Bowel Habit — Constipation, Diarrhea and Laxative Use

  • Gabriel A. Kune
Part of the Developments in Oncology book series (DION, volume 78)

Abstract

It has been suggested that slow intestinal transit of feces through the large bowel is a risk for colorectal cancer. Slow intestinal transit may lead to constipation, however defined, so that constipation may be a marker for elevated colorectal cancer risk. At the other end of the bowel habit spectrum, it has been suggested that intestinal hurry, whatever the cause, and this may include laxative use, may have an irritant action on the mucosa of the large bowel, resulting in hyperplasia, dysplasia and neoplasia. It is known that in chronic ulcerative colitis and in chronic Crohn’s colitis, the risk of colorectal cancer is increased, but whether this is in part due to the associated chronic diarrhea, or mainly to other factors, is not known.

Keywords

Polysaccharide Diarrhea Lime Progesterone Paraffin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Boyd JT, Doll R. Gastro-intestinal cancer and the use of liquid paraffin. Br J Cancer 8:231–237, 1954.PubMedCrossRefGoogle Scholar
  2. Brown JP, Brown RJ. Mutagenesis by 9,10-anthraquinone derivatives and related compounds in Salmonella typhimurium. Mutation Res 40:203–224, 1976.PubMedCrossRefGoogle Scholar
  3. Burkitt DP. Epidemiology of cancer of the colon and rectum. Cancer 28:3–13, 1971.PubMedCrossRefGoogle Scholar
  4. Christofides ND, Ghatei MA, Bloom SR, et al. Decreased plasma motilin concentrations in pregnancy. Br Med J 285:1453–1454, 1982.CrossRefGoogle Scholar
  5. Connell AM, Hilton C, Irvine G, et al. Variation of bowel habit in two population samples. Br Med J 2:1095–1099, 1965.PubMedCrossRefGoogle Scholar
  6. Cummings JH, Bingham SA, Heaton KW, et al. Fecal weight, colon cancer risk and dietary intake of nonstarch polysaccharides (dietary fiber). Gastroenterology 103:1783–1789, 1992.PubMedGoogle Scholar
  7. Dales LG, Friedman GD, Ury HK, et al. A case-control study of relationships of diet and other traits to colorectal cancer in American blacks. Am J Epidemiol 109:132–144, 1979.PubMedGoogle Scholar
  8. Davies GJ, Crowder M, Reid B, et al. Bowel function measurements of individuals with different eating patterns. Gut 27:164–169, 1986.PubMedCrossRefGoogle Scholar
  9. Dent OF, Goulston KH, Zubryzcki J, et al. Bowel symptoms in an apparently well population. Dis Colon Rectum 29:243–247, 1986.PubMedCrossRefGoogle Scholar
  10. Drossman DA, Thompson WG, Talley NJ, et al. Identification of sub-groups of functional gastrointestinal disorders. Gastroenterol Int 3:159–172, 1990.Google Scholar
  11. Gapstur SM, Potter JD, Folsom AR. Alcohol consumption and colon and rectal cancer in post-menopausal women. Int J Epidemiol 23:50–57, 1994.PubMedCrossRefGoogle Scholar
  12. Gardiner JS, Walker SA, Macleari AJ. A retrospective mortality study of substituted anthraquinone on dye stuffs workers. Br J Indust Med 39:355–360, 1982.Google Scholar
  13. Heaton KW, Cripps HA. Straining at stool and laxative taking in an English population. Dig Dis Sci 38:1004–1008, 1993.PubMedCrossRefGoogle Scholar
  14. Heaton KW, O’Donnell LJD. An office guide to whole-gut transit-time: patients recollection of their stool form. J Clin Gastroenterol 19:28–30, 1994.PubMedCrossRefGoogle Scholar
  15. Inoue M, Tajima K, Hirose K, et al. Subsite-specific risk factors for colorectal cancer: a hospital-based case-control study in Japan. Cancer Causes Control 6:14–22, 1995.PubMedCrossRefGoogle Scholar
  16. Jain M, Cook GM, David FG, et al. A case control study of diet and colorectal cancer. Int J Cancer 26:757–768, 1980.PubMedCrossRefGoogle Scholar
  17. Kune GA. Laxative use not a risk for colorectal cancer: data from the Melbourne colorectal cancer study. Z. Gastroenterol 31:140–143, 1993.PubMedGoogle Scholar
