Skip to main content

Mechanism and treatment of peritoneal carcinomatosis: intraperitoneal chemotherapy with mitomycin C bound to carbon particles

  • Chapter
Peritoneal Carcinomatosis: Drugs and Diseases

Part of the book series: Cancer Treatment and Research ((CTAR,volume 81))

  • 65 Accesses

Abstract

Peritoneal carcinomatosis is the most common type of recurrence after surgery for gastric cancer. However, the exact mechanism of recurrence has not been fully elucidated, and the treatment, therefore, has not been successful. We have been engaged in research [1–3] on peritoneal metastasis due to gastric cancer and have shown that cancer cells seeded in the peritoneal cavity are taken up by lymphatic tissues, such as omental milky spots and diaphragmatic stomata, to form peritoneal carcinomatosis, as described by Shimotsuma et al. in Chapter 9. These findings suggest that peritoneal metastases occur primarily at the site of the lymphatic tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Maki T, Majima S, Yoshida K, Takahashi T. Cancer cell dissemination during surgical manipulation. Tohoku J Exp Med 1963;79:319–333.

    Article  PubMed  CAS  Google Scholar 

  2. Kohno K, Yamaguchi T, Takahashi T. Experimental study on peritoneal dissemination of carcinoma, with special reference to the role of lymphatic system (in Japanese). Akita J Med, 1979;6:135–137.

    Google Scholar 

  3. Shimotsuma M, Sakuyama A, Shirasu, et al. The role of the lymphatic system of the greater omentum and diaphragm in intraperitoneal cancer dissemination (in Japanese with English summary). Jpn J Lymphol 1993;16:1–11.

    Google Scholar 

  4. Kaibara N, Hamazoe R, Iitsuka Y, et al. Hyperthermic peritoneal perfusion combined anticancer chemotherapy as prophylactic treatment of peritoneal recurrence of gastric cancer. Hepato-Gastro-enterology 1989;36:75–78.

    CAS  Google Scholar 

  5. Nakajima T, Hirashima S, Hirata M, et al. Prognostic and therapeutic values of peritoneal cytology in gastric cancer. Acta Cytolog 1978;22:225–229.

    CAS  Google Scholar 

  6. Takahashi, T. Emulsion and activated carbon in cancer chemotherapy. CRC Crit Rev Therap Drug Carrier Syst 1986;2:245–274.

    CAS  Google Scholar 

  7. Takahashi T, Sawai K, Hagiwara A, et al. Type-oriented therapy for gastric cancer effective for lymph node metastasis using activated carbon particles adsorbing an anticancer agent. Semin Surg Oncol 1991;7:378–383.

    Article  PubMed  CAS  Google Scholar 

  8. Hagiwara A, Takahashi T, Ueda T, et al. Intraoperative chemotherapy with carbon particles adsorbing mitomycin C for gastric cancer with peritoneal dissemination in rabbits. Surgery 1988;104:874–881.

    PubMed  CAS  Google Scholar 

  9. Hagiwara A, Takahashi T, Ueda T, et al. Toxicity and pathological effects of a new dosage form of mitomycin C for carcinomatous peritonitis. Anticancer Res 1987;7:105–108.

    PubMed  CAS  Google Scholar 

  10. Takahashi T, Hagiwara A, Sawai K, et al. Targeting chemotherapy to lymph node and peritoneal metastases of gastric cancer using high-dose mitomycin C absorbed on activated carbon particles. In Taguchi T, Aigner K, eds Mitomycin C in Cancer Chemotherapy Today. Amsterdam: Excerpta Medica, 1991, pp. 124–136.

    Google Scholar 

  11. Hagiwara A, Takahashi T, Kojima O, et al. Prophylaxis with carbon-adsorbed mitomycin against peritoneal recurrence of gastric cancer. Lancet 1992;339:629–631.

    Article  PubMed  CAS  Google Scholar 

  12. Hagiwara A, Takahashi T, Sawai K, et al. Milky spots as the implantation site for malignant cells in peritoneal dissemination in mice. Cancer Res 1993;53:678–692.

    Google Scholar 

  13. Shimotsuma M, Shields JS, Simpson-Morgen MW, et al. Morpho-physiological function and role of omental milky spots as omentum-associated lymphoid tissue (OALT) in the peritoneal cavity. Lymphology 1993;26:90–101.

    PubMed  CAS  Google Scholar 

  14. Takahashi T, Shimotsuma M, Hagiwara A, et al. Role of peritoneal lymphatics for peritoneal metastasis and chemotherapy with mitomycin C bound to carbon particles. Euro J Surg Oncol 1994;20:183–184.

    CAS  Google Scholar 

  15. Tobai S, Kawaguchi T, Asahina S, et al. Some findings on the intravasation of Yoshida sarcoma cells in the omentum. Gann 1980;71:578–579.

    PubMed  CAS  Google Scholar 

  16. Buck RC Walker 256 tumor implantation in normal and injured peritoneum studied by electron microscopy, scanning electron microscopy, and autoradiography. Cancer Res 1973;33:3181–3188.

    PubMed  CAS  Google Scholar 

  17. Koga S, Morphogenesis and prophylactic treatment of peritoneal metastasis in gastric cancer (in Japanese). Jpn J Gastroenterol Surg, 1984;17:1665–1674.

    Google Scholar 

  18. Hagiwara A, Takahashi T, Lee R, et al. Selective delivery of high levels of mitomycin C to peritoneal carcinomatosis using a new dosage form. Anticancer Res 1986;6:1161–1164.

    PubMed  CAS  Google Scholar 

  19. Hagiwara A, Takahashi T, Lee R, et al. Chemotherapy for carcinomatous peritonitis and pleuritis with MMC-CH, mitomycin C adsorbed on activated carbon particles. Cancer 1987;59:245–251.

    Article  PubMed  CAS  Google Scholar 

  20. Takahashi T, Hagiwara A, Sawai K, et al. Intensive intraoperative local chemotherapy for lymph node and peritoneal metastases in gastric cancer. Onkologie 1991;14:152–157.

    Article  Google Scholar 

  21. Sugarbaker PH, Zhu B-W, Sese GB, et al. Peritoneal carcinomatosis from appendiceal cancer—results in 69 patients treated by cytoreductive surgery and intraperitoneal chemotherapy. Dis Colon Rectum 1993;36:323–329.

    Article  PubMed  CAS  Google Scholar 

  22. Takahashi H, Mimata Y, Irinoda Y, et al. Studies on myocardial glucose metabolism of Adriamycin-administered rats using potassium-emitting radiopharmaceutical. Cyric Annual Report 1984;3:220–225.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers, Boston

About this chapter

Cite this chapter

Takahashi, T., Shimotsuma, M., Hagiwara, A., Yamaguchi, T. (1996). Mechanism and treatment of peritoneal carcinomatosis: intraperitoneal chemotherapy with mitomycin C bound to carbon particles. In: Sugarbaker, P.H. (eds) Peritoneal Carcinomatosis: Drugs and Diseases. Cancer Treatment and Research, vol 81. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1245-1_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1245-1_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-3726-3

  • Online ISBN: 978-1-4613-1245-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics