Therapeutic Coronary Ultrasound Angioplasty in Patients with Symptomatic Coronary Artery Disease
Balloon angioplasty is the established treatment modality for patients with symptomatic single vessel and selected patients with multivessel coronary disease [1–3]. Technological advances in angioplasty equipment are responsible for the high initial success and low complication rates today. Accordingly, the list of indications for angioplasty was extended to patients with coronary disease previously not considered suitable for percutaneous interventions. However, balloons have limiting shortcomings under certain conditions, for example, in thrombotic, long, ostial, and calcified lesions. Another major drawback is the high rate of restenosis. In recent years new technologies have emerged that are currently not able to replace balloon angioplasty but that may have potential as adjunct devices. The therapeutic application of ultrasound energy has been under investigation for several years and has now reached the stage where it can be used in patients.
KeywordsAcute Myocardial Infarction Left Anterior Descend Right Coronary Artery Balloon Angioplasty Chronic Total Occlusion
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- 6.Siegel RJ, Gunn J, Ahsan A, Siegel RJ, Gunn J, Ashan A, Fishbein MC, Bowes RJ, Oakley D, Wales C, Steffen W, Campbell S, Nita H, Wills T, Silverton P, Myler RH, Cumberland DC. Use of therapeutic ultrasound in percutaneous coronary angioplasty: Experimental in vitro studies and initial clinical experience. Circulation 89:1587–1592, 1994.PubMedGoogle Scholar
- 7.Steffen W, Luo H, Nita H, Steffen W, Fishbein MC, Luo H, Lee DY, Nita H, Cumberland DC, Tabak SW, Carbonne M, Maurer G, Siegel RJ. High intensity, low frequency catheter delivered ultrasound dissolution of occlusive coronary artery thrombi: An in vitro and in vivo study. J Am Coll Cardiol 24:1571–1579, 1994.PubMedCrossRefGoogle Scholar
- 8.Rosenschein U, Bernstein JJ, Di Segni, Rosenschein U, Bernstein J, Di Segni E, Kaplinsky E, Bernheim J, Rozenszain LA. Experimental ultrasonic angioplasty: Disruption of atherosclerotic plaque and thrombi in vitro and arterial recanlization in vivo. J Am Coll Cardiol 15:711–717, 1990.PubMedCrossRefGoogle Scholar
- 9.Siegel RJ, Cumberland DC, Crew JR. Ultrasound recanalization of diseased arteries. From experimental studies to clinical application. Surg Clin North Am 74:879–897, 1992.Google Scholar
- 11.Siegel RJ, Nita H, Steffen W, Siegel RJ, Nita H, Steffen W, Fishbein MC, Passafaro J. Development of a flexible over-the-wire ultrasound coronary ablation catheter (abstr). Circulation 86(Suppl I):I457, 1992.Google Scholar