Interleukin-7 and lymphopoiesis: Biological and clinical implications

  • Pierette M. Appasamy
Part of the Cancer Treatment and Research book series (CTAR, volume 80)


IL-7 was identified in 1988 following an intensive search for bone-marrow stromal cell growth factors involved in early steps of B-cell genesis [1]. The role of IL-7 has since been expanded to include functions as a thymocyte growth factor and a pre-T-cell differentiation factor, as well as an activation factor for monocytes and macrophages, NK cells, cytolytic T lymphocytes (CTL’s), and lymphokine-activated killer cell (LAK) activity. Several preclinical studies in mice predict that IL-7 may be of use in antitumor therapy and acceleration of lymphoid recovery in lymphopenic patients. In addition, IL-7 appears to hold promise in enhancing antimicrobial responses. This chapter describes in detail the current status of IL-7 as a regulator of lymphopoiesis and effector cell function, and the potential therapeutic implications of the IL-7 preclinical studies performed in mice.


Acute Lymphoblastic Leukemia Gamma Delta Thymocyte Proliferation Stimulate Tyrosine Phosphorylation Fetal Thymocyte 
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© Kluwer Academic Publishers 1995

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  • Pierette M. Appasamy

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