Skip to main content

Cancer cell seeding during abdominal surgery: Experimental studies

  • Chapter

Part of the book series: Cancer Treatment and Research ((CTAR,volume 82))

Abstract

Surgical removal is for most abdominal cancers the only treatment that opens up the prospect of long-term survival. Surgery, however, appears to be a two-edged sword. In the wisdom of part of the general public in the Netherlands, it is commonly believed that patients will die sooner if their cancers are exposed to “air” during laparotomy. This belief, or perhaps shrewd observation, has been ridiculed by health professionals for a long time. However, many clinical observations appear to support the assumption that surgery can sometimes result in enhancement of tumor growth and spread.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Drouard F, Delamarre J, Capron JP. Cutaneous seeding of gallbladder cancer after laparoscopic cholecystectomy [letter]. N Engl J Med 1991;325:1316.

    PubMed  CAS  Google Scholar 

  2. Berends FJ, Kazemier G, Bonjer HJ, Lange JF. Subcutaneous metastases after laparoscopic colectomy [letter]. Lancet 1994;344:58.

    Article  PubMed  CAS  Google Scholar 

  3. Zwaveling A, Vroom EM. Topical use of cancerocidal agents in an experimental model. Arch Chir Need 1966;18:273–276.

    CAS  Google Scholar 

  4. Zoetmulder FAN. Model studies in colorectal cancer. Thesis, 1982, Rodopi, Amsterdam.

    Google Scholar 

  5. Zoetmulder FAN, Zwaveling A. Adjuvant chemotherapy in a new metastasizing caecum tumor model. Clin Exp Metast 1983;1:381–390.

    Article  CAS  Google Scholar 

  6. Moore GE. Assessment of the exfoliation of tumor cells into the body cavities. Surg Gynecol Obstet 1961;112:469–472.

    PubMed  CAS  Google Scholar 

  7. Kinoshita T, Ozaki H, Kosuge T, Shimada K. Effectiveness of intraoperative cytological examination of peritoneal washings for patients with pancreatic cancer (in Japanese). Nippon Geka Gakkai Zasshi. 1992;93:1410–1415.

    PubMed  CAS  Google Scholar 

  8. Zirngibl H, Husemann B, Hermanek P. Intraoperative spillage of tumor cells in surgery for recal cancer. Dis Colon Rectum 1990;33:610–614.

    Article  PubMed  CAS  Google Scholar 

  9. Sainz de la Cuesta R, Goff BA, Fuller AF Jr, Nikrui N, Eichorn JH, Rice LW. Prognostic importance of intraoperative rupture of malignant ovarian epithelial neoplasms. Obstet Gynecol 1994;84:1–7.

    PubMed  CAS  Google Scholar 

  10. Verbeek PC, Van der Heyde MN, Ramsoekh T, Bosma A. Clinical significance of implantation metastases after surgical treatment of cholangiocarcinoma. Semin Liver Dis 1990;10: 142–144.

    Article  PubMed  CAS  Google Scholar 

  11. Sweitzer KL, Nathanson SD, Nelson LT, Zachary C. Irrigation does not dislodge or destroy tumor cells adherent to the tumor bed. J Surg Oncol. 1993;53:184–190.

    Article  PubMed  CAS  Google Scholar 

  12. Francis JL, Cary N, Amirkhosravi M, Loizidou M, Cooper A, Taylor I. The effect of warfarin and factor VII on tissue procoagulant activity and pulmonary seeding. Br J Cancer 1992;65:329–334.

    Article  PubMed  CAS  Google Scholar 

  13. Goldstein DS, Lu ML, Hattori T, Ratliff TL, Loughlin KR, Kavoussi LR. Inhibition of peritoneal tumor-cell implantation: Model for laparoscopic cancer surgery. J Endourol 1993;7:237–242.

    Article  PubMed  CAS  Google Scholar 

  14. Frykholm GJ, Glimelius B, Pahlman L. Preoperative of postoperative irradiation in adenocarcinoma of the rectum: Final treatment results of a randomized trial and an evaluation of late secondary effect. Dis Colon Rectum 1993;36:564–572.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers, Boston

About this chapter

Cite this chapter

Zoetmulder, F.A.N. (1996). Cancer cell seeding during abdominal surgery: Experimental studies. In: Sugarbaker, P.H. (eds) Peritoneal Carcinomatosis: Principles of Management. Cancer Treatment and Research, vol 82. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1247-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1247-5_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8531-1

  • Online ISBN: 978-1-4613-1247-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics