Therapeutic Interventions in the Diabetic Heart

  • John H. McNeill
  • Brian Rodrigues
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 185)


Chronic diabetics in general have a higher incidence of and mortality from cardiac disease [1,2]. A wide spectrum of cardiac problems plague the chronic diabetic and include left-ventricular dilatation and hypertrophy, lower stroke volume and cardiac output and abnormalities of left-ventricular ejection time and prolongation of the pre-ejection period [3–5]. Although studies have shown that the incidence of causative factors such as large and small vessel disease and autonomic neuropathy [6] are increased during diabetes, these factors cannot always be definitely implicated as contributing agents to myocardial problems, due to their absence in a significant number of diabetic patients [7]. These results suggest that a specific cardiomyopathy may be a causal factor in producing the increase in mortality and morbidity of diabetes [8,9].


Sarcoplasmic Reticulum Diabetic Cardiomyopathy Diabetic Heart Sodium Selenate Vanadyl Sulfate 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • John H. McNeill
  • Brian Rodrigues

There are no affiliations available

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