cancer among Seventh Day Adventists. Cancer Res 35:3513–3522, 1975.

    PubMed  CAS  Google Scholar 

  • Phillips RL, Kuzma JW, Lotz TM. Cancer mortality among comparable members versus non-members of the Seventh Day Adventist Church. In: Cairns J, Lyon JL, Skolnick M (eds). Banfield Report No. 4, Cancer Incidence in Defined Populations, Cold Spring Harbor Laboratory 1980, pp 93–107.

    Google Scholar 

  • Phillips RL, Snowdon DA. Dietary relationships with fatal colorectal cancer among Seventh Day Adventists. J Natl Cancer Inst 74:307–317, 1985.

    PubMed  CAS  Google Scholar 

  • Potter JD. Hormones and colon cancer. J Natl Cancer Inst 87:1039–1040, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Powis G, Alberts DS. Inhibiting intracellular signalling as a strategy for cancer chemoprevention. Eur J Cancer 30A:1138–1144, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Rao AV, Goettler DM, Bird RP. The effects of a “low-risk” diet on tumor incidence in chemically induced colon cancer in rats. Nutr Cancer 11:11–20, 1988.

    Article  PubMed  CAS  Google Scholar 

  • Rao CV, Desai D, Rivenson A, et al. Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate. Cancer Res 55:2310–2315, 1995b.

    PubMed  CAS  Google Scholar 

  • Rao CV, Rivenson A, Kelloff GJ, et al. Chemoprevention of azoxymethane-induced colon cancer by ascorbylpalmitate, carbenoxolone, dimethylfumarate and p-methoxyphenol In male F344rats. Anticancer Res 15:1199–1204, 1995.

    PubMed  CAS  Google Scholar 

  • Rao CV, Rivenson A, Simi B, et al. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res 55:259–266, 1995c.

    PubMed  CAS  Google Scholar 

  • Rao CV, Rivenson A, Simi B, et al. Chemoprevention of colon carcinogenesis by sulindac, a non-steroidal anti-inflammatory agent. Cancer Res 55:1464–1472, 1995a.

    PubMed  CAS  Google Scholar 

  • Rao CV, Simi B, Reddy BS. Inhibition by dietary curcumin of azoxymethane-induced ormithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis 14:2219–2225, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Reddy BS, Tokumo K, Kulharni N, et al. Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related compounds. Carcinogenesis 13:1019–1023, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Reddy BS, Rao CV, Rivenson A, et al. Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats. Carcinogenesis 14:1493–1497, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Reddy BS, Upadhyaya P, Simi B, et al. Evaluation of organoselenium compounds for potential chemopreventive properties in colon carcinogenesis. Anticancer Res 14:2509–2514, 1994.

    PubMed  CAS  Google Scholar 

  • Research Committee. Controlled trial of soya-bean oil in myocardial infarction: report of a research committee to the Medical Research Council. Lancet ii:693–700, 1968.

    Google Scholar 

  • Roncucci L, Di Donato P, Carati L, et al. Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas. Dis Colon Rectum 36:227–234, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Rooney PS, Hunt LM, Clarke PA, et al. Wheat fibre, lactulose and rectal mucosal proliferation in individuals with a family history of colorectal cancer. Br J Surg 81:1792–1794, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Rose G. Comment on the Göteborg study by Wilhelmsen et al. Eur Heart J 7:288, 1986.

    Google Scholar 

  • Rosenberg L, Palmer JR, Zauber AG, et al. A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer. J Natl Cancer Inst 83:355–358, 1991a.

    Article  CAS  Google Scholar 

  • Rosenberg L, Palmer JR, Shapiro S. Response. J Natl Cancer Inst 83:1183, 1991b.

    Article  Google Scholar 

  • Ruffin MT, Krishnan K, Kraus E. Aspirin as a chemopreventive agent for colorectal cancer: lowest dose of aspirin to suppress rectal mucosal prostaglandins. Proc Am Assoc Cancer Res 36:600, 1995 (Abstr).

    Google Scholar 

  • Sano H, Kawahito Y, Wilder RL. Expression of cycloxygenase-1 and -2 in human colorectal cancer. Cancer Res 55:3785–3789, 1995.

    PubMed  CAS  Google Scholar 

  • Schatzkin A, Freedman LS, Schiffman MH, et al. Validation of intermediate endpoints in cancer research. J Natl Cancer Inst 82:1746–1752, 1990a.

    Article  PubMed  CAS  Google Scholar 

  • Schatzkin A, Lanza E, Ballard-Barbash R. The case for a dietary intervention study of large bowel polyps. Cancer Prevention 1:84–90, 1990b.

    Google Scholar 

  • Schatzkin A, Freedman LS, Dawsey SM, et al. Interpreting precursor studies: what polyp trials tell us about large-bowel cancer. J Natl Cancer Inst 86:1053–1057, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Schreinemachers DM, Everson RB. Aspirin use and lung, colon and breast cancer incidence in a prospective study. Epidemiology 5:138–146, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Sellers TA, Kushi LM, Potter JD. Can dietary intake patterns account for the familial aggregation of disease? Evidence from adult siblings living apart. Genetic Epidemiol 8:105–112, 1991.

    Article  CAS  Google Scholar 

  • Shike M, Winawer SJ, Greenwald PH, et al. Primary prevention of colorectal cancer. Bull WHO 68:377–385, 1990.

