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Interleukin-1 and its inhibitors: Implications for disease biology and therapy

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Cytokines: Interleukins and Their Receptors

Part of the book series: Cancer Treatment and Research ((CTAR,volume 80))

Abstract

Interleukin (IL)-1 is a polypeptide hormone that was described originally in the 1940s as an endogenous pyrogen, and later as a lymphocyte-activating factor. Two distinct IL-1 polypeptides termed IL-1α and IL-1β, have been identified and are known to be the products of distinct genes. IL-1α and IL-1β are members of a family of cytokines that also includes the IL-1 receptor antagonist protein (IL-1RA) [1,2]. Although found predominantly in monocytes, these cytokines are also produced by various normal and neoplastic cells [2–20]. IL-1α and IL-1β share 26-amino acid homology, they bind to the same receptor, and possess identical biological activities [21,22]. In contrast to the agonist activities of IL-1α and IL-1β, IL-1RA is a specific antagonist of IL-1 that acts by blocking the binding of IL-1 to its cell surface receptors [23–25].

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  1. Zeev Estrov
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  2. Razelle Kurzrock
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  3. Moshe Talpaz
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  1. Department of Bioimmunotherapy, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., Box 302, 77030, Houston, Texas, USA

    Razelle Kurzrock M.D.  & Moshe Talpaz M.D.  & 

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Estrov, Z., Kurzrock, R., Talpaz, M. (1995). Interleukin-1 and its inhibitors: Implications for disease biology and therapy. In: Kurzrock, R., Talpaz, M. (eds) Cytokines: Interleukins and Their Receptors. Cancer Treatment and Research, vol 80. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1241-3_3

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