  18. Kune GA, Kune S. A new design to examine colorectal cancer cause and survival. Dig Surg 4:156–159, 1987.CrossRefGoogle Scholar
  19. Kune GA, Kune S. The Melbourne colorectal cancer study: a description of the investigation. University of Melbourne, Department of Surgery publication ISBN 0 86839 596 X, pp 1–31, 1986.Google Scholar
  20. Kune GA, Kune S, Field B, et al. Survival in patients with large-bowel cancer. A population-based investigation from the Melbourne colorectal cancer study. Dis Colon Rectum 33:938–946, 1990.PubMedCrossRefGoogle Scholar
  21. Kune GA, Kune S, Field B, et al. The role of chronic constipation, diarrhea and laxative use in the etiology of large-bowel cancer. Data from the Melbourne colorectal cancer study. Dis Colon Rectum 31:507–512, 1988.PubMedCrossRefGoogle Scholar
  22. Kune S, Kune GA, Watson LF. Case-control study of dietary etiological factors: the Melbourne colorectal cancer study. Nutr Cancer 9:21–42, 1987.PubMedCrossRefGoogle Scholar
  23. Mori H, Sugie S, Niwa K, et al. Induction of intestinal tumours in rats by chrysazin. Br J Cancer 52:781–783, 1985.PubMedCrossRefGoogle Scholar
  24. O’Donnell LJD, Virjee J, Heaton KW. Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate. Br Med J 300:439–440, 1990.CrossRefGoogle Scholar
  25. Pernu J. An epidemiological study on cancer of the digestive organs and respiratory system: a study based on 7078 cases. Ann Intern Med Fenn 49 (suppl 33):1–117, 1960.Google Scholar
  26. Probert CSJ, Emmett PM, Cripps HA, et al. Evidence for the ambiguity of the term constipation: the role of irritable bowel syndrome. Gut 35:1455–1458, 1994.PubMedCrossRefGoogle Scholar
  27. Probert CJS, Emmett PM, Heaton KW. Intestinal transit time in the population calculated from self-made observations of defaecation. J Epid Comm Health 47:331–333, 1993.CrossRefGoogle Scholar
  28. Probert CJS, Emmett PM, Heaton KW. Some determinants of whole-gut transit time: a population-based study. Quart J Med 88:311–315, 1995.Google Scholar
  29. Siegers C-P, Scimers J, Baretton G. Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice. Pharmacology 47 (Suppl 1): 205–108, 1993b.CrossRefGoogle Scholar
  30. Siegers C-P, von Hertzberg-Lottin E, Otte M, et al. Anthranoid laxative abuse — a risk for colorectal cancer? Gut 34:1099–1101, 1993a.CrossRefGoogle Scholar
  31. Sonnenberg A, Muller AD. Constipation and cathartics as risk factors of colorectal cancer: A meta-analysis. Pharmacology 47 (Supple 1): 224–233, 1993.PubMedCrossRefGoogle Scholar
  32. Tikkanen L, Matsushima T, Natori S. Mutagenicity of anthraquinones in the Salmonella preincubation test. Mutation Res 116:297–304, 1983.PubMedCrossRefGoogle Scholar
  33. Vobecky J, Caro J, Devroede G. A case-control study of risk factors for large bowel carcinoma. Cancer 51:1958–1963, 1983.PubMedCrossRefGoogle Scholar
  34. Westendorf J, Marquardt H, Poginsky B, et al. Genotoxicity of naturally occurring hydroxyanthraquinones. Mutation Res 240:1–12, 1990.PubMedCrossRefGoogle Scholar
  35. Wu AG, Paganini-Hill A, Ross RK, et al. Alcohol, physical activity and other risk factors for colorectal cancer: a prospective study. Br J Cancer 55:687–694, 1987.PubMedCrossRefGoogle Scholar
  36. Wynder EL, Kajitani T, Ishikawa S, et al. Environmental factors of cancer of the colon and rectum. II Japanese epidemiological data. Cancer 23:1210–1220, 1969.PubMedCrossRefGoogle Scholar
  37. Wynder EL, Shigematsu T. Environmental factors of cancer of the colon and rectum. Cancer 20:1520–1560, 1967.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Gabriel A. Kune
    • 1
    • 2
  1. 1.University of MelbourneAustralia
  2. 2.Melbourne Colorectal Cancer StudyAustralia

Personalised recommendations