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Abnormalities in Cardiac Contractile Proteins and Cardiac Dysfunction

  • Chapter
Pathophysiology of Heart Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 168))

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Abstract

Multiple changes occur in the cardiac contractile protein assembly that contribute in concert to altered contractile performance in different pathologic states. It has been shown that cardiac myosin in some species exists in three isoenzymic forms and that these may vary depending on the animal’s age, species, and physiologic or pathologic state [1]. Isoenzymic changes in myosin can account for the changes in ATPase activity observed in a variety of models of cardiac hypertrophy [2]. A great deal of work in cardiac hypertrophy and failure has focused upon alterations in myosin ATPase activity and isoenzymes. Abnormalities in myofibrillar dose-response curves have been observed in experimental diabetic cardiomyopathy [3,4], pressure induced overload with and without congestive heart failure, ischemic cardiomyopathy, and idiopathic cardiomyopathy [5,6]. However, alterations in myosin have not been observed in humans. Thus, some component or components in the myofibrillar assembly other than myosin must be responsible for the decrement in cardiac funcition associated with heart disease in humans.

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Authors
  1. Ashwani Malhotra
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  2. Anthony J. Straceski
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  3. M. Cecilia Lopez
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  4. Antonio Nakouzi
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Editor information

Editors and Affiliations

  1. MRC Group in Experimental Cardiology Division of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla (Distinguished Professor), Pawan K. Singal (Professor) & Robert E. Beamish (Professor Emeritus) (Distinguished Professor),  (Professor) &  (Professor Emeritus)

  2. Department of Internal Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Nobuakira Takeda (Associate Professor) (Associate Professor)

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© 1996 Kluwer Academic Publishers

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Malhotra, A., Straceski, A.J., Lopez, M.C., Nakouzi, A. (1996). Abnormalities in Cardiac Contractile Proteins and Cardiac Dysfunction. In: Dhalla, N.S., Singal, P.K., Takeda, N., Beamish, R.E. (eds) Pathophysiology of Heart Failure. Developments in Cardiovascular Medicine, vol 168. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1235-2_7

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  • DOI: https://doi.org/10.1007/978-1-4613-1235-2_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8525-0

  • Online ISBN: 978-1-4613-1235-2

  • eBook Packages: Springer Book Archive

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