Abstract
The essence of prevention of illness, including cancer, is the ability of individuals, groups, and of society in general to make changes in behavior.
It seems certain that cancer is to a very great extent preventable. Conquest of predisposition is possible. But the degree of justifiable hope will depend on the strength of the will.
The Honourable Rollo Russell Preventable Cancer. A Statistical Research. Longmans, Green, London 1912.
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References
Alabaster O, Tang Z, Frost A, et al. Effect of beta-carotene and wheat bran fiber on colonic aberrant crypt and tumor formation in rats exposed to azoxymethane and high dietary fat. Carcinogenesis 16:127–132, 1995.
Alabaster O, Tang ZC, Frost A, et al. Potential synergism between wheat bran and psyllium: enhanced inhibition of colon cancer. Cancer Lett 30:53–58, 1993.
Anti M, Armelao F, Marra G, et al. Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. Gastroenterology 107:1709–1718, 1994.
Armitage NC, Rooney PS, Gifford KA, at al. The effect of calcium supplements on rectal mucosal proliferation. Br J Cancer 71:186–190, 1995.
Baron JA, Tosteson TD, Wargovich MJ, et al. Calcium supplementation and rectal mucosal proliferation: a randomized controlled trial. J Natl Cancer Inst 87:1303–1307, 1995.
Barsoum GH, Hendrickse C, Winslet MC, et al. Reduction of mucosal crypt cell proliferation in patients with colorectal adenomatous polyps by dietary calcium supplementation. Br J Surg 79:581–583, 1992.
Beeson WL, Mills PK, Phillips RL, et al. Chronic disease among Seventh Day Adventists. A low risk group. Rationale, methodology and description of the population. Cancer 64:570–581, 1989.
Berkel J, de Waard F. Mortality pattern and life expectancy of Seventh Day Adventists in the Netherlands. Int J Epidemiol 12:455–459, 1983.
Bomalaski JS, Hirata F, Clark MA. Aspirin inhibits phospholipase C. Biochem Biophys Res Commun 139:115–121, 1986.
Bostick RM, Fosdick L, Wood JR, et al. Calcium and colorectal epithtlial cell proliferation in sporadic adenoma patients: a randomized double-blinded, placebo-controlled clinical trial. J Natl Cancer Inst 87:1307–1315, 1995.
Bussey JH, DeCosse JJ, Deschner EE, et al. A randomized trial of ascorbic acid in polyposis coli. Cancer 50:1434–1439, 1982.
Cahill RJ, O’Sullivan KR, Mathias PM, et al. Effects of vitamin antioxidant supplementation on cell kinetics of patients with adenomatous polyps. Gut 34:963–967, 1993.
Cats A, Kleibeuker JH, Van der Meer R, et al. Randomized double-blinded, placebo-controlled intervention study with supplemental calcium in families with hereditary non-polyposis colorectal cancer. J Natl Cancer Inst 87:598–603, 1995.
Cheng JY, Meng CL, Tzeng CC, et al. Optimal dose of garlic to inhibit dimethylhydrazine-induced colon cancer. World J Surg 19:621–625, 1995.
Chu KC, Tarone RE, Chow WH, et al. Temporal patterns in colorectal cancer incidence, survival and mortality from 1950 through 1990. J Natl Cancer Inst 86:997–1006, 1994.
Courtney JG, Longnecker MP, Theorell T, et al. Stressful life events and the risk of colorectal cancer. Epidemiology 4:407–414, 1993.
Craven PA, DeRubertis FR. Effects of aspirin on 1,2-dimethylhydrazine-induced colonic carcinogenesis. Carcinogenesis 13:541–546, 1992.
Cummings JH, Bingham SA, Heaton KW, et al. Fecal weight, colon cancer risk and dietary intake of non-starch polysaccharides (dietary fiber). Gastroenterology 103:1783–1789, 1992.
Dayton S, Pearce ML, Hashimoto S, et al. A controlled clinical trial of a diet high in unsaturated fat in preventing complications of atherosclerosis. Circulation 40 (Suppl II): 1–63, 1969.
DeCosse JJ, Miller HH, Lesser ML. Effect of wheat fiber and vitamins C and E on rectal polyps in patients with familial adenomatous polyposis. J Natl Cancer Inst 81:1290–1297, 1989.