    PubMed  CAS  Google Scholar 

  • Shivapurkar N, Tang Z, Frost A, et al. Inhibition of progression of aberrant crypt foci and colon tumor development by vitamin E and beta-carotene on a high-risk diet. Cancer Lett 91:125–132, 1995.

    CAS  Google Scholar 

  • Spagnesi MT, Tonelli F, Dolara P, et al. Rectal proliferation and polyp occurrence in patients with familial adenomatous polyposis after Sulindac treatment. Gastroenterology 106:362–366, 1994.

    PubMed  CAS  Google Scholar 

  • Steele GD. The National Cancer Data Base Report on colorectal cancer. Cancer 74:1979–1989, 1994.

    Article  PubMed  Google Scholar 

  • Steinbach G, Heymsfield S, Olansen NE, et al. Effect of caloric restriction on colonic proliferation in obese persons: implications for colon cancer prevention. Cancer Res 54:1194–1197, 1994.

    PubMed  CAS  Google Scholar 

  • Stopera SA, Bird RP. Effects of all-trans retinoic acid as a potential chemopreventive agent on the formation of azoxymethane-induced aberrant crypt foci. Int J Cancer 53:798–803, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Suh O, Mettlin C, Petrelli NJ. Aspirin use, cancer, and polyps of the large bowel. Cancer 72:1171–1177, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Swann PF, Code AM, Mace R. Ethanol and dimethylnitrosamine and diethylnitrosamine metabolism and disposition in the rat. Possible relevance to the influence of ethanol on human cancer incidence. Carcinogenesis 5:1337–1343, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Tanaka T, Kojima T, Kawamori T, et al. Chemoprevention of digestive organs carcinogenesis by natural product protocatechuic acid. Cancer 75 (Suppl 6): 1433–1439, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Tatsuta M, lishi H, Baba M, et al. Chemoprevention by amiloride of experimental carcinogenesis in rat colon induced by azoxymethane. Carcinogenesis 16:941–942, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Thun MJ, Namboodiri MM, Heath CW Jr. Aspirin use and reduced risk of fatal colon cancer. N Engl J Med 325:1593–1596, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Thun MJ, Namboodiri MM, Calle EE, et al. Aspirin use and risk of fatal cancer. Cancer Res 53:1322–1327, 1993.

    PubMed  CAS  Google Scholar 

  • Trujillo MA, Garewal HS, Stampliner RE. Non-steroidal anti-inflammatory agents in chemoprevention of colorectal cancer. At what cost? Dig Dis Sci 39:2260–2266, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Waddell WR, Loughry WR. Sulindac for polyposis of the colon. J Surg Oncol 24:83–87, 1983.

    Article  PubMed  CAS  Google Scholar 

  • Waddell WR, Gasner GF, Cerise EJ, et al. Sulindac for polyposis of the colon. Am J Surg 157:175–178, 1989.

    Article  PubMed  CAS  Google Scholar 

  • Wali RK, Bissonette M, Khare S, et al. 1 alpha, 25 dihydroxy-16-ene-23-yne, 27 hexafluorocholecalciferol, a noncalcemic analogue of 1 alpha, 25-dihydroxy vitamin D3, inhibits azoxymethane-induced colonie tumorigenesis. Cancer Res 55:3050–3054, 1995.

    PubMed  CAS  Google Scholar 

  • Wargovich MJ, Chen CD, Harris C, et al. Inhibition of aberrant crypt growth by non-steroidal anti-inflammatory agents and differentiation agents in the rat colon. Int J Cancer 60:515–519, 1995a.

    Article  PubMed  CAS  Google Scholar 

  • Wargovich MJ, Isbell MJ, Shabot M, et al. Calcium supplementation decreases rectal epithelial cell proliferation in subjects with sporadic adenoma. Gastroenterology 103:92–97, 1992.

    PubMed  CAS  Google Scholar 

  • Wargovich MJ, Jimenez A, Steele VE, et al. Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Gastroenterology 108.A551, 1995b.

    Google Scholar 

  • WHO European Collaborative Group. WHO European collaborative trial in the multifactorial prevention of coronary heart disease. In: M. Hakama, V. Beral, JWCullen, DM Parkin (eds), Evaluating Effectiveness of Primary Prevention of Cancer. Lyon: IARC Scientific Publication No. 103, 1990, pp 123–131.

    Google Scholar 

  • Wilhelmsen L, Berglund G, Elmfeldt D, et al. The multifactor primary prevention trial in Göteborg, Sweden. Eur Heart J 7:279–288, 1986.

    PubMed  CAS  Google Scholar 

  • Winawer SJ, Shike M. Dietary factors in colorectal cancer and their possible effects on earlier stages of hyperproliferation and adenoma formation. J Natl Cancer Inst 84:74–75, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Woodhill JM, Palmer AJ, Leelarthaepin B, et al. Low fat, low cholesterol diet in secondary prevention of coronary heart disease. Adv Exp Med Biol 109:317–330, 1978.

    PubMed  CAS  Google Scholar 

  • Yamamoto I, Maruyama H, Moriguchi M. Effect of beta-carotene, sodium ascorbate and cellulose on 1–2 dimethylhydrazine-induced intestinal carcinogenesis in rats. Cancer Lett 86:5–9, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Zelen M. Are primary cancer prevention trials feasible? J Natl Cancer Inst 80:12–15, 1988.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

Kune, G.A. (1996). Primary Prevention of Colorectal Tumors. In: Causes and Control of Colorectal Cancer. Developments in Oncology, vol 78. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1273-4_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1273-4_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8543-4

  • Online ISBN: 978-1-4613-1273-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics