Differentiation of Human B-Cell Tumors: A Preclinical Model for Differentiation Therapy

  • Ayad M. Al-Katib
  • Ramzi Mohammad
Part of the Developments in Oncology book series (DION, volume 77)


B cell tumors in man include a group of heterogenous diseases with varying natural histories and responsiveness to therapy. Classic examples of B cell tumors are the chronic lymphocytic leukemia (CLL), Burkitt’s lymphoma and multiple myeloma. These tumors express the conventional B cell marker, that is, surface and/or cytoplasmic immunoglobulins. Malignant transformation, however, can affect precursors of the “mature” B lymphocytes as exemplified by the non-T cell acute lymphoblastic leukemia (ALL). Such cases demonstrate immunoglobulin gene rearrangements and react with monoclonal antibodies to B cell differentiation antigens. B cell tumors, therefore, represent a spectrum of disorders extending from the immature “stem cell” to the most mature “plasma cell” of the B lineage. It has been long hypothesized that disturbance in the differentiation pathway is important in the pathophysiology of malignancy (1). Phenotypic analysis of the B cell lineage has identified a malignant counterpart phenotype for each stage of the normal B cell differentiation pathway (3).


Chronic Lymphocytic Leukemia Phorbol Ester Chronic Lymphocytic Leukemia Cell Hairy Cell Severe Combine Immune Deficient Mouse 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Ayad M. Al-Katib
  • Ramzi Mohammad

There are no affiliations available

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