Doll R, Peto R, Wheatley K, et al. Mortality in relation to smoking: 40 years’ observations on male British doctors. Br Med J 309:901–911, 1994.
Earnest D, Batta A, Holubec H, et al. Chemoprevention of colon cancer by ursodeoxycholic acid: a possible mechanism of action. Gastroenterology 108:A463, 1995.
Eberhart CE, Coffey RJ, Radhika A, et al. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107:1183–1188, 1994.
Ederer F, Leren P, Turpeinen O, et al. Cancer among men on cholesterol-lowering diets: experience from five clinical trials. Lancet ii:203–206, 1971.
Faivre J, Boutron MC, Doyon F, et al. The ECP calcium fibre polyp prevention study. Preliminary report. Eur J Cancer Prevention 2 (Suppl 2):99–106, 1993.
Frentzel-Beyme R, Chang-Claude J. Vegetarian diets and colon cancer: the German experience. Am J Clin Nutr 59 (Suppl 5):1143S–1152S, 1994.
Frentzel-Beyme R, Claude J, Eilber V. Mortality among German vegetarians: first results after five years of follow-up. Nutr Cancer 11:117–126, 1988.
Friedewald WT, Kuller LH, Ockene JK. Primary prevention of cancer: relevant multiple risk factor intervention trial results. In: Evaluating Effectiveness of Primary Prevention of Cancer. M. Hakama, V. Beral, JW Cullen, DM Parkin (eds) Lyon: IARC Scientific Publication 103, pp 157–170.
Furukawa K, Yamamoto I, Tanida N, et al. The effects of dietary fiber from Lagenaria scineraria (yugao-melon) on colonic carcinogenesis in mice. Cancer 75 (Suppl 6):1508–1515, 1995.
Gann PH, Manson JE, Glynn RJ, et al. Low-dose aspirin and incidence of colorectal tumors in a randomized trial. J Natl Cancer Inst 85:1220–1224, 1993.
Gapstur SM, Potter JD, Folsom AR. Alcohol consumption and colon and rectal cancer in postmenopausal women. Int J Epidemiol 23:50–57, 1994.
Giardiello FM, Hamilton SR, Krush AJ, et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med 328:1313–1316, 1993.
Giovannucci E, Egan KM, Hunter DJ, et al. Aspirin and the risk of colorectal cancer in women. N Engl J Med 333:609–614, 1995a.
Giovannucci E, Rimm EB, Acscherio A, et al. Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 87:265–273, 1995b.
Giovannucci E, Rimm EB, Stampfer MJ, et al. Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med 121:241–246, 1994.
Giovannucci E, Stampfer MJ, Colditz GA, et al. Folate, methionine and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 85:875–884, 1993.
Greenberg ER, Baron JA, Freeman DH Jr, et al. Reduced risk of large-bowel adenomas among aspirin users. J Natl Cancer Inst 85:912–916, 1993.
Greenberg ER, Baron JA, Tosteson TD, et al. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N Engl J Med 331:141–147, 1994.
Gridley G, McLaughlin JK, Ekbom A, et al. Incidence of cancer among patients with rheumatoid arthritis. J Natl Cancer Inst 85:307–311, 1993.
Hakulinen T, Pukkala E, Kenward M, et al. Changes in cancer incidence in North Karelia, an area with a comprehensive preventive cardiovascular programme. In: Evaluating Effectiveness of Primary Prevention of Cancer. M. Hakama, V. Beral, JW Cullen, DM Parkin (eds) Lyon: IARC Scientific Publication No. 103, pp 133–148.
Hjermann I, Velve-Byre K, Holme I, et al. Effect of diet and smoking intervention on the incidence of coronary heart disease: report from the Oslo Study Group of a randomised trial in healthy men. Lancet ii:1303–1310, 1981.
Huang MT, Lou YR, Ma W, et al. Inhibitory effects of dietary curcumin on forestomach, duodenal and colon carcinogenesis in mice. Cancer Res 54:5841–5847, 1994.
Ishikawa H, Akedo I, Suzuki T, et al. Interventional trial for colorectal cancer prevention in Osaka: an introduction to the protocol. Jpn J Cancer Res 86:707–710, 1995.
Jacobson JS, Neugut AI, Murray T, et al. Cigarette smoking and other behavioral risk factors for recurrence of colorectal adenomatous polyps (New York City, NY, USA). Cancer Causes Control 5:215–220, 1994.
Jensen OM. Cancer risk among Danish male Seventh-Day Adventists and other temperance society members. J Natl Cancer Inst 70:1010–1014, 1983.
Johanson JF, Salisbury D. Effectiveness of aspirin in preventing colorectal adenomas: Does dose matter? Gastroenterology 108:A486, 1995.
Kampman E, Giovannucci E, van’t Veer P, et al. Calcium, vitamin D, diary foods and the occurrence of colorectal adenomas among men and women in two prospective studies. Am J Epidemiol 139:16–29, 1994.
Kargman SL, O’Neill GP, Vickers PJ, et al. Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res 55:2556–2559, 1995.
Kawamori T, Tanaka T, Ohnishi M, et al. Chemoprevention of azoxymethane-induced colon carcinogenesis by dietary feeding of S-methyl methane thiosulfonate in male F344 rats. Cancer Res 55:4053–4058, 1995.
Kawamori T, Tanaka T, Suzui M, et al. Chemoprevention of azoxymethane-induced intestinal carcinogenesis by a novel synthesized retinoidal butenolide. Carcinogenesis 16:795–800, 1995b.
Kilias D, Macrae FA, Hughes N, et al. Rectal epithelial cell kinetics measured after four years of dietary intervention. A randomized controlled trial. J Gastroenterol Hepatol 8:A7, 1993.
Kleibeuker JH, Cats A, van der Meer R, et al. Calcium supplementation as prophylaxis against colon cancer? Dig Dis 12:85–97, 1994.
Koutsos MI, Schiff SJ, Qiao L, et al. Aspirin and other NSAIDs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. Gastroenterology 108:A492, 1995a.
Koutsos MI, Schiff SJ, Rigas B. The effect of ursodeoxycholic and lithocholic acid on cell cycle and apoptosis in human colon adenocarcinoma cells. Gastroenterology 108.A492, 1995b.
Kulkarni N, Reddy BS. Inhibitory effect of bifodobacterium longum cultures on the azoxymethane-induced aberrant crypt foci formation and fecal bacterial beta-glucuronidase. Proc Soc Exp Biol Med 207:278–283, 1994.
Kune GA. The psyche and the development of malignant disease. In: The Psyche and Cancer. GA Kune, S. Bannerman (eds) University of Melbourne 1992, pp 11–14, ISBN 0 7325 0502 X.
Kune GA, Bannerman S, Watson LF. Attributable risk for diet, alcohol, and family history in the Melbourne colorectal cancer study. Nutr Cancer 18:231–235, 1992.
Kune GA, Kune S. New design to examine colorectal cancer cause and survival. The Melbourne colorectal cancer study. Dig Surg 4:156–159, 1987.
Kune GA, Kune S. The Melbourne colorectal cancer study. A description of the investigation. University of Melbourne 1986, pp 1–31, ISBN 0 86839 596X.
Kune GA, Kune S, Watson LF. Colorectal cancer risk, chronic illnesses, operations and medications: case-control results from the Melbourne colorectal cancer study. Cancer Res 48:4399–4404, 1988.
Kune GA, Vitetta L. Alcohol consumption and the etiology of colorectal cancer: a review of the scientific evidence from 1957 to 1991. Nutr Cancer 18:97–111, 1992.
Kune GA, Vitetta L. The causes of colorectal adenomas: the key to the prevention of colorectal cancer? J Royal Soc Med 88:625–628, 1995.
Kune S. Stressful life events and cancer. Epidemiology 4:395–397, 1993.
Kune S, Kune GA, Watson LF. Case-control study of alcoholic beverages as etiological factors. The Melbourne colorectal cancer study. Nutr Cancer 9:43–56, 1987b.
Kune S, Kune GA, Watson LF. Case-control study of dietary etiological factors: the Melbourne colorectal cancer study. Nutr Cancer 9:21–42, 1987a.
Kune S, Kune GA, Watson LF, Rahe RH. Recent life change and large bowel cancer: data from the Melbourne colorectal cancer study. J Clin Epidemiol 44:57–68, 1991.
