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Vanadium Compounds: Biochemical and Therapeutic Applications pp 39–47Cite as

Insulin-like actions of vanadate are mediated in an insulin-receptor-independent manner via non-receptor protein tyrosine kinases and protein phosphotyrosine phosphatases

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Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 16))

Abstract

Most or all mammalian cells contain vanadium at a concentration of 0.1–1.0 µM. The bulk of the vanadium in cells is probably in the reduced vanadyl (IV) form. Although this element is essential and should be present in the diet in minute quantities, no known physiological role for vanadium has been found thus far. In the years 1975—1980 the vanadate ion was shown to act as an efficient inhibitor of Na+,K+-ATPase and of other related phosphohydrolyzes as well. In 1980 it was observed that vanadate vanadyl, when added to intact rat adipocytes, mimics the biological actions of insulin in stimulating hexose uptake and glucose oxidation. This initiated a long, currently active, field of research among basic scientists and diabetologists. Several of the aspects studied are reviewed here.

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Author information

Authors and Affiliations

  1. Departments of Hormone Research, The Weizmann Institute of Science, Rehovot, 76100, Israel

    Yoram Shechter, Jingping Li, Gerard Elberg & Assia Shisheva

  2. Department of Pediatrics, Sheba Medical Center, Tel-Hashomer, Tel Aviv, Israel

    Joseph Meyerovitch

  3. Department of Internal Medicine B, Kaplan Hospital, Rehovot, Israel

    Dov Gefel

  4. Department of Gastroenterology, Wolfson Hospital, Holon, 58100, Israel

    Rafael Bruck

  5. National Institute of Health, NIEHS, Research Triangle Park, North Carolina, 27709, USA

    David S. Miller

Authors
  1. Yoram Shechter
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  2. Jingping Li
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  3. Joseph Meyerovitch
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  4. Dov Gefel
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  5. Rafael Bruck
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  6. Gerard Elberg
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  7. David S. Miller
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  8. Assia Shisheva
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Editors and Affiliations

  1. Centre de Recherche, Hotel-Dieu de Montreal, 3850, rue Saint Urbain, Pavillion Marie de la Ferre, Montreal, Quebec, H2W 1T8, Canada

    Ashok K. Srivastava  & Jean-Louis Chiasson  & 

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© 1995 Kluwer Academic Publishers

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Shechter, Y. et al. (1995). Insulin-like actions of vanadate are mediated in an insulin-receptor-independent manner via non-receptor protein tyrosine kinases and protein phosphotyrosine phosphatases. In: Srivastava, A.K., Chiasson, JL. (eds) Vanadium Compounds: Biochemical and Therapeutic Applications. Developments in Molecular and Cellular Biochemistry, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1251-2_5

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  • DOI: https://doi.org/10.1007/978-1-4613-1251-2_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8533-5

  • Online ISBN: 978-1-4613-1251-2

  • eBook Packages: Springer Book Archive

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