Abstract
Peritoneal carcinomatosis is the most common type of recurrence after surgery for gastric cancer. However, the exact mechanism of recurrence has not been fully elucidated, and the treatment, therefore, has not been successful. We have been engaged in research [1–3] on peritoneal metastasis due to gastric cancer and have shown that cancer cells seeded in the peritoneal cavity are taken up by lymphatic tissues, such as omental milky spots and diaphragmatic stomata, to form peritoneal carcinomatosis, as described by Shimotsuma et al. in Chapter 9. These findings suggest that peritoneal metastases occur primarily at the site of the lymphatic tissues.
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References
Maki T, Majima S, Yoshida K, Takahashi T. Cancer cell dissemination during surgical manipulation. Tohoku J Exp Med 1963;79:319–333.
Kohno K, Yamaguchi T, Takahashi T. Experimental study on peritoneal dissemination of carcinoma, with special reference to the role of lymphatic system (in Japanese). Akita J Med, 1979;6:135–137.
Shimotsuma M, Sakuyama A, Shirasu, et al. The role of the lymphatic system of the greater omentum and diaphragm in intraperitoneal cancer dissemination (in Japanese with English summary). Jpn J Lymphol 1993;16:1–11.
Kaibara N, Hamazoe R, Iitsuka Y, et al. Hyperthermic peritoneal perfusion combined anticancer chemotherapy as prophylactic treatment of peritoneal recurrence of gastric cancer. Hepato-Gastro-enterology 1989;36:75–78.
Nakajima T, Hirashima S, Hirata M, et al. Prognostic and therapeutic values of peritoneal cytology in gastric cancer. Acta Cytolog 1978;22:225–229.
Takahashi, T. Emulsion and activated carbon in cancer chemotherapy. CRC Crit Rev Therap Drug Carrier Syst 1986;2:245–274.
Takahashi T, Sawai K, Hagiwara A, et al. Type-oriented therapy for gastric cancer effective for lymph node metastasis using activated carbon particles adsorbing an anticancer agent. Semin Surg Oncol 1991;7:378–383.
Hagiwara A, Takahashi T, Ueda T, et al. Intraoperative chemotherapy with carbon particles adsorbing mitomycin C for gastric cancer with peritoneal dissemination in rabbits. Surgery 1988;104:874–881.
Hagiwara A, Takahashi T, Ueda T, et al. Toxicity and pathological effects of a new dosage form of mitomycin C for carcinomatous peritonitis. Anticancer Res 1987;7:105–108.
Takahashi T, Hagiwara A, Sawai K, et al. Targeting chemotherapy to lymph node and peritoneal metastases of gastric cancer using high-dose mitomycin C absorbed on activated carbon particles. In Taguchi T, Aigner K, eds Mitomycin C in Cancer Chemotherapy Today. Amsterdam: Excerpta Medica, 1991, pp. 124–136.
Hagiwara A, Takahashi T, Kojima O, et al. Prophylaxis with carbon-adsorbed mitomycin against peritoneal recurrence of gastric cancer. Lancet 1992;339:629–631.
Hagiwara A, Takahashi T, Sawai K, et al. Milky spots as the implantation site for malignant cells in peritoneal dissemination in mice. Cancer Res 1993;53:678–692.
Shimotsuma M, Shields JS, Simpson-Morgen MW, et al. Morpho-physiological function and role of omental milky spots as omentum-associated lymphoid tissue (OALT) in the peritoneal cavity. Lymphology 1993;26:90–101.
Takahashi T, Shimotsuma M, Hagiwara A, et al. Role of peritoneal lymphatics for peritoneal metastasis and chemotherapy with mitomycin C bound to carbon particles. Euro J Surg Oncol 1994;20:183–184.
Tobai S, Kawaguchi T, Asahina S, et al. Some findings on the intravasation of Yoshida sarcoma cells in the omentum. Gann 1980;71:578–579.
Buck RC Walker 256 tumor implantation in normal and injured peritoneum studied by electron microscopy, scanning electron microscopy, and autoradiography. Cancer Res 1973;33:3181–3188.
Koga S, Morphogenesis and prophylactic treatment of peritoneal metastasis in gastric cancer (in Japanese). Jpn J Gastroenterol Surg, 1984;17:1665–1674.
Hagiwara A, Takahashi T, Lee R, et al. Selective delivery of high levels of mitomycin C to peritoneal carcinomatosis using a new dosage form. Anticancer Res 1986;6:1161–1164.
Hagiwara A, Takahashi T, Lee R, et al. Chemotherapy for carcinomatous peritonitis and pleuritis with MMC-CH, mitomycin C adsorbed on activated carbon particles. Cancer 1987;59:245–251.
Takahashi T, Hagiwara A, Sawai K, et al. Intensive intraoperative local chemotherapy for lymph node and peritoneal metastases in gastric cancer. Onkologie 1991;14:152–157.
Sugarbaker PH, Zhu B-W, Sese GB, et al. Peritoneal carcinomatosis from appendiceal cancer—results in 69 patients treated by cytoreductive surgery and intraperitoneal chemotherapy. Dis Colon Rectum 1993;36:323–329.
Takahashi H, Mimata Y, Irinoda Y, et al. Studies on myocardial glucose metabolism of Adriamycin-administered rats using potassium-emitting radiopharmaceutical. Cyric Annual Report 1984;3:220–225.
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© 1996 Kluwer Academic Publishers, Boston
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Takahashi, T., Shimotsuma, M., Hagiwara, A., Yamaguchi, T. (1996). Mechanism and treatment of peritoneal carcinomatosis: intraperitoneal chemotherapy with mitomycin C bound to carbon particles. In: Sugarbaker, P.H. (eds) Peritoneal Carcinomatosis: Drugs and Diseases. Cancer Treatment and Research, vol 81. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1245-1_16
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DOI: https://doi.org/10.1007/978-1-4613-1245-1_16
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