Labayle D, Fischer D, Vielh D, et al. Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology 101:635–639, 1991.
Ladenheim J, Garcia G, Titzer D, et al. Effect of Sulindac on sporadic colonic polyps. Gastroenterology 108:1083–1087, 1995.
Leren P. The Oslo Diet-Heart study: eleven-year report. Circulation 42:935–942, 1970.
Limburg PJ, Ahlquist DA, Talley NJ, et al. Decreased risk of colorectal cancer associated with peptic ulcer disease: a cohort study. Gastroenterology 106:A409, 1994.
Lipkin M. Biomarkers of increased susceptibility to gastrointestinal cancer: New application to studies of cancer prevention in human subjects. Cancer Res 48:235–245, 1988.
Lippmann SM, Lee JS, Lotan R, et al. Biomarkers as intermediate endpoints in chemoprevention trials. J Natl Cancer Inst 82:555–560, 1990.
Logan RFA, Little J, Hawtin PG, et al. Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme. Br Med J 307:285–289, 1993.
Logan RFA, Little J, Smith S, et al. Aspirin and non-steroidal anti-inflammatory drug (NSAID) use and symptomatic colorectal cancer: a case-control study. Gastroenterology 106:A546, 1994 and
Logan RFA, Little J, Smith S, et al. Aspirin and non-steroidal anti-inflammatory drug (NSAID) use and symptomatic colorectal cancer: a case-control study Gut 35:51, 1994.
Lubin F, Boeing H, Rozen P. Design and background of the Tel Aviv-Heidelberg dietary study of colonic adenoma patients and calcium intervention trial. Front Gastroenterol Res 18:74–87, 1991.
MacLennan R, Macrae FA, Bain C, et al. Effect of fat, fiber, and beta-carotene intake on colorectal adenomas: a randomized controlled dietary intervention trial after colonoscopic polypectomy. J Natl Cancer Inst (accepted for publication 1995).
MacLennan R, Ward M, Macrae F, et al. Effect of fat, fiber and beta-carotene intake on occurrence of colorectal adenomas after 24 months. Gastroenterology 100:A382, 1991.
Macrae F, MacLennan R, Ward M, et al. A randomised controlled trial of fat, fibre and beta-carotene on colorectal adenomas. Gastroenterology 108:A501, 1995
Macrae FA, Hughes NR, Bhathal PS, et al. Dietary suppression of rectal epithelial cell proliferation. Gastroenterology 100:A383, 1991.
Macrae FA, Kilias D, Sharpe K, et al. Rectal epithelial cell proliferation: comparison of errors of measurement with intersubject variance. J Cell Biochem 19:84–90, 1994a (Suppl).
Macrae FA, Russell A, MacLennan R, et al. Aspirin effects on large adenomas. Gastroenterology 106:A411, 1994b.
Marcus AJ. Aspirin as prophylaxis against colorectal cancer. N Engl J Med 333:656–658, 1995.
Mareto E, Frencia L, Ghia M. Effect of aspirin on incidence and growth of aberrant crypt foci induced in the rat colon by 1,2-dimethylhydrazine. Cancer Lett 76:5–9, 1994.
Marnett LJ. Aspirin and the potential role of prostaglandins in colon cancer. Perspectives in cancer research. Cancer Res 52:5575–5589, 1992.
Marnett LJ. Aspirin and related nonsteroidal anti-inflammatory drugs as chemopreventive agents against colon cancer. Preventive Med 24:103–106, 1995
McKeown-Eyssen G, Holloway C, Jazmaji V, et al. A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps. Cancer Res 48:4701–4705, 1988.
McKeown-Eyssen G, Bright-See E, Bruce WR. Recurrence of colorectal polyps: a randomized trial of low-fat, high-fiber diet. Am J Epidemiol 134:746, 1991.
McKeown-Eyssen G, Bright-See E, Bruce WR, et al. A randomized trial of low-fat high fiber diet in the recurrence of colorectal polyps. Toronto Polyp Prevention Group. J Clin Epidemiol 47:525–536, 1994.
McLaughlin JK, Hrubec Z, Blot WJ, et al. Smoking and cancer mortality among US veterans: a 26 year follow-up. Int J Cancer 60:190–193, 1995.
Mori H, Morishita Y, Shinoda T, et al. Preventive effect of magnesium hydroxide on carcinogen-induced large bowel carcinogenesis in rats. Basic Life Sci 61:111–118, 1993.
MRFIT Research Group. Multiple risk factor intervention trial: risk factor changes and mortality results. J Am Med Assoc 248:1465–1477, 1982.
Muscat JE, Stellman SD, Wynder EL. Nonsteroidal anti-inflammatory drugs and colorectal cancer. Cancer 74:1847–1854, 1994.
Muscat JE, Stellman SD, Wynder EL. Analgesic use and colorectal cancer. Preventive Med 24:110–112, 1995.
Müller AD, Sonnenberg A, Wasserman IH. NSAID-related reduction in the risk of colon cancer. Gastroenterology 106:A19, 1994.
Narisawa T, Fakaura Y. A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats. Jpn J Cancer Res 84:1007–1009, 1993.
Neugut AI, Garbowski GC, Lee WC, et al. Dietary risk factors for the incidence and recurrence of colorectal adenomatous polyps, a case-control study. Ann Intern Med 118:91–95, 1993.
Newcomb PA, Storer BE, Marcus PM. Cancer of the large bowel in women in relation to alcohol consumption: a case-control study in Wisconsin (United States). Cancer Causes Control 4:405–411, 1993.
Nordgaard L, Hove H, Clausen MR, et al. Increased colonic production of butyrate from dietary fiber (Plantago) in patients with former colonic cancer. Fourth United European Gastroenterology Week, Berlin, September 1995 (Abstract 2275).
Nugent KP, Farmer KC, Spigelman AD, et al. Randomized placebo controlled trial of the effect of Sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. Br J Surg 80:1618–1619, 1993.
Paganelli GM, Biasco G, Brandi G, et al. Effect of vitamin A, C and E supplementation on rectal cell proliferation in patients with colorectal adenomas. J Natl Cancer Inst 84:47–51, 1992.
Paganini-Hill A. Aspirin and colorectal cancer: the Leisure World cohort revisited. Preventive Med 24:113–115, 1995.
Paganini-Hill A, Chao A, Ross RK, et al. Aspirin use and chronic diseases: a cohort study of the elderly. Br Med J 229:1247–1250, 1989.
Paganini-Hill A, Hsu G, Ross RK, et al. Aspirin use and incidence of large-bowel cancer in a California retirement community. J Natl Cancer Inst 83:1182–1183, 1991.
Pearce ML, Dayton S. Incidence of cancer in men on a diet high in polyunsaturated fat. Lancet 1:464–467, 1971.
Peleg I, Maibach HT, Wilcox CM. Aspirin (ASA) NSAID use and the risk of subsequent colorectal polyps. Gastroenterology 104.A440, 1993.
Peleg I, Maibach HT, Brown SH, et al. Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer. Arch Intern Med 154:394–399, 1994.
Peleg I, Cotsonis GA, Clark WS, et al. The use of nonsteroidal, but not steroidal anti inflammatory drugs modulates the risk of colorectal adenoma and adenocarcinoma. Gastroenterology 108:A524, 1995.
Phillips RL. Role of lifestyle and dietary habits in risk of cancer among Seventh Day Adventists. Cancer Res 35:3513–3522, 1975.
Phillips RL, Kuzma JW, Lotz TM. Cancer mortality among comparable members versus non-members of the Seventh Day Adventist Church. In: Cairns J, Lyon JL, Skolnick M (eds). Banfield Report No. 4, Cancer Incidence in Defined Populations, Cold Spring Harbor Laboratory 1980, pp 93–107.
Phillips RL, Snowdon DA. Dietary relationships with fatal colorectal cancer among Seventh Day Adventists. J Natl Cancer Inst 74:307–317, 1985.
Potter JD. Hormones and colon cancer. J Natl Cancer Inst 87:1039–1040, 1995.
Powis G, Alberts DS. Inhibiting intracellular signalling as a strategy for cancer chemoprevention. Eur J Cancer 30A:1138–1144, 1994.
Rao AV, Goettler DM, Bird RP. The effects of a “low-risk” diet on tumor incidence in chemically induced colon cancer in rats. Nutr Cancer 11:11–20, 1988.
Rao CV, Desai D, Rivenson A, et al. Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate. Cancer Res 55:2310–2315, 1995b.
