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Depression of Sarcolemmal Phospholipase C Activity in Congestive Heart Failure

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Heart Hypertrophy and Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 169))

Abstract

The bioactivc phospholipids of the cardiac cell membrane (sarcolemma) and their signaling pathways are emerging as important mediators of the myocardial response to external stimuli, including catecholamines [1]. It is known that the activity of the sympathetic nervous system is increased in congestive heart failure; this results in elevated levels of plasma catecholamines, which downregulate the β-adrenoceptors in failing hearts, leading to subsensitivity of the β-agonist-mediated biochemical and mechanical responses [2]. The α1-adrenoceptors, which are associated with the positive inotropic effect of catecholamines via activation of the membranal phosphoinositide-phospholipase C (PLC) [1], were found to remain unchanged [3] or to increase [4,5] in heart failure. In view of the downregulation of the β-adrenoceptors, the α1 type reflects a greater proportion of the total adrenoceptor population in the failing ventricle [3–5]. Thus α1-adrenoceptors can be seen to play a dominant role in eliciting the positive inotropic action of catecholamines in failing heart [6].

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Authors
  1. Vincenzo Panagia
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  2. Johanna T. A. Meij
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  3. Nasrin Mesaeli
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  4. Rohit K. Singal
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  5. Naranjan S. Dhalla
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Editor information

Editors and Affiliations

  1. MRC Group in Experimental Cardiology Division of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, 351 Taché Avenue, Winnipeg, Manitoba, R2H 2A6, Canada

    Naranjan S. Dhalla (Distinguished Professor), Grant N. Pierce (Professor), Vincenzo Panagia (Professor) & Robert E. Beamish (Professor Emeritus) (Distinguished Professor),  (Professor),  (Professor) &  (Professor Emeritus)

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© 1995 Kluwer Academic Publishers

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Panagia, V., Meij, J.T.A., Mesaeli, N., Singal, R.K., Dhalla, N.S. (1995). Depression of Sarcolemmal Phospholipase C Activity in Congestive Heart Failure. In: Dhalla, N.S., Pierce, G.N., Panagia, V., Beamish, R.E. (eds) Heart Hypertrophy and Failure. Developments in Cardiovascular Medicine, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1237-6_17

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  • DOI: https://doi.org/10.1007/978-1-4613-1237-6_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8526-7

  • Online ISBN: 978-1-4613-1237-6

  • eBook Packages: Springer Book Archive

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