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The chemistry of peroxovanadium compounds relevant to insulin mimesis

  • Alan Shaver
  • Jesse B. Ng
  • David A. Hall
  • Barry I. Posner
Chapter
Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 16)

Abstract

The inorganic coordination chemistry of peroxovanadium compounds relevant to insulin mimesis is reviewed. The structure and kinetic reactivity of solutions of vanadate anion, vanadyl complexes and peroxovanadate complexes are briefly compared. Peroxovanadium compounds contain an oxo group, one or two peroxo ligands (O 2 2− ) and an ancillary ligand which is usually bidentate. These compounds approximate a trigonal bipyramidal structure which can be divided conceptually into a polar ‘oxo’ half and a relatively non-polar organic half. This presents a number of interesting design variations which are discussed with respect to the development of a rudimentary structure-activity correlation of insulin mimetic ability.

Key words

peroxovanadium compounds structure-activity relation of vanadium insulin mimetic activity 

Abbreviations

phen

1,10-phenanthroline

4,7-Me2phen

4,7-dimethyl-l,10-phenanthroline

3,4,7,8-Me4phen

3,4,7,8-tetramethyl-l,10-phenanthroline

5-CH3phen

5-methyl-1,10-phenanthroline

5-NO2phen

5-nitro-1,10-phenanthroline;

5-NH2phen

5-amino-1,10-phenanthroline

bipy

2,2′-bipyridine

bipyH

2,2′-bipyridinium

4,4′-Me2bipy

4,4′-dimethyl-2,2′-bipyridine

bipy-4,4′-(COO)2

2,2′-bipyridine-4,4′-dicarboxylato

pic

pyridine-2-carboxylato

3-OHpic

3-hydroxypyridine-2-carboxylato

3-acetpic

3-acetatoxypyridine-2-carboxylato

m,n-pdc

pyridine-m,n-dicarboxylato

ox

oxalato

pzc

pyrazine-2-carboxylato

3-NH2pzc

3-aminopyrazine-2-carboxylato

4OH-2,6pdc

4-hydroxy-2,6-pyridinedicarboxylato

IDA

iminodiacetato

cit

citrato

EDTA

ethylenediaminetetraacetato

HEDTA

ethylenediaminetetraacetic acid

isoquin

isoquinoline-2-carboxylato

quin

quinolato

NTA

nitrilotriacetato

glyH

glycine

cystH

cysteine

nicH

nicotinic acid

Hheida

N-(2-hydroxyethyl)iminodiacetato

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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Alan Shaver
    • 1
  • Jesse B. Ng
    • 1
  • David A. Hall
    • 1
  • Barry I. Posner
    • 1
  1. 1.Departments of Chemistry and MedicineMcGill UniversityMontréalCanada

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