Rao CV, Rivenson A, Kelloff GJ, et al. Chemoprevention of azoxymethane-induced colon cancer by ascorbylpalmitate, carbenoxolone, dimethylfumarate and p-methoxyphenol In male F344rats. Anticancer Res 15:1199–1204, 1995.
Rao CV, Rivenson A, Simi B, et al. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res 55:259–266, 1995c.
Rao CV, Rivenson A, Simi B, et al. Chemoprevention of colon carcinogenesis by sulindac, a non-steroidal anti-inflammatory agent. Cancer Res 55:1464–1472, 1995a.
Rao CV, Simi B, Reddy BS. Inhibition by dietary curcumin of azoxymethane-induced ormithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis 14:2219–2225, 1993.
Reddy BS, Tokumo K, Kulharni N, et al. Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related compounds. Carcinogenesis 13:1019–1023, 1992.
Reddy BS, Rao CV, Rivenson A, et al. Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats. Carcinogenesis 14:1493–1497, 1993.
Reddy BS, Upadhyaya P, Simi B, et al. Evaluation of organoselenium compounds for potential chemopreventive properties in colon carcinogenesis. Anticancer Res 14:2509–2514, 1994.
Research Committee. Controlled trial of soya-bean oil in myocardial infarction: report of a research committee to the Medical Research Council. Lancet ii:693–700, 1968.
Roncucci L, Di Donato P, Carati L, et al. Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas. Dis Colon Rectum 36:227–234, 1993.
Rooney PS, Hunt LM, Clarke PA, et al. Wheat fibre, lactulose and rectal mucosal proliferation in individuals with a family history of colorectal cancer. Br J Surg 81:1792–1794, 1994.
Rose G. Comment on the Göteborg study by Wilhelmsen et al. Eur Heart J 7:288, 1986.
Rosenberg L, Palmer JR, Zauber AG, et al. A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer. J Natl Cancer Inst 83:355–358, 1991a.
Rosenberg L, Palmer JR, Shapiro S. Response. J Natl Cancer Inst 83:1183, 1991b.
Ruffin MT, Krishnan K, Kraus E. Aspirin as a chemopreventive agent for colorectal cancer: lowest dose of aspirin to suppress rectal mucosal prostaglandins. Proc Am Assoc Cancer Res 36:600, 1995 (Abstr).
Sano H, Kawahito Y, Wilder RL. Expression of cycloxygenase-1 and -2 in human colorectal cancer. Cancer Res 55:3785–3789, 1995.
Schatzkin A, Freedman LS, Schiffman MH, et al. Validation of intermediate endpoints in cancer research. J Natl Cancer Inst 82:1746–1752, 1990a.
Schatzkin A, Lanza E, Ballard-Barbash R. The case for a dietary intervention study of large bowel polyps. Cancer Prevention 1:84–90, 1990b.
Schatzkin A, Freedman LS, Dawsey SM, et al. Interpreting precursor studies: what polyp trials tell us about large-bowel cancer. J Natl Cancer Inst 86:1053–1057, 1994.
Schreinemachers DM, Everson RB. Aspirin use and lung, colon and breast cancer incidence in a prospective study. Epidemiology 5:138–146, 1994.
Sellers TA, Kushi LM, Potter JD. Can dietary intake patterns account for the familial aggregation of disease? Evidence from adult siblings living apart. Genetic Epidemiol 8:105–112, 1991.
Shike M, Winawer SJ, Greenwald PH, et al. Primary prevention of colorectal cancer. Bull WHO 68:377–385, 1990.
Shivapurkar N, Tang Z, Frost A, et al. Inhibition of progression of aberrant crypt foci and colon tumor development by vitamin E and beta-carotene on a high-risk diet. Cancer Lett 91:125–132, 1995.
Spagnesi MT, Tonelli F, Dolara P, et al. Rectal proliferation and polyp occurrence in patients with familial adenomatous polyposis after Sulindac treatment. Gastroenterology 106:362–366, 1994.
Steele GD. The National Cancer Data Base Report on colorectal cancer. Cancer 74:1979–1989, 1994.
Steinbach G, Heymsfield S, Olansen NE, et al. Effect of caloric restriction on colonic proliferation in obese persons: implications for colon cancer prevention. Cancer Res 54:1194–1197, 1994.
Stopera SA, Bird RP. Effects of all-trans retinoic acid as a potential chemopreventive agent on the formation of azoxymethane-induced aberrant crypt foci. Int J Cancer 53:798–803, 1993.
Suh O, Mettlin C, Petrelli NJ. Aspirin use, cancer, and polyps of the large bowel. Cancer 72:1171–1177, 1993.
Swann PF, Code AM, Mace R. Ethanol and dimethylnitrosamine and diethylnitrosamine metabolism and disposition in the rat. Possible relevance to the influence of ethanol on human cancer incidence. Carcinogenesis 5:1337–1343, 1984.
Tanaka T, Kojima T, Kawamori T, et al. Chemoprevention of digestive organs carcinogenesis by natural product protocatechuic acid. Cancer 75 (Suppl 6): 1433–1439, 1995.
Tatsuta M, lishi H, Baba M, et al. Chemoprevention by amiloride of experimental carcinogenesis in rat colon induced by azoxymethane. Carcinogenesis 16:941–942, 1995.
Thun MJ, Namboodiri MM, Heath CW Jr. Aspirin use and reduced risk of fatal colon cancer. N Engl J Med 325:1593–1596, 1991.
Thun MJ, Namboodiri MM, Calle EE, et al. Aspirin use and risk of fatal cancer. Cancer Res 53:1322–1327, 1993.
Trujillo MA, Garewal HS, Stampliner RE. Non-steroidal anti-inflammatory agents in chemoprevention of colorectal cancer. At what cost? Dig Dis Sci 39:2260–2266, 1994.
Waddell WR, Loughry WR. Sulindac for polyposis of the colon. J Surg Oncol 24:83–87, 1983.
Waddell WR, Gasner GF, Cerise EJ, et al. Sulindac for polyposis of the colon. Am J Surg 157:175–178, 1989.
Wali RK, Bissonette M, Khare S, et al. 1 alpha, 25 dihydroxy-16-ene-23-yne, 27 hexafluorocholecalciferol, a noncalcemic analogue of 1 alpha, 25-dihydroxy vitamin D3, inhibits azoxymethane-induced colonie tumorigenesis. Cancer Res 55:3050–3054, 1995.
Wargovich MJ, Chen CD, Harris C, et al. Inhibition of aberrant crypt growth by non-steroidal anti-inflammatory agents and differentiation agents in the rat colon. Int J Cancer 60:515–519, 1995a.
Wargovich MJ, Isbell MJ, Shabot M, et al. Calcium supplementation decreases rectal epithelial cell proliferation in subjects with sporadic adenoma. Gastroenterology 103:92–97, 1992.
Wargovich MJ, Jimenez A, Steele VE, et al. Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Gastroenterology 108.A551, 1995b.
WHO European Collaborative Group. WHO European collaborative trial in the multifactorial prevention of coronary heart disease. In: M. Hakama, V. Beral, JWCullen, DM Parkin (eds), Evaluating Effectiveness of Primary Prevention of Cancer. Lyon: IARC Scientific Publication No. 103, 1990, pp 123–131.
Wilhelmsen L, Berglund G, Elmfeldt D, et al. The multifactor primary prevention trial in Göteborg, Sweden. Eur Heart J 7:279–288, 1986.
Winawer SJ, Shike M. Dietary factors in colorectal cancer and their possible effects on earlier stages of hyperproliferation and adenoma formation. J Natl Cancer Inst 84:74–75, 1992.
Woodhill JM, Palmer AJ, Leelarthaepin B, et al. Low fat, low cholesterol diet in secondary prevention of coronary heart disease. Adv Exp Med Biol 109:317–330, 1978.
Yamamoto I, Maruyama H, Moriguchi M. Effect of beta-carotene, sodium ascorbate and cellulose on 1–2 dimethylhydrazine-induced intestinal carcinogenesis in rats. Cancer Lett 86:5–9, 1994.
Zelen M. Are primary cancer prevention trials feasible? J Natl Cancer Inst 80:12–15, 1988.
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Kune, G.A. (1996). Primary Prevention of Colorectal Tumors. In: Causes and Control of Colorectal Cancer. Developments in Oncology, vol 78. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1273-4_18
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